Anillin Regulates Neuronal Migration and Neurite Growth by Linking RhoG to the Actin Cytoskeleton

doi:10.1016/j.cub.2015.02.072

	Anillin Regulates Neuronal Migration and Neurite Growth by Linking RhoG to the Actin Cytoskeleton
	Tian, Dong ; Diao, Min 1; Jiang, Yuxiang 1; Sun, Lingfei ; Zhang, Yan ; Chen, Zhucheng ; Huang, Shanjin 1; Ou, Guangshuo
	2015
发表期刊	CURRENT BIOLOGY
ISSN	0960-9822
卷号	25 期号:9 页码:1135-1145
摘要	Neuronal migration and neurite growth are essential events in neural development, but it remains unclear how guidance cues are transduced through receptors to the actin cytoskeleton, which powers these processes. We report that a cytokinetic scaffold protein, Anillin, is redistributed to the leading edge of the C. elegans Q neuroblast during cell migration and neurite growth. To bypass the requirement for Anillin in cytokinesis, we used the somatic CRISPR-Cas9 technique to generate conditional mutations in Anillin. We demonstrate that Anillin regulates cell migration and growth cone extension by stabilizing the F-actin network at the leading edge. Our biochemical analysis shows that the actin-binding domain of Anillin is sufficient to stabilize F-actin by antagonizing the F-actin severing activity of Cofilin. We further uncover that the active form of RhoG/MIG-2 directly binds to Anillin and recruits it to the leading edge. Our results reveal a novel pathway in which Anillin transduces the RhoG signal to the actin cytoskeleton during neuronal migration and neurite growth.
学科领域	Biochemistry & Molecular Biology ; Biology ; Cell Biology
DOI	10.1016/j.cub.2015.02.072
收录类别	SCI
语种	英语
WOS关键词	BINDING PROTEIN ANILLIN ; CAENORHABDITIS-ELEGANS ; C. ELEGANS ; CELL-MIGRATION ; CYTOKINESIS ; MYOSIN ; FILAMENTS ; COMPLEX ; ROLES ; STAGE
WOS研究方向	Science Citation Index Expanded (SCI-EXPANDED)
WOS记录号	WOS:000353999000020
出版者	CELL PRESS
文献子类	Article
出版地	CAMBRIDGE
EISSN	1879-0445
资助机构	National Basic Research Program of China (973 Program) [2013CB945600, 2012CB945002] ; National Natural Science Foundation of China [31222035, 31171295, 31190063, 31125004, 31270762] ; Junior Thousand Talents Program of China
作者邮箱	guangshuoou@mail.tsinghua.edu.cn
作品OA属性	Bronze
引用统计	被引频次：44[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/25587
专题	中科院植物分子生理学重点实验室
作者单位	1.Tsinghua Univ, Sch Life Sci, Tsinghua Peking Ctr Life Sci, Beijing 100084, Peoples R China 2.Chinese Acad Sci, Inst Bot, Key Lab Plant Mol Physiol, Beijing 100093, Peoples R China
推荐引用方式 GB/T 7714	Tian, Dong,Diao, Min,Jiang, Yuxiang,et al. Anillin Regulates Neuronal Migration and Neurite Growth by Linking RhoG to the Actin Cytoskeleton[J]. CURRENT BIOLOGY,2015,25(9):1135-1145.
APA	Tian, Dong.,Diao, Min.,Jiang, Yuxiang.,Sun, Lingfei.,Zhang, Yan.,...&Ou, Guangshuo.(2015).Anillin Regulates Neuronal Migration and Neurite Growth by Linking RhoG to the Actin Cytoskeleton.CURRENT BIOLOGY,25(9),1135-1145.
MLA	Tian, Dong,et al."Anillin Regulates Neuronal Migration and Neurite Growth by Linking RhoG to the Actin Cytoskeleton".CURRENT BIOLOGY 25.9(2015):1135-1145.

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