Autoxidated linolenic acid inhibits aflatoxin biosynthesis in Aspergillus flavus via oxylipin species

doi:10.1016/j.fgb.2014.11.005

	Autoxidated linolenic acid inhibits aflatoxin biosynthesis in Aspergillus flavus via oxylipin species
	Yan, Shijuan ; Liang, Yating ; Zhang, Jindan ; Chen, Zhuang ; Liu, Chun-Ming
	2015
发表期刊	FUNGAL GENETICS AND BIOLOGY
ISSN	1087-1845
卷号	81 页码:229-237
摘要	Aflatoxins produced by Aspergillus species are among the most toxic and carcinogenic compounds in nature. Although it has been known for a long time that seeds with high oil content are more susceptible to aflatoxin contamination, the role of fatty acids in aflatoxin biosynthesis remains controversial. Here we demonstrate in A. flavus that both the saturated stearic acid (C18:0) and the polyunsaturated linolenic acid (C18:3) promoted aflatoxin production, while C18:3, but not C18:0, inhibited aflatoxin biosynthesis after exposure to air for several hours. Further experiments showed that autoxidated C18:3 promoted mycelial growth, sporulation, and kojic acid production, but inhibited the expression of genes in the AF biosynthetic gene cluster. Mass spectrometry analyses of autoxidated C18:3 fractions that were able to inhibit aflatoxin biosynthesis led to the identification of multiple oxylipin species. These results may help to clarify the role of fatty acids in aflatoxin biosynthesis, and may explain why controversial results have been obtained for fatty acids in the past. (C) 2014 Elsevier Inc. All rights reserved.
关键词	Linolenic acid Autoxidation Oxylipins Inhibition Aflatoxin production Aspergillus flavus
学科领域	Genetics & Heredity ; Mycology
DOI	10.1016/j.fgb.2014.11.005
收录类别	SCI
语种	英语
WOS关键词	FATTY-ACIDS ; MYCOTOXIN PRODUCTION ; B-1 PRODUCTION ; KOJIC ACID ; GROWTH ; PARASITICUS ; LIPIDS ; LIPOPEROXIDATION ; EXPRESSION
WOS研究方向	Science Citation Index Expanded (SCI-EXPANDED)
WOS记录号	WOS:000359885200024
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
文献子类	Article
出版地	SAN DIEGO
EISSN	1096-0937
资助机构	CAS [KSCX2-YW-N-033]
作者邮箱	cmliu@ibcas.ac.cn
引用统计	被引频次：27[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/25707
专题	中科院植物分子生理学重点实验室
作者单位	1.Guangdong Acad Agr Sci, Agrobiol Gene Res Ctr, Guangzhou 510640, Peoples R China 2.Chinese Acad Sci, Inst Bot, Key Lab Plant Mol Physiol, Beijing 100093, Peoples R China
推荐引用方式 GB/T 7714	Yan, Shijuan,Liang, Yating,Zhang, Jindan,et al. Autoxidated linolenic acid inhibits aflatoxin biosynthesis in Aspergillus flavus via oxylipin species[J]. FUNGAL GENETICS AND BIOLOGY,2015,81:229-237.
APA	Yan, Shijuan,Liang, Yating,Zhang, Jindan,Chen, Zhuang,&Liu, Chun-Ming.(2015).Autoxidated linolenic acid inhibits aflatoxin biosynthesis in Aspergillus flavus via oxylipin species.FUNGAL GENETICS AND BIOLOGY,81,229-237.
MLA	Yan, Shijuan,et al."Autoxidated linolenic acid inhibits aflatoxin biosynthesis in Aspergillus flavus via oxylipin species".FUNGAL GENETICS AND BIOLOGY 81(2015):229-237.

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