O-linked beta-N-acetylglucosamine modification and its biological functions

doi:10.1007/s11434-015-0816-x

	O-linked beta-N-acetylglucosamine modification and its biological functions
	Liu, Yan 1; Dai, Shaojun ; Xing, Lijing 1; Xu, Yunyuan 1; Chong, Kang 1
	2015
发表期刊	SCIENCE BULLETIN
ISSN	2095-9273
卷号	60 期号:12 页码:1055-1061
摘要	The covalent attachment of O-linked beta-N-acetylglucosamine (O-GlcNAc) to Ser/Thr residues of proteins acts as not only a posttranslational modification but also a nutritional sensor in nucleus and cytoplasm, which directly regulates the expression of genes and multiple crucial signal transduction pathways. Dynamic O-GlcNAcylation at Ser/Thr residues is catalyzed by two key enzymes, O-GlcNAc transferase (OGT) and O-GlcNAcase, which are responsible for addition and removal of the O-GlcNAc modification, respectively. O-GlcNAc modification plays important roles in cellular signaling in animals, especially in human diseases. Two orthologs of OGT in plants, SECRET AGENT and SPINDLY, have been reported to be involved in diverse plant processes. However, compared with the functional mechanisms revealed in animals, the consequences of protein O-GlcNAc modification in plants is largely unknown, and the relationship between O-GlcNAcylation and cellular processes needs to be explored. In this review, we summarized the recent advances on O-GlcNAc modification and its biological functions in animals and plants, and prospect of more special functions of O-GlcNAc will be revealed in plants.
关键词	O-GlcNAc Posttranslational modification Epigenetic regulation Plants
学科领域	Multidisciplinary Sciences
DOI	10.1007/s11434-015-0816-x
收录类别	SCI
语种	英语
WOS关键词	POLYCOMB GROUP PROTEINS ; VIRUS CAPSID PROTEIN ; REPRESSIVE COMPLEX 2 ; GLCNAC TRANSFERASE ; SECRET-AGENT ; TETRATRICOPEPTIDE REPEATS ; STRESS-RESPONSE ; CARDIOVASCULAR-SYSTEM ; SUBSTRATE-SPECIFICITY ; CYTOSOLIC PROTEINS
WOS研究方向	Science Citation Index Expanded (SCI-EXPANDED)
WOS记录号	WOS:000356538300001
出版者	SCIENCE PRESS
文献子类	Review
出版地	BEIJING
EISSN	2095-9281
作者邮箱	daishaojun@hotmail.com ; xinglijing@ibcas.ac.cn
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/25577
专题	中科院植物分子生理学重点实验室
作者单位	1.Northeast Forestry Univ, Alkali Soil Nat Environm Sci Ctr, Key Lab Saline Alkali Vegetat Ecol Restorat Oil F, Minist Educ, Harbin 150040, Peoples R China 2.Chinese Acad Sci, Inst Bot, Key Lab Plant Mol Physiol, Beijing 100093, Peoples R China
推荐引用方式 GB/T 7714	Liu, Yan,Dai, Shaojun,Xing, Lijing,et al. O-linked beta-N-acetylglucosamine modification and its biological functions[J]. SCIENCE BULLETIN,2015,60(12):1055-1061.
APA	Liu, Yan,Dai, Shaojun,Xing, Lijing,Xu, Yunyuan,&Chong, Kang.(2015).O-linked beta-N-acetylglucosamine modification and its biological functions.SCIENCE BULLETIN,60(12),1055-1061.
MLA	Liu, Yan,et al."O-linked beta-N-acetylglucosamine modification and its biological functions".SCIENCE BULLETIN 60.12(2015):1055-1061.

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