Long-term balancing selection contributes to adaptation in Arabidopsis and its relatives

doi:10.1093/botlinnean/box036

	Long-term balancing selection contributes to adaptation in Arabidopsis and its relatives
	Wu, Qiong ; Han, Ting-Shen ; Chen, Xi ; Chen, Jia-Fu ; Zou, Yu-Pan ; Li, Zi-Wen ; Xu, Yong-Chao ; Guo, Ya-Long
	2017
发表期刊	GENOME BIOLOGY
ISSN	1474-760X
卷号	18
摘要	Background: In contrast to positive selection, which reduces genetic variation by fixing beneficial alleles, balancing selection maintains genetic variation within a population or species and plays crucial roles in adaptation in diverse organisms. However, which genes, genome-wide, are under balancing selection and the extent to which these genes are involved in adaptation are largely unknown. Results: We performed a genome-wide scan for genes under balancing selection across two plant species, Arabidopsis thaliana and its relative Capsella rubella, which diverged about 8 million generations ago. Among hundreds of genes with shared coding-region polymorphisms, we find evidence for long-term balancing selection in five genes: AT1G35220, AT2G16570, AT4G29360, AT5G38460, and AT5G44000. These genes are involved in the response to biotic and abiotic stress and other fundamental biochemical processes. More intriguingly, for these genes, we detected significant ecological diversification between the two haplotype groups, suggesting that balancing selection has been very important for adaptation. Conclusions: Our results indicate that beyond the well-known S-locus genes and resistance genes, many loci are under balancing selection. These genes are mostly correlated with resistance to stress or other fundamental functions and likely play a more important role in adaptation to diverse habitats than previously thought.
关键词	Adaptation Arabidopsis thaliana Balancing selection Capsella rubella Trans-species polymorphism
学科领域	Plant Sciences
DOI	10.1093/botlinnean/box036
收录类别	SCI
语种	英语
WOS关键词	CAPSELLA-RUBELLA ; TRANSSPECIES POLYMORPHISM ; RECENT SPECIATION ; S-LOCUS ; GENOME ; THALIANA ; EVOLUTION ; RESISTANCE ; MAINTAINS ; HISTORY
WOS记录号	WOS:000406943300003
出版者	BMC
文献子类	Article
出版地	LONDON
资助机构	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [91231104, 31222006, 31470331, 61103066] ; 100 Talents Program of the Chinese Academy of SciencesChinese Academy of Sciences
作者邮箱	yalong.guo@ibcas.ac.cn
引用统计	被引频次：15[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/22285
专题	系统与进化植物学国家重点实验室
作者单位	1.[Wu, Qiong 2.Han, Ting-Shen 3.Chen, Xi 4.Chen, Jia-Fu 5.Zou, Yu-Pan 6.Li, Zi-Wen 7.Xu, Yong-Chao 8.Chinese Acad Sci, Inst Bot, State Key Lab Systemat & Evolutionary Bot, Beijing 100093, Peoples R China 9.[Han, Ting-Shen 10.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wu, Qiong,Han, Ting-Shen,Chen, Xi,et al. Long-term balancing selection contributes to adaptation in Arabidopsis and its relatives[J]. GENOME BIOLOGY,2017,18.
APA	Wu, Qiong.,Han, Ting-Shen.,Chen, Xi.,Chen, Jia-Fu.,Zou, Yu-Pan.,...&Guo, Ya-Long.(2017).Long-term balancing selection contributes to adaptation in Arabidopsis and its relatives.GENOME BIOLOGY,18.
MLA	Wu, Qiong,et al."Long-term balancing selection contributes to adaptation in Arabidopsis and its relatives".GENOME BIOLOGY 18(2017).

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