IB-CAS  > 中科院植物分子生理学重点实验室
PRR5, 7and 9 positively modulate TOR signaling-mediated root cell proliferation by repressing TANDEM ZINC FINGER 1 in Arabidopsis
Li, Bin; Wang, Yan1; Zhang, Yuanyuan; Tian, Wenwen1; Chong, Kang; Jang, Jyan-Chyun; Wang, Lei1
2019
Source PublicationNUCLEIC ACIDS RESEARCH
ISSN0305-1048
Volume47Issue:10Pages:5001-5015
AbstractCircadian clock coordinates numerous plant growth and developmental processes including cell elongation in the hypocotyl, whether or not it modulates cell proliferation is largely unknown. Here we have found that Pseudo Response Regulators (PRRs), essential components of circadian core oscillators, affect root meristem cell proliferation mediated by Target Of Rapamycin (TOR) signaling. The null mutants of PRRs display much reduced sensitivities to sugar-activated TOR signaling. We have subsequently identified Tandem Zinc Finger 1, encoding a processing body localized RNA-binding protein, as a direct target repressed by PRRs in mediating TOR signaling. Multiple lines of biochemical and genetic evidence have demonstrated that TZF1 acts downstream of PRRs to attenuate TOR signaling. Furthermore, TZF1 could directly bind TOR mRNA via its tandem zinc finger motif to affect TOR mRNA stability. Our findings support a notion that PRR-TZF1-TOR molecular axis modulates root meristem cell proliferation by integrating both transcriptional and post-transcriptional regulatory mechanisms.
Subject AreaBiochemistry & Molecular Biology
DOI10.1093/nar/gkz191
Indexed BySCI
Language英语
WOS KeywordPSEUDO-RESPONSE REGULATORS ; CIRCADIAN CLOCK ; PLANT-GROWTH ; MUTANT REVEALS ; RNA-BINDING ; PROTEIN ; TARGET ; RAPAMYCIN ; PATHWAY ; STRESS
WOS Research AreaBiochemistry & Molecular Biology
WOS IDWOS:000471248400015
PublisherOXFORD UNIV PRESS
SubtypeArticle
Publication PlaceOXFORD
EISSN1362-4962
Funding OrganizationNational Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31570292] ; Strategic Priority Research Program of the Chinese Academy of SciencesChinese Academy of Sciences [XDB27030206] ; Chinese Academy of SciencesChinese Academy of Sciences [QYZDB-SSW-SMC011] ; Ohio Agricultural Research and Development Center SEEDS grant [2018-007] ; NSFCNational Natural Science Foundation of China (NSFC) [31570292]
Corresponding Author Emailwanglei@ibcas.ac.cn
OAGreen Published, gold, Green Submitted
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ibcas.ac.cn/handle/2S10CLM1/19701
Collection中科院植物分子生理学重点实验室
Affiliation1.Chinese Acad Sci, Key Lab Plant Mol Physiol, CAS Ctr Excellence Mol Plant Sci, Inst Bot, Beijing 10093, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Ohio State Univ, Dept Hort & Crop Sci, Columbus, OH 43210 USA
4.Ohio State Univ, Dept Mol Genet, Columbus, OH 43210 USA
Recommended Citation
GB/T 7714
Li, Bin,Wang, Yan,Zhang, Yuanyuan,et al. PRR5, 7and 9 positively modulate TOR signaling-mediated root cell proliferation by repressing TANDEM ZINC FINGER 1 in Arabidopsis[J]. NUCLEIC ACIDS RESEARCH,2019,47(10):5001-5015.
APA Li, Bin.,Wang, Yan.,Zhang, Yuanyuan.,Tian, Wenwen.,Chong, Kang.,...&Wang, Lei.(2019).PRR5, 7and 9 positively modulate TOR signaling-mediated root cell proliferation by repressing TANDEM ZINC FINGER 1 in Arabidopsis.NUCLEIC ACIDS RESEARCH,47(10),5001-5015.
MLA Li, Bin,et al."PRR5, 7and 9 positively modulate TOR signaling-mediated root cell proliferation by repressing TANDEM ZINC FINGER 1 in Arabidopsis".NUCLEIC ACIDS RESEARCH 47.10(2019):5001-5015.
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