Transposable elements drive rapid phenotypic variation in Capsella rubella

doi:10.1073/pnas.1811498116

	Transposable elements drive rapid phenotypic variation in Capsella rubella
	Niu, Xiao-Min ; Xu, Yong-Chao ; Li, Zi-Wen ; Bian, Yu-Tao ; Hou, Xing-Hui ; Chen, Jia-Fu ; Zou, Yu-Pan ; Jiang, Juan ; Wu, Qiong ; Ge, Song; Balasubramanian, Sureshkumar 2; Guo, Ya-Long
	2019
发表期刊	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN	0027-8424
卷号	116 期号:14 页码:6908-6913
摘要	Rapid phenotypic changes in traits of adaptive significance are crucial for organisms to thrive in changing environments. How such phenotypic variation is achieved rapidly, despite limited genetic variation in species that experience a genetic bottleneck is unknown. Capsella rubella, an annual and inbreeding forb (Brassicaceae), is a great system for studying this basic question. Its distribution is wider than those of its congeneric species, despite an extreme genetic bottleneck event that severely diminished its genetic variation. Here, we demonstrate that transposable elements (TEs) are an important source of genetic variation that could account for its high phenotypic diversity. TEs are (i) highly enriched in C. rubella compared with its outcrossing sister species Capsella grandiflora, and (ii) 4.2% of polymorphic TEs in C. rubella are associated with variation in the expression levels of their adjacent genes. Furthermore, we show that frequent TE insertions at FLOWERING LOCUS C (FLC) in natural populations of C. rubella could explain 12.5% of the natural variation in flowering time, a key life history trait correlated with fitness and adaptation. In particular, we show that a recent TE insertion at the 3' UTR of FLC affects mRNA stability, which results in reducing its steady-state expression levels, to promote the onset of flowering. Our results highlight that TE insertions can drive rapid phenotypic variation, which could potentially help with adaptation to changing environments in a species with limited standing genetic variation.
关键词	Brassicaceae Capsella rubella natural variation rapid phenotypic variation transposable elements
学科领域	Multidisciplinary Sciences
DOI	10.1073/pnas.1811498116
收录类别	SCI
语种	英语
WOS关键词	ARABIDOPSIS-THALIANA ; GENETIC PARADOX ; RECENT SPECIATION ; FLOWERING-TIME ; ADAPTATION ; EVOLUTION ; MUTATION ; IDENTIFICATION ; CONSEQUENCES ; EXPRESSION
WOS研究方向	Science & Technology - Other Topics
WOS记录号	WOS:000463069900067
出版者	NATL ACAD SCIENCES
文献子类	Article
出版地	WASHINGTON
资助机构	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [91731306] ; Strategic Priority Research Program of the Chinese Academy of SciencesChinese Academy of Sciences [XDB27010305] ; Innovative Academy of Seed Design, Chinese Academy of Sciences ; Chinese Academy of Sciences President's International Fellowship for Visiting Scientists ; Monash University Larkins Fellowship
作者邮箱	yalong.guo@ibcas.ac.cn
作品OA属性	Green Published, hybrid
引用统计	被引频次：75[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/19750
专题	系统与进化植物学国家重点实验室
作者单位	1.Chinese Acad Sci, Inst Bot, State Key Lab Systemat & Evolutionary Bot, Beijing 100093, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Monash Univ, Sch Biol Sci, Clayton, Vic 3800, Australia
推荐引用方式 GB/T 7714	Niu, Xiao-Min,Xu, Yong-Chao,Li, Zi-Wen,et al. Transposable elements drive rapid phenotypic variation in Capsella rubella[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2019,116(14):6908-6913.
APA	Niu, Xiao-Min.,Xu, Yong-Chao.,Li, Zi-Wen.,Bian, Yu-Tao.,Hou, Xing-Hui.,...&Guo, Ya-Long.(2019).Transposable elements drive rapid phenotypic variation in Capsella rubella.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,116(14),6908-6913.
MLA	Niu, Xiao-Min,et al."Transposable elements drive rapid phenotypic variation in Capsella rubella".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 116.14(2019):6908-6913.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Niu-2019-Transposabl（1322KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览请求全文