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PAB is an assembly chaperone that functions downstream of chaperonin 60 in the assembly of chloroplast ATP synthase coupling factor 1 | |
Mao, Juan1; Chi, Wei; Ouyang, Min; He, Baoye1; Chen, Fan2; Zhang, Lixin | |
2015 | |
发表期刊 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA |
ISSN | 0027-8424 |
卷号 | 112期号:13页码:4152-4157 |
摘要 | The chloroplast ATP synthase, a multisubunit complex in the thylakoid membrane, catalyzes the light-driven synthesis of ATP, thereby supplying the energy for carbon fixation during photosynthesis. The chloroplast ATP synthase is composed of both nucleus-and chloroplast-encoded proteins that have required the evolution of novel mechanisms to coordinate the biosynthesis and assembly of chloroplast ATP synthase subunits temporally and spatially. Here we have elucidated the assembly mechanism of the alpha(3)beta(3)gamma core complex of the chloroplast ATP synthase by identification and functional characterization of a key assembly factor, PAB (PROTEIN IN CHLOROPLAST ATPASE BIOGENESIS). PAB directly interacts with the nucleus-encoded gamma subunit and functions downstream of chaperonin 60 (Cpn60)-mediated CF1 gamma subunit folding to promote its assembly into the catalytic core. PAB does not have any recognizable motifs or domains but is conserved in photosynthetic eukaryotes. It is likely that PAB evolved together with the transfer of chloroplast genes into the nucleus to assist nucleus-encoded CF1 gamma assembly into the CF1 core. Such coordination might represent an evolutionarily conserved mechanism for folding and assembly of nucleus-encoded proteins to ensure proper assembly of multiprotein photosynthetic complexes. |
关键词 | assembly ATP synthase chloroplast Cpn60 |
学科领域 | Multidisciplinary Sciences |
DOI | 10.1073/pnas.1413392111 |
收录类别 | SCI |
语种 | 英语 |
WOS关键词 | ARABIDOPSIS-THALIANA ; MOLECULAR CHAPERONES ; PHOTOSYSTEM-II ; IN-VIVO ; HEXADECAMERIC RUBISCO ; GENE-EXPRESSION ; GAMMA-SUBUNIT ; PROTEIN ; GROES ; PHOTOPHOSPHORYLATION |
WOS研究方向 | Science Citation Index Expanded (SCI-EXPANDED) |
WOS记录号 | WOS:000351914500083 |
出版者 | NATL ACAD SCIENCES |
文献子类 | Article |
出版地 | WASHINGTON |
资助机构 | National Natural Science Foundation of China [31130059] ; Major State Basic Research Development Program [2012CB917300] ; Solar Energy Initiative and Cooperative Team Project of the Chinese Academy of Sciences |
作者邮箱 | zhanglixin@ibcas.ac.cn |
作品OA属性 | Bronze, Green Published |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ibcas.ac.cn/handle/2S10CLM1/25801 |
专题 | 中科院光生物学重点实验室 |
作者单位 | 1.Chinese Acad Sci, Inst Bot, Photosynth Res Ctr, Key Lab Photobiol, Beijing 100093, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing 100086, Peoples R China |
推荐引用方式 GB/T 7714 | Mao, Juan,Chi, Wei,Ouyang, Min,et al. PAB is an assembly chaperone that functions downstream of chaperonin 60 in the assembly of chloroplast ATP synthase coupling factor 1[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2015,112(13):4152-4157. |
APA | Mao, Juan,Chi, Wei,Ouyang, Min,He, Baoye,Chen, Fan,&Zhang, Lixin.(2015).PAB is an assembly chaperone that functions downstream of chaperonin 60 in the assembly of chloroplast ATP synthase coupling factor 1.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,112(13),4152-4157. |
MLA | Mao, Juan,et al."PAB is an assembly chaperone that functions downstream of chaperonin 60 in the assembly of chloroplast ATP synthase coupling factor 1".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112.13(2015):4152-4157. |
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