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Microbial synthesized cadmium oxide nanoparticles induce oxidative stress and protein leakage in bacterial cells
Azam, Zara; Ayaz, Asma1; Younas, Muhammad; Qureshi, Zeeshan; Arshad, Bushra2; Zaman, Wajid3,4; Ullah, Fazal4,5; Nasar, Muhammad Qasim; Bahadur, Saraj6; Irfan, Mian Muhammad4,7; Hussain, Sajjad8; Saqib, Saddam3,4
2020
发表期刊MICROBIAL PATHOGENESIS
ISSN0882-4010
卷号144
摘要The bactericidal activity of metal oxide nanoparticles (NPs) offers extensive opportunities in bioengineering and biomedicines. Bioengineered transition metals used in various forms against lethal microbes. In this study, Cadmium Oxide nanoparticles (CdO-NPs) were prepared through the co-precipitation method using fungal strain Penicillium oxalicum and cadmium acetate solution. The structure and elemental composition of the prepared NPs were determined by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), UV-Vis absorption spectroscopy, scanning electron microscope (SEM) and energy dispersive spectroscopy (EDS). Antibacterial activity was assessed through well diffusion method against Staphylococcus aureus (S. aureus), Shigella dysenteriae (S. dysenteriae), and Pseudomonas aeruginosa (P. aeruginosa). In addition, reactive oxygen species (ROS), reducing sugars and protein leakage contribution was examined against selected strains. The XRD analysis proved that the synthesized CdO-NPs possess a crystalline structure with an average crystalline size of 40-80 nm. FTIR confirmed the presence of organic compounds on the particle surface, while UV showed stability of the particles. SEM and EDS confirmed that CdO-NPs were successfully prepared and spherical. The maximum zone of inhibition against S. dysenteriae and P. aeruginosa was found and showed a less optical density of 0.086 after 18 h. ROS, reducing sugar, and protein leakage assay showed a significant difference as compared to control. Based on the present study, it is recommended that microbial mediated synthesized nanoparticles can be used as biomedicines for the treatment of different types of bacterial infections.
关键词Microbial mediated Cadmium oxide nanoparticles Antibacterial activity Bioengineered Penicillium oxalicum
学科领域Immunology ; Microbiology
DOI10.1016/j.micpath.2020.104188
收录类别SCI
语种英语
WOS关键词ANTIBACTERIAL ACTIVITY ; SILVER NANOPARTICLES ; CDS NANOPARTICLES ; CYTOTOXICITY ; FUNGUS
WOS研究方向Immunology ; Microbiology
WOS记录号WOS:000537563900027
出版者ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
文献子类Article
出版地LONDON
作者邮箱asmaayaz@bs.qau.edu.pk ; younasktk@gmail.com ; bushrarshad1988@gmail.com ; shangla123@gmail.com ; fazalbotanist@gmail.com ; saddamsaqib.qau@gmail.com
引用统计
被引频次:50[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ibcas.ac.cn/handle/2S10CLM1/21737
专题植被与环境变化国家重点实验室
作者单位1.Mohi Ud Din Islamic Univ, Dept Biotechnol, Nerian Sharif, Aj&k, Pakistan
2.Hubei Univ, Sch Life Sci, State Key Lab Biocatalysis & Enzyme Engn, Wuhan 43400, Peoples R China
3.Minist Sci & Technol Islamabad, Pakistan Council Sci & Technol, Islamabad 45320, Pakistan
4.Chinese Acad Sci, Inst Bot, State Key Lab Systemat & Evolutionary Bot, Beijing 100093, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Chinese Acad Sci, Chengdu Inst Biol, CAS Key Lab Mt Ecol Restorat & Bioresource Utiliz, Chengdu 610041, Sichuan, Peoples R China
7.Hainan Univ Haikou, Coll Forestry, Haikou 50228, Hainan, Peoples R China
8.Chinese Acad Sci, Inst Bot, State Key Lab Vegetat & Environm Change Bot, Beijing 100093, Peoples R China
9.Henan Normal Univ, Sch Chem & Chem Engn, Henan Key Lab Boron Chem & Adv Energy Mat, Xinxiang, Henan, Peoples R China
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GB/T 7714
Azam, Zara,Ayaz, Asma,Younas, Muhammad,et al. Microbial synthesized cadmium oxide nanoparticles induce oxidative stress and protein leakage in bacterial cells[J]. MICROBIAL PATHOGENESIS,2020,144.
APA Azam, Zara.,Ayaz, Asma.,Younas, Muhammad.,Qureshi, Zeeshan.,Arshad, Bushra.,...&Saqib, Saddam.(2020).Microbial synthesized cadmium oxide nanoparticles induce oxidative stress and protein leakage in bacterial cells.MICROBIAL PATHOGENESIS,144.
MLA Azam, Zara,et al."Microbial synthesized cadmium oxide nanoparticles induce oxidative stress and protein leakage in bacterial cells".MICROBIAL PATHOGENESIS 144(2020).
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