Historical and experimental evidence for enhanced concentration of artemesinin, a global anti-malarial treatment, with recent and projected increases in atmospheric carbon dioxide

doi:10.1007/s10584-015-1421-3

	Historical and experimental evidence for enhanced concentration of artemesinin, a global anti-malarial treatment, with recent and projected increases in atmospheric carbon dioxide
	Zhu, C.; Zeng, Q.; McMichael, A.; Ebi, K. L.; Ni, K.; Khan, A. S.; Zhu, J.; Liu, G.; Zhang, X.; Cheng, Lei 6; Ziska, L. H.
	2015
发表期刊	CLIMATIC CHANGE
ISSN	0165-0009
卷号	132 期号:2 页码:295-306
摘要	Although the role of rising atmospheric carbon dioxide concentration [CO2] on plant growth and fecundity is widely acknowledged as important within the scientific community; less research is available regarding the impact of [CO2] on secondary plant compounds, even though such compounds can play a significant role in human health. At present, Artemisia annua, an annual plant species native to China, is widely recognized as the primary source of artemesinin used in artemesinin combination therapies or ACTs. ACTs, in turn, are used globally for the treatment of simple Plasmodium falciparum malaria, the predominant form of malaria in Africa. In this study, artemesinin concentration was quantified for multiple A. annua populations in China using a free-air CO2 enrichment (FACE) system as a function of [CO2]-induced changes both in situ and as a function of the foliar ratio of carbon to nitrogen (C:N). The high correlation between artemesinin concentration and C:N allowed an historical examination of A. annua leaves collected at 236 locations throughout China from 1905 through 2009. Both the historical and experimental data indicate that increases in artemesinin foliar concentration are likely to continue in parallel with the ongoing increase in atmospheric [CO2]. The basis for the [CO2]-induced increase in artemesinin is unclear, but could be related to the carbon: nutrient hypothesis of Bryant et al. (1983). Overall, these data provide the first evidence that historic and projected increases in atmospheric [CO2] may be associated with global changes in artemesinin chemistry, potentially allowing a greater quantity of drug available for the same area of cultivation.
学科领域	Environmental Sciences ; Meteorology & Atmospheric Sciences
DOI	10.1007/s10584-015-1421-3
收录类别	SCI
语种	英语
WOS关键词	PLANT-HERBIVORE INTERACTIONS ; ELEVATED CO2 ; ARTEMISIA-ANNUA ; CLIMATE-CHANGE ; NITROGEN ; MALARIA ; GROWTH ; OPTIMIZATION ; TEMPERATURE ; CHALLENGES
WOS研究方向	Science Citation Index Expanded (SCI-EXPANDED)
WOS记录号	WOS:000360541800010
出版者	SPRINGER
文献子类	Article
出版地	DORDRECHT
EISSN	1573-1480
资助机构	National Basic Research Program (973 Program) [2014CB954500] ; National Natural Science Foundation of China [31370457, 41301209, 31261140364, 31201126] ; Natural Science Foundation of Jiangsu province in China [BK20131051, BK20140063]
作者邮箱	cwzhu@issas.ac.cn ; zql522@sina.cn ; tony.mcmichael@anu.edu.au ; krisebi@essllc.org ; ali.khan@unmc.edu ; zhangxc@ibcas.ac.cn ; lcheng@zju.edu.cn ; l.ziska@ars.usda.gov
作品OA属性	Green Submitted
引用统计	被引频次：10[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/25752
专题	系统与进化植物学国家重点实验室
作者单位	1.[Zhu, C.; Ni, K.; Zhu, J.; Liu, G.] Chinese Acad Sci, State Key Lab Soil & Sustainable Agr, Nanjing 210008, Jiangsu, Peoples R China 2.Zeng, Q.] Chinese Acad Sci, Jiangsu Inst Bot, Nanjing Bot Garden, Nanjing 210014, Jiangsu, Peoples R China 3.McMichael, A.] Australian Natl Univ, Coll Med Biol & Environm, Canberra, ACT, Australia 4.Ebi, K. L.] Univ Washington, Sch Publ Hlth, Seattle, WA 98195 USA 5.Khan, A. S.] Univ Nebraska, Med Ctr, Coll Publ Hlth, Omaha, NE 68198 USA 6.Zhang, X.] Chinese Acad Sci, Inst Bot, Herbarium, State Key Lab Systemat & Evolutionary Bot, Beijing 100093, Peoples R China 7.Zhejiang Univ, Coll Life Sci, Hangzhou 310058, Zhejiang, Peoples R China 8.Ziska, L. H.] USDA ARS, Crop Syst & Global Change Lab, Beltsville, MD 20705 USA
推荐引用方式 GB/T 7714	Zhu, C.,Zeng, Q.,McMichael, A.,et al. Historical and experimental evidence for enhanced concentration of artemesinin, a global anti-malarial treatment, with recent and projected increases in atmospheric carbon dioxide[J]. CLIMATIC CHANGE,2015,132(2):295-306.
APA	Zhu, C..,Zeng, Q..,McMichael, A..,Ebi, K. L..,Ni, K..,...&Ziska, L. H..(2015).Historical and experimental evidence for enhanced concentration of artemesinin, a global anti-malarial treatment, with recent and projected increases in atmospheric carbon dioxide.CLIMATIC CHANGE,132(2),295-306.
MLA	Zhu, C.,et al."Historical and experimental evidence for enhanced concentration of artemesinin, a global anti-malarial treatment, with recent and projected increases in atmospheric carbon dioxide".CLIMATIC CHANGE 132.2(2015):295-306.

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