A SAL1 Loss-of-Function Arabidopsis Mutant Exhibits Enhanced Cadmium Tolerance in Association with Alleviation of Endoplasmic Reticulum Stress

doi:10.1093/pcp/pcw069

	A SAL1 Loss-of-Function Arabidopsis Mutant Exhibits Enhanced Cadmium Tolerance in Association with Alleviation of Endoplasmic Reticulum Stress
	Xi, Hongmei 1; Xu, Hua 1; Xu, Wenxiu ; He, Zhenyan; Xu, Wenzhong ; Ma, Mi
	2016
发表期刊	PLANT AND CELL PHYSIOLOGY
ISSN	0032-0781
卷号	57 期号:6 页码:1210-1219
摘要	SAL1, as a negative regulator of stress response signaling, has been studied extensively for its role in plant response to environmental stresses. However, the role of SAL1 in cadmium (Cd) stress response and the underlying mechanism is still unclear. Using an Arabidopsis thaliana loss-of-function mutant of SAL1, we assessed Cd resistance and further explored the Cd toxicity mechanism through analysis of the endoplasmic reticulum (ER) stress response. The loss of SAL1 function greatly improved Cd tolerance and significantly attenuated ER stress in Arabidopsis. Exposure to Cd induced an ER stress response in Arabidopsis as evidenced by unconventional splicing of AtbZIP60 and up-regulation of ER stress-responsive genes. Damage caused by Cd was markedly reduced in the ER stress response double mutant bzip28 bzip60 or by application of the ER stress-alleviating chemical agents, tauroursodeoxycholic acid (TUDCA) and 4-phenyl butyric acid (4-PBA), in wild-type plants. The Cd-induced ER stress in Arabidopsis was also alleviated by loss of function of SAL1. These results identified SAL1 as a new component mediating Cd toxicity and established the role of the ER stress response in Cd toxicity. Additionally, the attenuated ER stress in the sal1 mutant might also shed new light on the mechanism of diverse abiotic stress resistance in the SAL1 loss-of-function mutants.
关键词	Arabidopsis Cadmium (Cd) tolerance Endoplasmic reticulum stress SAL1 Stress response
学科领域	Plant Sciences ; Cell Biology
DOI	10.1093/pcp/pcw069
收录类别	SCI
语种	英语
WOS关键词	UNFOLDED PROTEIN RESPONSE ; PROGRAMMED CELL-DEATH ; INOSITOL POLYPHOSPHATE 1-PHOSPHATASE ; TRANSCRIPTION FACTOR ; DROUGHT TOLERANCE ; 3(2),5-BISPHOSPHATE NUCLEOTIDASE ; NEGATIVE REGULATOR ; INDUCED APOPTOSIS ; GENE-EXPRESSION ; QUALITY CONTROL
WOS研究方向	Science Citation Index Expanded (SCI-EXPANDED)
WOS记录号	WOS:000379752100009
出版者	OXFORD UNIV PRESS
文献子类	Article
出版地	OXFORD
EISSN	1471-9053
资助机构	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31170164]
作者邮箱	xuwzh@ibcas.ac.cn ; mami@ibcas.ac.cn
作品OA属性	Bronze
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/25263
专题	中科院北方资源植物重点实验室
作者单位	1.Chinese Acad Sci, Inst Bot, Key Lab Plant Resources, Beijing 100093, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Xi, Hongmei,Xu, Hua,Xu, Wenxiu,et al. A SAL1 Loss-of-Function Arabidopsis Mutant Exhibits Enhanced Cadmium Tolerance in Association with Alleviation of Endoplasmic Reticulum Stress[J]. PLANT AND CELL PHYSIOLOGY,2016,57(6):1210-1219.
APA	Xi, Hongmei,Xu, Hua,Xu, Wenxiu,He, Zhenyan,Xu, Wenzhong,&Ma, Mi.(2016).A SAL1 Loss-of-Function Arabidopsis Mutant Exhibits Enhanced Cadmium Tolerance in Association with Alleviation of Endoplasmic Reticulum Stress.PLANT AND CELL PHYSIOLOGY,57(6),1210-1219.
MLA	Xi, Hongmei,et al."A SAL1 Loss-of-Function Arabidopsis Mutant Exhibits Enhanced Cadmium Tolerance in Association with Alleviation of Endoplasmic Reticulum Stress".PLANT AND CELL PHYSIOLOGY 57.6(2016):1210-1219.

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