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| Arabidopsis O-GlcNAc transferase SEC activates histone methyltransferase ATX1 to regulate flowering | |
| Xing, Lijing; Liu, Yan1; Xu, Shujuan2; Xiao, Jun3; Wang, Bo2; Deng, Hanwen2; Lu, Zhuang; Xu, Yunyuan; Chong, Kang2,4 | |
| 2018 | |
| 发表期刊 | EMBO JOURNAL
 |
| ISSN | 0261-4189 |
| 卷号 | 37期号:19 |
| 摘要 | Post-translational modification of proteins by O-linked -N-acetylglucosamine (O-GlcNAc) is catalyzed by O-GlcNAc transferases (OGTs). O-GlcNAc modification of proteins regulates multiple important biological processes in metazoans. However, whether protein O-GlcNAcylation is involved in epigenetic processes during plant development is largely unknown. Here, we show that loss of function of SECRET AGENT (SEC), an OGT in Arabidopsis, leads to an early flowering phenotype. This results from reduced histone H3 lysine 4 trimethylation (H3K4me3) of FLOWERING LOCUS C (FLC) locus, which encodes a key negative regulator of flowering. SEC activates ARABIDOPSIS HOMOLOG OF TRITHORAX1 (ATX1), a histone lysine methyltransferase (HKMT), through O-GlcNAc modification to augment ATX1-mediated H3K4me3 histone modification at FLC locus. SEC transfers an O-GlcNAc group on Ser947 of ATX1,which resides in the SET domain, thereby activating ATX1. Taken together, these results uncover a novel post-translational O-GlcNAc modification-mediated mechanism for regulation of HKMT activity and establish the function of O-GlcNAc signaling in epigenetic processes in plants. |
| 关键词 | ATX1 HKMT activity O-GlcNAcylation SEC |
| 学科领域 | Biochemistry & Molecular Biology ; Cell Biology |
| DOI | 10.15252/embj.201798115 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS关键词 | BETA-N-ACETYLGLUCOSAMINE ; TRITHORAX GROUP PROTEINS ; POLYCOMB-GROUP PROTEINS ; GROWTH REPRESSOR DELLA ; LOCUS-C ; PLANT DEVELOPMENT ; H3K4 METHYLATION ; DOMAIN PROTEIN ; COMPLEX 2 ; GLCNACYLATION |
| WOS记录号 | WOS:000446029400003 |
| 出版者 | WILEY |
| 文献子类 | Article |
| 出版地 | HOBOKEN |
| EISSN | 1460-2075 |
| 资助机构 | Basic Science Center Project of National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31788103] ; National Key Research and Development Program of China [2016YFD0101004] |
| 作者邮箱 | chongk@ibcas.ac.cn |
| 作品OA属性 | Green Published, hybrid |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ibcas.ac.cn/handle/2S10CLM1/20393 |
| 专题 | 中科院植物分子生理学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Plant Mol Physiol, Inst Bot, Beijing, Peoples R China 2.Northeast Agr Univ, Coll Hort, Harbin, Heilongjiang, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Chinese Acad Sci, State Key Lab Plant Cell & Chromosome Engn, Inst Genet & Dev Biol, Beijing, Peoples R China 5.Natl Ctr Plant Gene Res, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xing, Lijing,Liu, Yan,Xu, Shujuan,et al. Arabidopsis O-GlcNAc transferase SEC activates histone methyltransferase ATX1 to regulate flowering[J]. EMBO JOURNAL,2018,37(19). |
| APA | Xing, Lijing.,Liu, Yan.,Xu, Shujuan.,Xiao, Jun.,Wang, Bo.,...&Chong, Kang.(2018).Arabidopsis O-GlcNAc transferase SEC activates histone methyltransferase ATX1 to regulate flowering.EMBO JOURNAL,37(19). |
| MLA | Xing, Lijing,et al."Arabidopsis O-GlcNAc transferase SEC activates histone methyltransferase ATX1 to regulate flowering".EMBO JOURNAL 37.19(2018). |
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| 30150325.pdf（1721KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
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