Knowledge Management System Of Institute Of Botany,CAS
| Three-Dimensional Evaluation on Ecotypic Diversity of Traditional Chinese Medicine: A Case Study of Artemisia annua L. | |
| Li, Lin1; Josef, Brinckmann A.; Liu, Bing3; Zheng, Sihao1; Huang, Linfang1; Chen, Shilin4 | |
| 2017 | |
| 发表期刊 | FRONTIERS IN PLANT SCIENCE
 |
| ISSN | 1664-462X |
| 卷号 | 8 |
| 摘要 | Artemisinin is the first-line drug for anti-malaria recommended by the World Health Organization (WHO). As the sole natural plant source of artemisinin, ecotypes of Artemisia annua L. vary widely in artemisinin content between nations, and China is the main producing area of A. annua. Here we present a three-dimensional evaluation on ecotypic diversity of A. annua from 12 main producing areas in China using highperformance liquid chromatography coupled with evaporative light scattering detection (HPLC-ELSD) method, DNA barcoding and ecological analyses. The results indicated that A. annua exhibited high ecotypic diversity. A. annua grown in the South of the Qinling Mountains-Huaihe River Line had a high artemisinin content, whereas the northern ones were low. Similar pattern was noted in the genetic diversity. The southern A. annua had high intraspecific variation in contrast to the northern A. annua. In terms of ecological analyses, humidity and sunshine time could be the major limiting ecological factors that affect the accumulation of artemisinin. This is the first reported threedimensional evaluation integrating chemical, molecular and ecological analyses of the ecotypic diversity of A. annua. The work will facilitate exploring the genetic basis of chemical variations and developing strategies for the breeding and cultivation of high quality A. annua. |
| 关键词 | Artemisia annua artemisinin DNA barcoding ecotype ecotypic diversity |
| 学科领域 | Biodiversity & Conservation ; Environmental Sciences & Ecology |
| DOI | 10.1016/j.biocon.2017.09.011 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS关键词 | PERFORMANCE LIQUID-CHROMATOGRAPHY ; DNA BARCODE ; GENETIC-CHARACTERIZATION ; ADAPTATION ; BIOMASS ; PROFILE ; GROWTH |
| WOS记录号 | WOS:000414883000018 |
| 出版者 | FRONTIERS MEDIA SA |
| 文献子类 | Article |
| 出版地 | LAUSANNE |
| 资助机构 | National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81473315] ; Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences [2016-12M-3-015] |
| 作者邮箱 | lfhuang@implad.ac.cn ; slchen@icmm.ac.cn |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ibcas.ac.cn/handle/2S10CLM1/22273 |
| 专题 | 系统与进化植物学国家重点实验室 |
| 作者单位 | 1.Chinese Acad Med Sci, Inst Med Plant Dev, Beijing, Peoples R China 2.Peking Union Med Coll, Beijing, Peoples R China 3.Josef, Brinckmann A.] Sustainabil Dept, Tradit Med, Sebastopol, CA USA 4.Chinese Acad Sci, Inst Bot, Beijing, Peoples R China 5.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Lin,Josef, Brinckmann A.,Liu, Bing,et al. Three-Dimensional Evaluation on Ecotypic Diversity of Traditional Chinese Medicine: A Case Study of Artemisia annua L.[J]. FRONTIERS IN PLANT SCIENCE,2017,8. |
| APA | Li, Lin,Josef, Brinckmann A.,Liu, Bing,Zheng, Sihao,Huang, Linfang,&Chen, Shilin.(2017).Three-Dimensional Evaluation on Ecotypic Diversity of Traditional Chinese Medicine: A Case Study of Artemisia annua L..FRONTIERS IN PLANT SCIENCE,8. |
| MLA | Li, Lin,et al."Three-Dimensional Evaluation on Ecotypic Diversity of Traditional Chinese Medicine: A Case Study of Artemisia annua L.".FRONTIERS IN PLANT SCIENCE 8(2017). |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| j.biocon.2017.09.011（2607KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
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