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An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors
Jin, Jinpu; He, Kun1; Tang, Xing; Li, Zhe2; Lv, Le1; Zhao, Yi; Luo, Jingchu; Gao, Ge
2015
发表期刊MOLECULAR BIOLOGY AND EVOLUTION
ISSN0737-4038
卷号32期号:7页码:1767-1773
摘要Transcription factors (TFs) play key roles in both development and stress responses. By integrating into and rewiring original systems, novel TFs contribute significantly to the evolution of transcriptional regulatory networks. Here, we report a high-confidence transcriptional regulatory map covering 388 TFs from 47 families in Arabidopsis. Systematic analysis of this map revealed the architectural heterogeneity of developmental and stress response subnetworks and identified three types of novel network motifs that are absent from unicellular organisms and essential for multicellular development. Moreover, TFs of novel families that emerged during plant landing present higher binding specificities and are preferentially wired into developmental processes and these novel network motifs. Further unveiled connection between the binding specificity and wiring preference of TFs explains the wiring preferences of novel-family TFs. These results reveal distinct functional and evolutionary features of novel TFs, suggesting a plausible mechanism for their contribution to the evolution of multicellular organisms.
关键词transcription factor transcriptional regulation network structure novel family wiring preference
学科领域Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
DOI10.1093/molbev/msv058
收录类别SCI
语种英语
WOS关键词FLORAL HOMEOTIC GENES ; NETWORK MOTIFS ; ESCHERICHIA-COLI ; GENOMIC ANALYSIS ; FACTOR-BINDING ; DYNAMICS ; ARCHITECTURE ; PLANT ; BACTERIA ; CIRCUITS
WOS研究方向Science Citation Index Expanded (SCI-EXPANDED)
WOS记录号WOS:000360585900009
出版者OXFORD UNIV PRESS
文献子类Article
出版地OXFORD
EISSN1537-1719
资助机构National Natural Science Foundation of China [31470330] ; China 863 Programs [2006AA02Z334] ; State Key Laboratory of Protein and Plant Gene Research ; National Program for Support of Top-notch Young Professionals ; China Postdoctoral Science Foundation [2014M560017]
作者邮箱gaog@mail.cbi.pku.edu.cn
作品OA属性hybrid, Green Published
引用统计
被引频次:113[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ibcas.ac.cn/handle/2S10CLM1/25666
专题系统与进化植物学国家重点实验室
作者单位1.Peking Univ, Ctr Bioinformat, Coll Life Sci, State Key Lab Prot & Plant Gene Res, Beijing 100871, Peoples R China
2.Monsanto Biotechnol R&D Ctr, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Bot, State Key Lab Systemat & Evolutionary Bot, Beijing, Peoples R China
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Jin, Jinpu,He, Kun,Tang, Xing,et al. An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors[J]. MOLECULAR BIOLOGY AND EVOLUTION,2015,32(7):1767-1773.
APA Jin, Jinpu.,He, Kun.,Tang, Xing.,Li, Zhe.,Lv, Le.,...&Gao, Ge.(2015).An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors.MOLECULAR BIOLOGY AND EVOLUTION,32(7),1767-1773.
MLA Jin, Jinpu,et al."An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors".MOLECULAR BIOLOGY AND EVOLUTION 32.7(2015):1767-1773.
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