The central circadian clock proteins CCA1 and LHY regulate iron homeostasis in Arabidopsis

doi:10.1111/jipb.12696

IB-CAS > 中科院光生物学重点实验室

	The central circadian clock proteins CCA1 and LHY regulate iron homeostasis in Arabidopsis
	Xu, Gang 1,4; Jiang, Zhimin 1,5; Wang, Haiyang 2; Lin, Rongcheng1,3
	2019
发表期刊	JOURNAL OF INTEGRATIVE PLANT BIOLOGY
ISSN	1672-9072
卷号	61 期号:2 页码:168-181
摘要	Circadian clock is the endogenous time-keeping machinery that synchronizes an organism's metabolism, behavior, and physiology to the daily light-dark circles, thereby contributing to organismal fitness. Iron (Fe) is an essential micronutrient for all organisms and it plays important roles in diverse processes of plant growth and development. Here, we show that, in Arabidopsis thaliana, loss of the central clock genes, CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) and LATE ELONGATED HYPOCOTYL (LHY), results in both reduced Fe uptake and photosynthetic efficiency, whereas CCA1 overexpression confers the opposite effects. We show that root Fe(III) reduction activity, and expression of FERRIC REDUCTION OXIDASE 2 (FRO2) and IRON-REGULATED TRANSPORTER 1 (IRT1) exhibit circadian oscillations, which are disrupted in the cca1 lhy double mutant. Furthermore, CCA1 directly binds to the specific regulatory regions of multiple Fe homeostasis genes and activates their expression. Thus, this study established that, in plants, CCA1 and LHY function as master regulators that maintain cyclic Fe homeostasis.
学科领域	Biochemistry & Molecular Biology ; Plant Sciences
DOI	10.1111/jipb.12696
收录类别	SCI
语种	英语
WOS关键词	TRANSCRIPTION FACTOR ; OXIDATIVE STRESS ; PHOTOSYNTHESIS ; CHLOROPLAST ; EXPRESSION ; RESPONSES ; TIME ; IRT1 ; CLOCK-ASSOCIATED1 ; IDENTIFICATION
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences
WOS记录号	WOS:000459576800007
出版者	WILEY
文献子类	Article
出版地	HOBOKEN
EISSN	1744-7909
资助机构	Ministry of Agriculture of ChinaMinistry of Agriculture, China [2016ZX08009-003]
作者邮箱	rclin@ibcas.ac.cn
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/19631
专题	中科院光生物学重点实验室
作者单位	1.Chinese Acad Sci, Inst Bot, Key Lab Photobiol, Beijing 100093, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.South China Agr Univ, Coll Life Sci, Guangzhou 510642, Guangdong, Peoples R China 4.Chinese Acad Sci, Ctr Excellence Mol Plant Sci, Beijing 100093, Peoples R China 5.Shandong Agr Univ, Coll Life Sci, Tai An 271018, Shandong, Peoples R China 6.Chinese Acad Sci, Inst Genet & Dev Biol, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Xu, Gang,Jiang, Zhimin,Wang, Haiyang,et al. The central circadian clock proteins CCA1 and LHY regulate iron homeostasis in Arabidopsis[J]. JOURNAL OF INTEGRATIVE PLANT BIOLOGY,2019,61(2):168-181.
APA	Xu, Gang,Jiang, Zhimin,Wang, Haiyang,&Lin, Rongcheng.(2019).The central circadian clock proteins CCA1 and LHY regulate iron homeostasis in Arabidopsis.JOURNAL OF INTEGRATIVE PLANT BIOLOGY,61(2),168-181.
MLA	Xu, Gang,et al."The central circadian clock proteins CCA1 and LHY regulate iron homeostasis in Arabidopsis".JOURNAL OF INTEGRATIVE PLANT BIOLOGY 61.2(2019):168-181.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Integrative Plant Bi（3445KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览请求全文