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| A new two-dimensional chromatographic method for separation of saponins from steamed Panax notoginseng | |
| Lelu, Jimmy K.; Liu, Qi; Alolga, Raphael N.; Fan, Yong; Xiao, Wei-Lie; Qi, Lian-Wen; Li, Ping5 | |
| 2016 | |
| 发表期刊 | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
 |
| ISSN | 0731-7085 |
| 卷号 | 125页码:355-359 |
| 摘要 | The root and rhizome of Panax notoginseng (PNG) are used as folk medicine. Recent studies have reported PNG to possess immunomodulatory, cardioprotective, hepatoprotective, anti-diabetic and anticancer activities among a host of other pharmacological effects. The main active constituents responsible for these pharmacological effects are saponins. It has also been proven that the chemical constituents of steamed PNG differs from the raw form. Traditional methods of separating individual components in crude extracts are usually tedious, almost irreproducible and time-consuming. In this study, an automated multi-step preparative separation system, known as Sepbox afforded a quick, reproducible and fast separation of saponins from PNG. With Sepbox, a total of 11 saponins of high purity were obtained in a short period of time. The separated compounds were identified as notoginsenosides R1, T5, ginsenosides Rb1, Rg1, Rg2, Rh1, Rh4, Rd, 20 (S) -Rg3 and a mixture of ginsenosides Rk1 and Rg5. (C) 2016 Elsevier B.V. All rights reserved. |
| 关键词 | Panax notoginseng Saponins Sepbox Rare ginsenosides |
| 学科领域 | Chemistry, Analytical ; Pharmacology & Pharmacy |
| DOI | 10.1016/j.jpba.2016.04.019 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Science Citation Index Expanded (SCI-EXPANDED) |
| WOS记录号 | WOS:000376474400042 |
| 出版者 | ELSEVIER |
| 文献子类 | Article |
| 出版地 | AMSTERDAM |
| EISSN | 1873-264X |
| 作者邮箱 | xlw@mail.kib.ac.cn ; Qilw@cpu.edu.cn ; liping2004@126.com |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ibcas.ac.cn/handle/2S10CLM1/25374 |
| 专题 | 中科院植物分子生理学重点实验室 |
| 作者单位 | 1.[Lelu, Jimmy K. 2.Liu, Qi 3.Alolga, Raphael N. 4.Fan, Yong 5.Qi, Lian-Wen 6.China Pharmaceut Univ, State Key Lab Nat Med, 24 Tongjia Lane, Nanjing 210009, Jiangsu, Peoples R China 7.Chinese Acad Sci, Kunming Inst Bot, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lelu, Jimmy K.,Liu, Qi,Alolga, Raphael N.,et al. A new two-dimensional chromatographic method for separation of saponins from steamed Panax notoginseng[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2016,125:355-359. |
| APA | Lelu, Jimmy K..,Liu, Qi.,Alolga, Raphael N..,Fan, Yong.,Xiao, Wei-Lie.,...&Li, Ping.(2016).A new two-dimensional chromatographic method for separation of saponins from steamed Panax notoginseng.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,125,355-359. |
| MLA | Lelu, Jimmy K.,et al."A new two-dimensional chromatographic method for separation of saponins from steamed Panax notoginseng".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 125(2016):355-359. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| 27107214.pdf（885KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
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