GIGANTEA is a co-chaperone which facilitates maturation of ZEITLUPE in the Arabidopsis circadian clock

doi:10.1038/s41598-017-04524-9

	GIGANTEA is a co-chaperone which facilitates maturation of ZEITLUPE in the Arabidopsis circadian clock
	Cha, Joon-Yung ; Kim, Jeongsik 2; Kim, Tae-Sung ; Zeng, Qingning ; Wang, Lei4 ; Lee, Sang Yeol ; Kim, Woe-Yeon ; Somers, David E.
	2017
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
卷号	8
摘要	Circadian clock systems help establish the correct daily phasing of the behavioral, developmental, and molecular events needed for the proper coordination of physiology and metabolism. The circadian oscillator comprises transcription-translation feedback loops but also requires post-translational processes that regulate clock protein homeostasis. GIGANTEA is a unique plant protein involved in the maintenance and control of numerous facets of plant physiology and development. Through an unknown mechanism GIGANTEA stabilizes the F-box protein ZEITLUPE, a key regulator of the circadian clock. Here, we show that GIGANTEA has general protein chaperone activity and can act to specifically facilitate ZEITLUPE maturation into an active form in vitro and in planta. GIGANTEA forms a ternary complex with HSP90 and ZEITLUPE and its co-chaperone action synergistically enhances HSP90/HSP70 maturation of ZEITLUPE in vitro. These results identify a molecular mechanism for GIGANTEA activity that can explain its wide-ranging role in plant biology.
学科领域	Science & Technology - Other Topics
DOI	10.1038/s41598-017-04524-9
收录类别	SCI
语种	英语
WOS关键词	BOX PROTEIN ZEITLUPE ; IN-VITRO ; POSTTRANSLATIONAL REGULATION ; FUNCTIONAL-CHARACTERIZATION ; TARGETED DEGRADATION ; REGULATOR PROTEINS ; SCFZTL COMPLEX ; BLUE-LIGHT ; HSP90 ; THALIANA
WOS记录号	WOS:000403874900076
出版者	NATURE PUBLISHING GROUP
文献子类	Article
出版地	LONDON
资助机构	National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01GM093285] ; Next-Generation BioGreen21 Program (SSAC)Rural Development Administration (RDA) [PJ01106901] ; Rural Development Administration, Republic of KoreaRural Development Administration (RDA) ; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of General Medical Sciences (NIGMS) [R01GM093285] Funding Source: NIH RePORTER
作者邮箱	kim1312@gnu.ac.kr ; somers.24@osu.edu
作品OA属性	gold, Green Published
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/22368
专题	中科院植物分子生理学重点实验室
作者单位	1.Gyeongsang Natl Univ, PMBBRC & IALS, Div Appl Life Sci, BK21Plus, Jinju 52828, South Korea 2.Kim, Jeongsik; Kim, Tae-Sung; Zeng, Qingning; Wang, Lei; Somers, David E.] Ohio State Univ, Dept Mol Genet, Columbus, OH 43210 USA 3.Inst Basic Sci, Ctr Plant Aging Res, Daegu 711873, South Korea 4.Korea Natl Open Univ, Dept Agr Sci, Seoul 03087, South Korea 5.Chinese Acad Sci, Inst Bot, Key Lab Plant Mol Physiol, Beijing 100093, Peoples R China
推荐引用方式 GB/T 7714	Cha, Joon-Yung,Kim, Jeongsik,Kim, Tae-Sung,et al. GIGANTEA is a co-chaperone which facilitates maturation of ZEITLUPE in the Arabidopsis circadian clock[J]. NATURE COMMUNICATIONS,2017,8.
APA	Cha, Joon-Yung.,Kim, Jeongsik.,Kim, Tae-Sung.,Zeng, Qingning.,Wang, Lei.,...&Somers, David E..(2017).GIGANTEA is a co-chaperone which facilitates maturation of ZEITLUPE in the Arabidopsis circadian clock.NATURE COMMUNICATIONS,8.
MLA	Cha, Joon-Yung,et al."GIGANTEA is a co-chaperone which facilitates maturation of ZEITLUPE in the Arabidopsis circadian clock".NATURE COMMUNICATIONS 8(2017).

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Liu-2017-Genome-wide（5296KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览请求全文