A single-nucleotide exon found in Arabidopsis

doi:10.1038/srep18087

	A single-nucleotide exon found in Arabidopsis
	Guo, Lei 1; Liu, Chun-Ming
	2015
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	5
摘要	Most eukaryotic genes carry protein-coding exons that are separated by non-coding introns(1,2). Pre-mRNA splicing is performed by the spliceosome, a large ribonucleoprotein complex comprised of five small nuclear ribonucleoproteins (snRNPs U1, U2, U4, U5 and U6) and a large number of associated proteins(3,4). The size of introns ranges from 13 to over 300,000 nucleotides(5,6). Sufficient evidence suggest that intronic sequences not only determine the splicing pattern(7), but also have regulatory functions in gene expression(8). Although most known regulatory sequences including the conserved GT and AG located at the beginning and the end of introns, respectively, an A at the branch point and a pyrimidine tract in spliceosome-binding and intron splicing are located in introns(9), exonic sequences play an important role in accurate splicing as well(10-12). The average size of exons is approximately 130 nucleotides in vertebrates, and 180 nucleotides in plants(13). Studies have showed that exons with less than 51 nucleotides may cause exon skipping, and exons that are too small in size may hinder the recognition of adjacent spliceosome binding(14-17). However, internal micro-exons with less than 25 nucleotides have been identified in different eukaryotic organisms by sequencing and computational analyses(18,19). The smallest naturally available exon that has been experimentally characterized so far has 3 nucleotides(16,20). Here we report the identification of a single-nucleotide exon in Arabidopsis.
学科领域	Multidisciplinary Sciences
DOI	10.1038/srep18087
收录类别	SCI
语种	英语
WOS关键词	PRE-MESSENGER-RNAS ; SPLICE-SITE ; INTRON ; SELECTION ; MECHANISMS ; INCLUSION ; SEQUENCE ; PROGRAM ; LENGTH
WOS研究方向	Science Citation Index Expanded (SCI-EXPANDED)
WOS记录号	WOS:000366131700001
出版者	NATURE PUBLISHING GROUP
文献子类	Article
出版地	LONDON
资助机构	Mechanistic dissection of plant embryo and seed development project of the National Basic Research Program of China [2014CB943400] ; Dutch-China Collaborative Project of NNFC [31161130531]
作者邮箱	cmliu@ibcas.ac.cn
作品OA属性	Green Published, gold
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/25926
专题	中科院植物分子生理学重点实验室
作者单位	1.Chinese Acad Sci, Inst Bot, Key Lab Plant Mol Physiol, Beijing 100093, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Guo, Lei,Liu, Chun-Ming. A single-nucleotide exon found in Arabidopsis[J]. SCIENTIFIC REPORTS,2015,5.
APA	Guo, Lei,&Liu, Chun-Ming.(2015).A single-nucleotide exon found in Arabidopsis.SCIENTIFIC REPORTS,5.
MLA	Guo, Lei,et al."A single-nucleotide exon found in Arabidopsis".SCIENTIFIC REPORTS 5(2015).

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