Hypotensive Activity of Transgenic Rice Seed Accumulating Multiple Antihypertensive Peptides

doi:10.1021/acs.jafc.0c01958

	Hypotensive Activity of Transgenic Rice Seed Accumulating Multiple Antihypertensive Peptides
	Qian, Dandan ; Qiu, Bin 1,2; Zhou, Nan ; Takaiwa, Fumio 3; Yong, Weidong 1,2; Qu, Le Qing
	2020
发表期刊	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN	0021-8561
卷号	68 期号:27 页码:7162-7168
摘要	Peptides derived from food protein have the potential to become antihypertensive agents with relatively few negative side effects. Herein, multiple antihypertensive peptides, extracted from the transgenic rice seed, were administered intragastrically into spontaneously hypertensive rats (SHRs) with different dosages, resulting in a significant decrease in the systolic blood pressure (SBP). Furthermore, for a period of 5 weeks, daily intragastric administration of the transgenic rice flour also significantly reduced the SBP of SHRs but not the Wistar Kyoto normotensive rats (WNRs), most importantly, which did not affect the growth, development, or serum chemistry of SHRs or WNRs and did not cause any pathological changes. Our work provides an alternative source of natural antihypertensive agents.
关键词	antihypertensive peptide transgenic rice hypertension food-derived bioactive peptide spontaneously hypertensive rats systolic blood pressure
学科领域	Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
DOI	10.1021/acs.jafc.0c01958
收录类别	SCI
语种	英语
WOS关键词	I-CONVERTING-ENZYME ; INHIBITORY PEPTIDES ; BLOOD-PRESSURE ; EXPRESSION ; PROTEIN ; DESIGN
WOS研究方向	Agriculture ; Chemistry ; Food Science & Technology
WOS记录号	WOS:000550642300010
出版者	AMER CHEMICAL SOC
文献子类	Article
出版地	WASHINGTON
EISSN	1520-5118
资助机构	National Program of Transgenic Variety Development of China [2016ZX08001-006]
作者邮箱	lqqu@ibcas.ac.cn
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/21669
专题	中科院植物分子生理学重点实验室
作者单位	1.Chinese Acad Sci, Innovat Acad Seed Design, Inst Bot, Key Lab Plant Mol Physiol, Beijing 100093, Peoples R China 2.Chinese Acad Med Sci, Inst Lab Anim Sci, Beijing 100021, Peoples R China 3.Peking Union Med Coll, Beijing 100021, Peoples R China 4.Natl Agr & Food Res Org, Div Biotechnol, Plant Mol Farming Unit, Inst Agrobiol Sci, Tsukuba, Ibaraki 3058602, Japan
推荐引用方式 GB/T 7714	Qian, Dandan,Qiu, Bin,Zhou, Nan,et al. Hypotensive Activity of Transgenic Rice Seed Accumulating Multiple Antihypertensive Peptides[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2020,68(27):7162-7168.
APA	Qian, Dandan,Qiu, Bin,Zhou, Nan,Takaiwa, Fumio,Yong, Weidong,&Qu, Le Qing.(2020).Hypotensive Activity of Transgenic Rice Seed Accumulating Multiple Antihypertensive Peptides.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,68(27),7162-7168.
MLA	Qian, Dandan,et al."Hypotensive Activity of Transgenic Rice Seed Accumulating Multiple Antihypertensive Peptides".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 68.27(2020):7162-7168.

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