In Search of Beneficial Coding RNA Editing

doi:10.1093/molbev/msu314

	In Search of Beneficial Coding RNA Editing
	Xu, Guixia; Zhang, Jianzhi 1
	2015
发表期刊	MOLECULAR BIOLOGY AND EVOLUTION
ISSN	0737-4038
卷号	32 期号:2 页码:536-541
摘要	RNA editing is a posttranscriptional modification that can lead to a change in the encoded protein sequence of a gene. Although a few cases of mammalian coding RNA editing are known to be functionally important, the vast majority of over 2,000 A-to-I editing sites that have been identified from the coding regions of the human genome are likely nonadaptive, representing tolerable promiscuous targeting of editing enzymes. Finding the potentially tiny fraction of beneficial editing sites from the sea of mostly nearly neutral editing is a difficult but important task. Here, we propose and provide evidence that evolutionarily conserved or hardwired residues that experience high-level nonsynonymous RNA editing in a species are enriched with beneficial editing. This simple approach allows the prediction of sites where RNA editing is functionally important. We suggest that priority be given to these candidates in future characterizations of the functional and fitness consequences of RNA editing.
关键词	editing level evolution human nonsynonymous
学科领域	Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
DOI	10.1093/molbev/msu314
收录类别	SCI
语种	英语
WOS关键词	ACCURATE IDENTIFICATION ; SEQUENCING DATA ; SEQ DATA ; SITES ; TRANSCRIPTOME ; DROSOPHILA ; TARGETS
WOS研究方向	Science Citation Index Expanded (SCI-EXPANDED)
WOS记录号	WOS:000350050700019
出版者	OXFORD UNIV PRESS
文献子类	Article
出版地	OXFORD
EISSN	1537-1719
资助机构	US National Institutes of Health [R01GM103232] ; National Natural Science Foundation of China [31100170] ; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM103232] Funding Source: NIH RePORTER
作者邮箱	jianzhi@umich.edu
作品OA属性	Bronze, Green Published
引用统计	被引频次：25[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/25840
专题	系统与进化植物学国家重点实验室
作者单位	1.Chinese Acad Sci, Inst Bot, State Key Lab Systemat & Evolutionary Bot, Beijing, Peoples R China 2.Univ Michigan, Dept Ecol & Evolutionary Biol, Ann Arbor, MI 48109 USA
推荐引用方式 GB/T 7714	Xu, Guixia,Zhang, Jianzhi. In Search of Beneficial Coding RNA Editing[J]. MOLECULAR BIOLOGY AND EVOLUTION,2015,32(2):536-541.
APA	Xu, Guixia,&Zhang, Jianzhi.(2015).In Search of Beneficial Coding RNA Editing.MOLECULAR BIOLOGY AND EVOLUTION,32(2),536-541.
MLA	Xu, Guixia,et al."In Search of Beneficial Coding RNA Editing".MOLECULAR BIOLOGY AND EVOLUTION 32.2(2015):536-541.

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