BBX19 fine-tunes the circadian rhythm by interacting with PSEUDO-RESPONSE REGULATOR proteins to facilitate their repressive effect on morning-phased clock genes

doi:10.1093/plcell/koab133

	BBX19 fine-tunes the circadian rhythm by interacting with PSEUDO-RESPONSE REGULATOR proteins to facilitate their repressive effect on morning-phased clock genes
	Yuan, Li ; Yu, Yingjun 1,2; Liu, Mingming ; Song, Yang ; Li, Hongmin ; Sun, Junqiu ; Wang, Qiao 3; Xie, Qiguang ; Wang, Lei1 ; Xu, Xiaodong
	2021
发表期刊	PLANT CELL
ISSN	1040-4651
卷号	33 期号:8 页码:2602-2617
摘要	The core plant circadian oscillator is composed of multiple interlocked transcriptional-translational feedback loops, which synchronize endogenous diel physiological rhythms to the cyclic changes of environmental cues. PSEUDO-RESPONSE REGULATORS (PRRs) have been identified as negative components in the circadian clock, though their underlying molecular mechanisms remain largely unknown. Here, we found that a subfamily of zinc finger transcription factors, B-box (BBX)-containing proteins, have a critical role in fine-tuning circadian rhythm. We demonstrated that overexpressing Arabidopsis thaliana BBX19 and BBX18 significantly lengthened the circadian period, while the null mutation of BBX19 accelerated the circadian speed. Moreover, BBX19 and BBX18, which are expressed during the day, physically interacted with PRR9, PRR7, and PRR5 in the nucleus in precise temporal ordering from dawn to dusk, consistent with the respective protein accumulation pattern of PRRs. Our transcriptomic and genetic analysis indicated that BBX19 and PRR9, PRR7, and PRR5 cooperatively inhibited the expression of morning-phased clock genes. PRR proteins affected BBX19 recruitment to the CCA1, LHY, and RVE8 promoters. Collectively, our findings show that BBX19 interacts with PRRs to orchestrate circadian rhythms, and suggest the indispensable role of transcriptional regulators in fine-tuning the circadian clock.
学科领域	Biochemistry & Molecular Biology ; Plant Sciences ; Cell Biology
DOI	10.1093/plcell/koab133
收录类别	SCI
语种	英语
WOS关键词	B-BOX PROTEIN ; TRANSCRIPTIONAL REPRESSION ; FLOWERING TIME ; ARABIDOPSIS ; ELF3 ; LIGHT ; CCA1 ; HY5 ; EXPRESSION ; COP1
WOS研究方向	Science Citation Index Expanded (SCI-EXPANDED)
WOS记录号	WOS:000696248800012
出版者	OXFORD UNIV PRESS INC
文献子类	Article
出版地	CARY
EISSN	1532-298X
资助机构	National Natural Science Foundation of China [U1904202, 31570285, 31670285, 31570292] ; Natural Science Foundation of Hebei [17966304D] ; Hebei Hundred Talents Program [E2016100018] ; Strategic Priority Research Program of the Chinese Academy of Sciences [XDB27030206]
作者邮箱	qiguang.xie@henu.edu.cn ; wanglei@ibcas.ac.cn ; xiaodong.xu@henu.edu.cn
作品OA属性	Green Published, hybrid
引用统计	被引频次：33[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/26414
专题	中科院植物分子生理学重点实验室
作者单位	1.Henan Univ, Sch Life Sci, State Key Lab Crop Stress Adaptat & Improvement, Kaifeng 475004, Peoples R China 2.Chinese Acad Sci, CAS Ctr Excellence Mol Plant Sci, Inst Bot, Key Lab Plant Mol Physiol, Beijing 100093, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Hebei Normal Univ, Coll Life Sci, Shijiazhuang 050024, Hebei, Peoples R China
推荐引用方式 GB/T 7714	Yuan, Li,Yu, Yingjun,Liu, Mingming,et al. BBX19 fine-tunes the circadian rhythm by interacting with PSEUDO-RESPONSE REGULATOR proteins to facilitate their repressive effect on morning-phased clock genes[J]. PLANT CELL,2021,33(8):2602-2617.
APA	Yuan, Li.,Yu, Yingjun.,Liu, Mingming.,Song, Yang.,Li, Hongmin.,...&Xu, Xiaodong.(2021).BBX19 fine-tunes the circadian rhythm by interacting with PSEUDO-RESPONSE REGULATOR proteins to facilitate their repressive effect on morning-phased clock genes.PLANT CELL,33(8),2602-2617.
MLA	Yuan, Li,et al."BBX19 fine-tunes the circadian rhythm by interacting with PSEUDO-RESPONSE REGULATOR proteins to facilitate their repressive effect on morning-phased clock genes".PLANT CELL 33.8(2021):2602-2617.

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