IB-CAS  > 系统与进化植物学国家重点实验室
Disrupted-in-Schizophrenia-1 (DISC1) protein disturbs neural function in multiple disease-risk pathways
Shao, Lisha1; Lu, Binyan2; Wen, Zhexing3,4,5; Teng, Shaolei6; Wang, Lingling; Zhao, Yi; Wang, Liyuan; Ishizuka, Koko7; Xu, Xiufeng8; Sawa, Akira7; Song, Hongjun3,4,5; Ming, Guoli3,4,5; Zhong, Yi9
2017
Source PublicationHUMAN MOLECULAR GENETICS
ISSN0964-6906
Volume26Issue:14Pages:2634-2648
AbstractAlthough the genetic contribution is under debate, biological studies in multiple mouse models have suggested that the Disrupted-in-Schizophrenia-1 (DISC1) protein may contribute to susceptibility to psychiatric disorders. In the present study, we took the advantages of the Drosophila model to dissect the molecular pathways that can be affected by DISC1 in the context of pathology-related phenotypes. We found that three pathways that include the homologs of Drosophila Dys, Trio, and Shot were downregulated by introducing a C-terminal truncated mutant DISC1. Consistently, these three molecules were downregulated in the induced pluripotent stem cell-derived forebrain neurons from the subjects carrying a frameshift deletion in DISC1 C-terminus. Importantly, the three pathways were underscored in the pathophysiology of psychiatric disorders in bioinformatics analysis. Taken together, our findings are in line with the polygenic theory of psychiatric disorders.
Subject AreaPlant Sciences
DOI10.3897/phytokeys.86.20859
Indexed BySCI
Language英语
WOS KeywordDE-NOVO MUTATIONS ; PROGENITOR PROLIFERATION ; NEUROTRANSMITTER RELEASE ; DROSOPHILA-MELANOGASTER ; NEUROMUSCULAR-JUNCTION ; PSYCHIATRIC-DISORDERS ; MENTAL-ILLNESS ; SCHIZOPHRENIA ; GENE ; DYSTROPHIN
WOS IDWOS:000411804800002
PublisherOXFORD UNIV PRESS
SubtypeArticle
Publication PlaceOXFORD
EISSN1460-2083
Funding OrganizationNational Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [91332207, 91632301] ; National Basic Research Project (973 program) of Ministry of Science and Technology of China [2013cb835100] ; Beijing Municipal Science & Technology CommissionBeijing Municipal Science & Technology Commission [Z161100002616010] ; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [NS047344, NS048271, MH105128] ; MSCRF [MH-084018, MH-094268, MH-069853, MH-085226, MH-088753, MH-092443] ; Silvo O. Conte Center [DA-040127] ; NARSADNARSAD ; Stanley ; RUSK ; S-R Foundations ; NATIONAL INSTITUTE OF MENTAL HEALTHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Mental Health (NIMH) [R01MH069853, P20MH084018, R01MH105660, RC1MH088753, R21MH085226, P50MH094268, R01MH092443, R01MH105128] Funding Source: NIH RePORTER ; NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Neurological Disorders & Stroke (NINDS) [R56NS047344, R01NS047344, R37NS047344, R01NS048271] Funding Source: NIH RePORTER ; NATIONAL INSTITUTE ON DRUG ABUSEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Drug Abuse (NIDA)European Commission [R21DA040127] Funding Source: NIH RePORTER ; National Institute on Minority Health and Health DisparitiesUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Minority Health & Health Disparities (NIMHD) [G12MD007597] Funding Source: NIH RePORTER
Corresponding Author Emailzhongyi@cshl.edu
OAGreen Published, gold, Green Submitted
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ibcas.ac.cn/handle/2S10CLM1/22102
Collection系统与进化植物学国家重点实验室
Affiliation1.Tsinghua Univ, IDG McGovern Inst Brain Res, Sch Life Sci, Tsinghua Peking Ctr Life Sci,MOE Key Lab Prot Sci, Beijing 100084, Peoples R China
2.Howard Hughes Med Inst, Janelia Res Campus, Ashburn, VA 20147 USA
3.Chinese Acad Sci, Inst Bot, State Key Lab Systemat & Evolutionary Bot, Beijing 100093, Peoples R China
4.Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA
5.Emory Univ, Sch Med, Dept Cell Biol, Atlanta, GA 30322 USA
6.Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA
7.Howard Univ, Dept Biol, Washington, DC 20059 USA
8.Johns Hopkins Univ, Sch Med, Dept Psychiat, Mol Psychiat Program, Baltimore, MD 21287 USA
9.Kunming Med Univ, Affiliated Hosp 1, Dept Psychiat, Kunming 650032, Peoples R China
10.Cold Spring Harbor Lab, POB 100, Cold Spring Harbor, NY 11724 USA
Recommended Citation
GB/T 7714
Shao, Lisha,Lu, Binyan,Wen, Zhexing,et al. Disrupted-in-Schizophrenia-1 (DISC1) protein disturbs neural function in multiple disease-risk pathways[J]. HUMAN MOLECULAR GENETICS,2017,26(14):2634-2648.
APA Shao, Lisha.,Lu, Binyan.,Wen, Zhexing.,Teng, Shaolei.,Wang, Lingling.,...&Zhong, Yi.(2017).Disrupted-in-Schizophrenia-1 (DISC1) protein disturbs neural function in multiple disease-risk pathways.HUMAN MOLECULAR GENETICS,26(14),2634-2648.
MLA Shao, Lisha,et al."Disrupted-in-Schizophrenia-1 (DISC1) protein disturbs neural function in multiple disease-risk pathways".HUMAN MOLECULAR GENETICS 26.14(2017):2634-2648.
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