IB-CAS  > 中科院光生物学重点实验室
DEG9, a serine protease, modulates cytokinin and light signaling by regulating the level of ARABIDOPSIS RESPONSE REGULATOR 4
Chi, Wei; Li, Jing; He, Baoye; Chai, Xin1; Xu, Xiumei; Sun, Xuwu; Jiang, Jingjing1; Feng, Peiqiang1; Zuo, Jianru2,3; Lin, Rongcheng; Rochaix, Jean-David; Zhang, Lixin
2016
Source PublicationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN0027-8424
Volume113Issue:25
AbstractCytokinin is an essential phytohormone that controls various biological processes in plants. A number of response regulators are known to be important for cytokinin signal transduction. ARABIDOPSIS RESPONSE REGULATOR 4 (ARR4) mediates the cross-talk between light and cytokinin signaling through modulation of the activity of phytochrome B. However, the mechanism that regulates the activity and stability of ARR4 is unknown. Here we identify an AT-Pindependent serine protease, degradation of periplasmic proteins 9 (DEG9), which localizes to the nucleus and regulates the stability of ARR4. Biochemical evidence shows that DEG9 interacts with ARR4, thereby targeting ARR4 for degradation, which suggests that DEG9 regulates the stability of ARR4. Moreover, genetic evidence shows that DEG9 acts upstream of ARR4 and regulates the activity of ARR4 in cytokinin and light-signaling pathways. This study thus identifies a role for a ubiquitin-independent selective protein proteolysis in the regulation of the stability of plant signaling components.
Keywordprotease cytokinins light DEG ARABIDOPSIS RESPONSE REGULATOR 4
Subject AreaMultidisciplinary Sciences
DOI10.1073/pnas.1601724113
Indexed BySCI
Language英语
WOS KeywordPHOTOSYSTEM-II ; B RESPONSE ; PHOSPHOTRANSFER PROTEINS ; 2-COMPONENT CIRCUITRY ; PROTEOMIC ANALYSIS ; PLANT PROTEASES ; GENE-EXPRESSION ; QUALITY CONTROL ; PHYTOCHROME-B ; D1 PROTEIN
WOS Research AreaScience Citation Index Expanded (SCI-EXPANDED)
WOS IDWOS:000378272400016
PublisherNATL ACAD SCIENCES
SubtypeArticle
Publication PlaceWASHINGTON
Funding OrganizationMajor State Basic Research Development ProgramNational Basic Research Program of China [2015CB150100] ; Ministry of Agriculture of ChinaMinistry of Agriculture, China [2014ZX08009-003-005] ; Key Research Program of the Chinese Academy of SciencesChinese Academy of Sciences
Corresponding Author Emailzhanglixin@ibcas.ac.cn
OAGreen Published, Bronze
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Document Type期刊论文
Identifierhttp://ir.ibcas.ac.cn/handle/2S10CLM1/25309
Collection中科院光生物学重点实验室
Affiliation1.Chinese Acad Sci, Inst Bot, Key Lab Photobiol, Photosynth Res Ctr, Beijing 100093, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Plant Genom, Beijing 100101, Peoples R China
4.Chinese Acad Sci, Inst Genet & Dev Biol, Natl Plant Gene Res Ctr, Beijing 100101, Peoples R China
5.Univ Geneva, Dept Mol Biol, CH-1211 Geneva, Switzerland
6.Univ Geneva, Dept Plant Biol, CH-1211 Geneva, Switzerland
Recommended Citation
GB/T 7714
Chi, Wei,Li, Jing,He, Baoye,et al. DEG9, a serine protease, modulates cytokinin and light signaling by regulating the level of ARABIDOPSIS RESPONSE REGULATOR 4[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2016,113(25).
APA Chi, Wei.,Li, Jing.,He, Baoye.,Chai, Xin.,Xu, Xiumei.,...&Zhang, Lixin.(2016).DEG9, a serine protease, modulates cytokinin and light signaling by regulating the level of ARABIDOPSIS RESPONSE REGULATOR 4.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,113(25).
MLA Chi, Wei,et al."DEG9, a serine protease, modulates cytokinin and light signaling by regulating the level of ARABIDOPSIS RESPONSE REGULATOR 4".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 113.25(2016).
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