PRR5, 7and 9 positively modulate TOR signaling-mediated root cell proliferation by repressing TANDEM ZINC FINGER 1 in Arabidopsis

doi:10.1093/nar/gkz191

	PRR5, 7and 9 positively modulate TOR signaling-mediated root cell proliferation by repressing TANDEM ZINC FINGER 1 in Arabidopsis
	Li, Bin ; Wang, Yan 1; Zhang, Yuanyuan ; Tian, Wenwen 1; Chong, Kang ; Jang, Jyan-Chyun ; Wang, Lei1
	2019
发表期刊	NUCLEIC ACIDS RESEARCH
ISSN	0305-1048
卷号	47 期号:10 页码:5001-5015
摘要	Circadian clock coordinates numerous plant growth and developmental processes including cell elongation in the hypocotyl, whether or not it modulates cell proliferation is largely unknown. Here we have found that Pseudo Response Regulators (PRRs), essential components of circadian core oscillators, affect root meristem cell proliferation mediated by Target Of Rapamycin (TOR) signaling. The null mutants of PRRs display much reduced sensitivities to sugar-activated TOR signaling. We have subsequently identified Tandem Zinc Finger 1, encoding a processing body localized RNA-binding protein, as a direct target repressed by PRRs in mediating TOR signaling. Multiple lines of biochemical and genetic evidence have demonstrated that TZF1 acts downstream of PRRs to attenuate TOR signaling. Furthermore, TZF1 could directly bind TOR mRNA via its tandem zinc finger motif to affect TOR mRNA stability. Our findings support a notion that PRR-TZF1-TOR molecular axis modulates root meristem cell proliferation by integrating both transcriptional and post-transcriptional regulatory mechanisms.
学科领域	Biochemistry & Molecular Biology
DOI	10.1093/nar/gkz191
收录类别	SCI
语种	英语
WOS关键词	PSEUDO-RESPONSE REGULATORS ; CIRCADIAN CLOCK ; PLANT-GROWTH ; MUTANT REVEALS ; RNA-BINDING ; PROTEIN ; TARGET ; RAPAMYCIN ; PATHWAY ; STRESS
WOS研究方向	Biochemistry & Molecular Biology
WOS记录号	WOS:000471248400015
出版者	OXFORD UNIV PRESS
文献子类	Article
出版地	OXFORD
EISSN	1362-4962
资助机构	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31570292] ; Strategic Priority Research Program of the Chinese Academy of SciencesChinese Academy of Sciences [XDB27030206] ; Chinese Academy of SciencesChinese Academy of Sciences [QYZDB-SSW-SMC011] ; Ohio Agricultural Research and Development Center SEEDS grant [2018-007] ; NSFCNational Natural Science Foundation of China (NSFC) [31570292]
作者邮箱	wanglei@ibcas.ac.cn
作品OA属性	Green Published, gold, Green Submitted
引用统计	被引频次：40[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/19701
专题	中科院植物分子生理学重点实验室
作者单位	1.Chinese Acad Sci, Key Lab Plant Mol Physiol, CAS Ctr Excellence Mol Plant Sci, Inst Bot, Beijing 10093, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Ohio State Univ, Dept Hort & Crop Sci, Columbus, OH 43210 USA 4.Ohio State Univ, Dept Mol Genet, Columbus, OH 43210 USA
推荐引用方式 GB/T 7714	Li, Bin,Wang, Yan,Zhang, Yuanyuan,et al. PRR5, 7and 9 positively modulate TOR signaling-mediated root cell proliferation by repressing TANDEM ZINC FINGER 1 in Arabidopsis[J]. NUCLEIC ACIDS RESEARCH,2019,47(10):5001-5015.
APA	Li, Bin.,Wang, Yan.,Zhang, Yuanyuan.,Tian, Wenwen.,Chong, Kang.,...&Wang, Lei.(2019).PRR5, 7and 9 positively modulate TOR signaling-mediated root cell proliferation by repressing TANDEM ZINC FINGER 1 in Arabidopsis.NUCLEIC ACIDS RESEARCH,47(10),5001-5015.
MLA	Li, Bin,et al."PRR5, 7and 9 positively modulate TOR signaling-mediated root cell proliferation by repressing TANDEM ZINC FINGER 1 in Arabidopsis".NUCLEIC ACIDS RESEARCH 47.10(2019):5001-5015.

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