Anti-inflammatory constituents from Perilla frutescens on lipopolysaccharide-stimulated RAW264.7 cells

doi:10.1016/j.fitote.2018.08.006

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	Anti-inflammatory constituents from Perilla frutescens on lipopolysaccharide-stimulated RAW264.7 cells
	Wang, Xiao-Feng ; Li, Heng 1; Jiang, Kun ; Wang, Qi-Qi ; Zheng, Yan-Hai ; Tang, Wei 1; Tan, Chang-Heng
	2018
发表期刊	FITOTERAPIA
ISSN	0367-326X
卷号	130 页码:61-65
摘要	Perilla frutescens (L.) Britt. (Lamiaceae) is a traditionally medicinal herb in East Asian countries to treat various diseases. In present study, the low-polarity constituents of the aerial parts of P. frutescens were investigated and their anti-inflammatory effect on lipopolysaccharide (LPS)-stimulated RAW264.7 cells were assayed. Three new furanoid monoterpenoids, named as frutescenones A - C (1-3), together with thirteen known compounds (4-16) were isolated and identified on the basis of extensive spectroscopic analysis and a single-crystal X-ray diffraction study. Among these components, 1 is an unusual monoterpenoid with 2,3'-bifuran skeleton, and 3 is a rare perillaketone-adenine hybrid heterodimer, while the revised NMR arrangements of 4 were reported at the first time. Furthermore, monoterpenoid 4 and alkaloid 15 showed remarkably inhibitory effect on the production of inflammatory mediator (NO) and pro-inflammatory cytokines (TNF-alpha and/or IL-6) in LPS-stimulated RAW264.7 cells.
关键词	Perilla frutescens Lamiaceae Monoterpenoid Anti-inflammation RAW264.7 cell
学科领域	Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI	10.1016/j.fitote.2018.08.006
收录类别	SCI
语种	英语
WOS关键词	INHIBITION
WOS记录号	WOS:000449129500010
出版者	ELSEVIER
文献子类	Article
出版地	AMSTERDAM
EISSN	1873-6971
资助机构	Personalized Medicines - Molecular Signature -Based Drug Discovery and Development, Strategic Priority Research Program of Chinese Academy of Sciences, China [XDA12040315]
作者邮箱	tangwei@simm.ac.cn ; chtan@simm.ac.cn
引用统计	被引频次：33[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/20484
专题	其他人员
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Nat Med Chem, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Antiinflammat & Immunopharmacol, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Inst Bot, R&D Ctr Plant Factory, Beijing 100093, Peoples R China 4.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Xiao-Feng,Li, Heng,Jiang, Kun,et al. Anti-inflammatory constituents from Perilla frutescens on lipopolysaccharide-stimulated RAW264.7 cells[J]. FITOTERAPIA,2018,130:61-65.
APA	Wang, Xiao-Feng.,Li, Heng.,Jiang, Kun.,Wang, Qi-Qi.,Zheng, Yan-Hai.,...&Tan, Chang-Heng.(2018).Anti-inflammatory constituents from Perilla frutescens on lipopolysaccharide-stimulated RAW264.7 cells.FITOTERAPIA,130,61-65.
MLA	Wang, Xiao-Feng,et al."Anti-inflammatory constituents from Perilla frutescens on lipopolysaccharide-stimulated RAW264.7 cells".FITOTERAPIA 130(2018):61-65.

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