F-Type ATP Synthase Assembly Factors Atp11 and Atp12 in Arabidopsis

doi:10.3389/fpls.2020.522753

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	F-Type ATP Synthase Assembly Factors Atp11 and Atp12 in Arabidopsis
	Duan, Zhikun ; Li, Kaiwen ; Zhang, Lin 1; Che, Liping 1; Lu, Lizhen 2; Rochaix, Jean-David ; Lu, Congming 5; Peng, Lianwei 1
	2020
发表期刊	FRONTIERS IN PLANT SCIENCE
ISSN	1664-462X
卷号	11
摘要	Atp11p and Atp12p are members of two chaperone families essential for assembly of the mitochondrial ATP synthase in Saccharomyces cerevisiae and Homo sapiens. However, the role of their homologs in higher plants is unclear with regard to the assembly of both chloroplast ATP synthase (cpATPase) and mitochondrial ATP synthase (mtATPase). Here, we show that loss of either Atp11 or Atp12 is lethal in Arabidopsis. While Atp12 is only localized in mitochondria, Atp11 is present both in chloroplasts and mitochondria. Yeast two-hybrid analyses showed that, as their homologs in yeast, Atp11 specifically interacts with the beta subunit of the mtATPase and cpATPase, and Atp12 interacts with the alpha subunit of the mtATPase, implying that Atp11 and Atp12 fulfill a conserved task during assembly of ATP synthase. However, the binding sites for Atp11 in the beta subunit of mtATPase and cpATPase are slightly different, suggesting that the mechanisms of action may have evolved in different ways. Although Atp11 interacts with cpATPase beta subunit as the two assembly factors BFA3 and BFA1, they bind to different sites of the beta subunit. These results indicate that Atp11 is involved in the assembly of both cpATPase and mtATPase but Atp12 is specifically required for the assembly of mtATPase in higher plants.
关键词	ATP synthase assembly chloroplast mitochondria Atp11 Atp12
学科领域	Plant Sciences
DOI	10.3389/fpls.2020.522753
收录类别	SCI
语种	英语
WOS关键词	BIOGENESIS ; F-1-ATPASE ; CHAPERONES ; SUBUNIT
WOS研究方向	Plant Sciences
WOS记录号	WOS:000583972200001
出版者	FRONTIERS MEDIA SA
文献子类	Article
出版地	LAUSANNE
资助机构	China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2019M652522] ; Shanghai Engineering Research Center of Plant Germplasm Resources [17DZ2252700]
作者邮箱	penglianwei@shnu.edu.cn
作品OA属性	gold, Green Published
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/21536
专题	中科院光生物学重点实验室
作者单位	1.Henan Univ, Sch Life Sci, State Key Lab Crop Stress Adaptat & Improvement, Kaifeng, Peoples R China 2.Shanghai Normal Univ, Coll Life Sci, Shanghai Key Lab Plant Mol Sci, Shanghai, Peoples R China 3.Chinese Acad Sci, Inst Bot, Key Lab Photobiol, Beijing, Peoples R China 4.Univ Geneva, Dept Mol Biol, Geneva, Switzerland 5.Univ Geneva, Dept Plant Biol, Geneva, Switzerland 6.Shandong Agr Univ, Coll Life Sci, State Key Lab Crop Biol, Tai An, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Duan, Zhikun,Li, Kaiwen,Zhang, Lin,et al. F-Type ATP Synthase Assembly Factors Atp11 and Atp12 in Arabidopsis[J]. FRONTIERS IN PLANT SCIENCE,2020,11.
APA	Duan, Zhikun.,Li, Kaiwen.,Zhang, Lin.,Che, Liping.,Lu, Lizhen.,...&Peng, Lianwei.(2020).F-Type ATP Synthase Assembly Factors Atp11 and Atp12 in Arabidopsis.FRONTIERS IN PLANT SCIENCE,11.
MLA	Duan, Zhikun,et al."F-Type ATP Synthase Assembly Factors Atp11 and Atp12 in Arabidopsis".FRONTIERS IN PLANT SCIENCE 11(2020).

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