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| Convergence and divergence of bitterness biosynthesis and regulation in Cucurbitaceae | |
| Zhou, Yuan1,2; Ma, Yongshuo; Zeng, Jianguo2; Duan, Lixin3; Xue, Xiaofeng4; Wang, Huaisong; Lin, Tao1; Liu, Zhiqiang5; Zeng, Kewu6; Zhong, Yang; Zhang, Shu; Hu, Qun7; Liu, Min; Zhang, Huimin; Reed, James8; Moses, Tessa8; Liu, Xinyan; Huang, Peng2; Qing, Zhixing9; Liu, Xiubin2; Tu, Pengfei6; Kuang, Hanhui7; Zhang, Zhonghua; Osbourn, Anne8; Ro, Dae-Kyun; Shang, Yi1; Huang, Sanwen1 | |
| 2016 | |
| 发表期刊 | NATURE PLANTS
 |
| ISSN | 2055-026X |
| 卷号 | 2期号:12 |
| 摘要 | Differentiation of secondary metabolite profiles in closely related plant species provides clues for unravelling biosynthetic pathways and regulatory circuits, an area that is still underinvestigated. Cucurbitacins, a group of bitter and highly oxygenated tetracyclic triterpenes, are mainly produced by the plant family Cucurbitaceae. These compounds have similar structures, but differ in their antitumour activities and ecophysiological roles. By comparative analyses of the genomes of cucumber, melon and watermelon, we uncovered conserved syntenic loci encoding metabolic genes for distinct cucurbitacins. Characterization of the cytochrome P450s (CYPs) identified from these loci enabled us to unveil a novel multi-oxidation CYP for the tailoring of the cucurbitacin core skeleton as well as two other CYPs responsible for the key structural variations among cucurbitacins C, B and E. We also discovered a syntenic gene cluster of transcription factors that regulates the tissue-specific biosynthesis of cucurbitacins and may confer the loss of bitterness phenotypes associated with convergent domestication of wild cucurbits. This study illustrates the potential to exploit comparative genomics to identify enzymes and transcription factors that control the biosynthesis of structurally related yet unique natural products. |
| 学科领域 | Plant Sciences |
| DOI | 10.1038/NPLANTS.2016.183 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS关键词 | CUCUMIS-SATIVUS L ; BIOLOGICAL-ACTIVITIES ; PANCREATIC-CANCER ; GENE CLUSTERS ; GENOME ; PLANTS ; DOMESTICATION ; GEMCITABINE ; METABOLISM ; WATERMELON |
| WOS研究方向 | Science Citation Index Expanded (SCI-EXPANDED) |
| WOS记录号 | WOS:000395793200006 |
| 出版者 | NATURE PUBLISHING GROUP |
| 文献子类 | Article |
| 出版地 | LONDON |
| EISSN | 2055-0278 |
| 资助机构 | National Key R & D Program for Crop Breeding [2016YFD0100307] ; National Science Fund for Distinguished Young ScholarsNational Natural Science Foundation of China (NSFC)National Science Fund for Distinguished Young Scholars [31225025] ; National Program on Key Basic Research Projects in China (the 973 Program)National Basic Research Program of China [2012CB113900] ; leading talents of Guangdong province Program [00201515] ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31322047, 31401886, 31101550, 31672171] ; Science and Technology Innovation Program of the Chinese Academy of Agricultural Sciences (CAAS-ASTIP-IVFCAAS) ; Chinese Ministry of Finance [1251610601001] ; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2014M550902] ; Discovery Grant from National Science and Engineering Research Council of Canada (NSERC) ; Canada Research Chair programCanada Research Chairs ; UK Biotechnological and Biological Sciences Research Council Institute Strategic Programme Grant 'Understanding and Exploiting Plant and Microbial Metabolism' [BB/J004561/1] ; John Innes Foundation ; Genomes to Natural Products National Institutes of Health Programme [U01GM110699] ; Shenzhen Municipal Government ; Dapeng District Government ; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of General Medical Sciences (NIGMS) [U01GM110699] Funding Source: NIH RePORTER ; Biotechnology and Biological Sciences Research CouncilUK Research & Innovation (UKRI)Biotechnology and Biological Sciences Research Council (BBSRC) [BBS/E/J/000CA527, BB/L014130/1, BBS/E/J/00000614, BBS/E/J/000CA533] Funding Source: researchfish ; Engineering and Physical Sciences Research CouncilUK Research & Innovation (UKRI)Engineering & Physical Sciences Research Council (EPSRC) [EP/K034359/1] Funding Source: researchfish ; BBSRCUK Research & Innovation (UKRI)Biotechnology and Biological Sciences Research Council (BBSRC) [BB/L014130/1, BBS/E/J/000CA533, BBS/E/J/000CA527] Funding Source: UKRI ; EPSRCUK Research & Innovation (UKRI)Engineering & Physical Sciences Research Council (EPSRC) [EP/K034359/1] Funding Source: UKRI |
| 作者邮箱 | shangyi@caas.cn ; huangsanwen@caas.cn |
| 作品OA属性 | Green Accepted |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ibcas.ac.cn/handle/2S10CLM1/24955 |
| 专题 | 中科院植物分子生理学重点实验室 |
| 作者单位 | 1.Chinese Acad Agr Sci, Inst Vegetables & Flowers, Key Lab Biol & Genet Improvement Hort Crops, Minist Agr,Sinodutch Joint Lab Hort Genom, Beijing 100081, Peoples R China 2.Chinese Acad Agr Sci, Agr Genome Inst Shenzhen, Shenzhen 518124, Peoples R China 3.Hunan Agr Univ, Hort & Landscape Coll, Natl Chinese Med Herbs Hunan Technol Ctr, Changsha 410000, Hunan, Peoples R China 4.Chinese Acad Sci, Inst Bot, Beijing 100093, Peoples R China 5.Chinese Acad Agr Sci, Inst Apiculture Res, Beijing 100093, Peoples R China 6.Shanxi Univ, Sch Life Sci, Taiyuan 030006, Peoples R China 7.Peking Univ, Sch Pharmaceut Sci, Hlth Sci Ctr, Beijing 100191, Peoples R China 8.Huazhong Agr Univ, Coll Hort & Forestry Sci, Wuhan 430070, Peoples R China 9.John Innes Inst, Norwich Res Pk, Norwich NR4 7UH, Norfolk, England 10.Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Hunan, Peoples R China 11.Univ Calgary, Dept Biol Sci, Calgary, AB T2N 1N4, Canada |
| 推荐引用方式 GB/T 7714 | Zhou, Yuan,Ma, Yongshuo,Zeng, Jianguo,et al. Convergence and divergence of bitterness biosynthesis and regulation in Cucurbitaceae[J]. NATURE PLANTS,2016,2(12). |
| APA | Zhou, Yuan.,Ma, Yongshuo.,Zeng, Jianguo.,Duan, Lixin.,Xue, Xiaofeng.,...&Huang, Sanwen.(2016).Convergence and divergence of bitterness biosynthesis and regulation in Cucurbitaceae.NATURE PLANTS,2(12). |
| MLA | Zhou, Yuan,et al."Convergence and divergence of bitterness biosynthesis and regulation in Cucurbitaceae".NATURE PLANTS 2.12(2016). |
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| Zhou-2016-Convergenc（2975KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
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