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Arabidopsis histone H3K4 demethylase JMJ17 functions in dehydration stress response
Huang, Shuangzhan; Zhang, Ai; Jin, Jing Bo1; Zhao, Bo2,3; Wang, Tian-Jing; Wu, Yifan; Wang, Shuang; Liu, Yutong; Wang, Jie; Guo, Peng; Ahmad, Rafiq; Liu, Bao; Xu, Zheng-Yi
Source PublicationNEW PHYTOLOGIST
AbstractUnder dehydration in plants, antagonistic activities of histone 3 lysine 4 (H3K4) methyltransferase and histone demethylase maintain a dynamic and homeostatic state of gene expression by orientating transcriptional reprogramming toward growth or stress tolerance. However, the histone demethylase that specifically controls histone methylation homeostasis under dehydration stress remains unknown. Here, we document that a histone demethylase, JMJ17, belonging to the KDM5/JARID1 family, plays crucial roles in response to dehydration stress and abscisic acid (ABA) in Arabidopsis thaliana. jmj17 loss-of-function mutants displayed dehydration stress tolerance and ABA hypersensitivity in terms of stomatal closure. JMJ17 specifically demethylated H3K4me1/2/3 via conserved iron-binding amino acids in vitro and in vivo. Moreover, H3K4 demethylase activity of JMJ17 was required for dehydration stress response. Systematic combination of genome-wide chromatin immunoprecipitation coupled with massively parallel DNA sequencing (ChIP-seq) and RNA-sequencing (RNA-seq) analyses revealed that a loss-of-function mutation in JMJ17 caused an ectopic increase in genome-wide H3K4me3 levels and activated a plethora of dehydration stress-responsive genes. Importantly, JMJ17 bound directly to the chromatin of OPEN STOMATA 1 (OST1) and demethylated H3K4me3 for the regulation of OST1 mRNA abundance, thereby modulating the dehydration stress response. Our results demonstrate a new function of a histone demethylase under dehydration stress in plants.
Keywordabiotic stress abscisic acid (ABA) Arabidopsis thaliana dehydration stress histone demethylation transcriptional regulation
Subject AreaPlant Sciences
Indexed BySCI
WOS Research AreaPlant Sciences
WOS IDWOS:000475918000029
Publication PlaceHOBOKEN
Funding OrganizationFundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [#2412018BJ002] Funding Source: Medline ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31601311, 31771352] Funding Source: Medline ; Natural Science Foundation of Jilin Province of China [20180101233JC] Funding Source: Medline ; National Key Research and Development Program of China [2016YFD0102003] Funding Source: Medline
Corresponding Author Emailbaoliu@nenu.edu.cn ; xuzy100@nenu.edu.cn
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Cited Times:32[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Northeast Normal Univ, Minist Educ MOE, Key Lab Mol Epigenet, Changchun 130024, Jilin, Peoples R China
2.Chinese Acad Sci, Inst Bot, Key Lab Mol Physiol, Beijing 100093, Peoples R China
3.Univ Texas Austin, Inst Cellular & Mol Biol, Austin, TX 78712 USA
4.Univ Texas Austin, Dept Mol Biosci, Austin, TX 78712 USA
Recommended Citation
GB/T 7714
Huang, Shuangzhan,Zhang, Ai,Jin, Jing Bo,et al. Arabidopsis histone H3K4 demethylase JMJ17 functions in dehydration stress response[J]. NEW PHYTOLOGIST,2019,223(3):1372-1387.
APA Huang, Shuangzhan.,Zhang, Ai.,Jin, Jing Bo.,Zhao, Bo.,Wang, Tian-Jing.,...&Xu, Zheng-Yi.(2019).Arabidopsis histone H3K4 demethylase JMJ17 functions in dehydration stress response.NEW PHYTOLOGIST,223(3),1372-1387.
MLA Huang, Shuangzhan,et al."Arabidopsis histone H3K4 demethylase JMJ17 functions in dehydration stress response".NEW PHYTOLOGIST 223.3(2019):1372-1387.
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