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SDC mediates DNA methylation-controlled clock pace by interacting with ZTL in Arabidopsis | |
Tian, Wenwen1; Wang, Ruyi; Bo, Cunpei1; Yu, Yingjun1; Zhang, Yuanyuan; Shin, Gyeong-Im; Kim, Woe-Yeon; Wang, Lei1 | |
2021 | |
发表期刊 | NUCLEIC ACIDS RESEARCH |
ISSN | 0305-1048 |
卷号 | 49期号:7页码:3764-3780 |
摘要 | Molecular bases of eukaryotic circadian clocks mainly rely on transcriptional-translational feedback loops (TTFLs), while epigenetic codes also play critical roles in fine-tuning circadian rhythms. However, unlike histone modification codes that play extensive and well-known roles in the regulation of circadian clocks, whether DNA methylation (5mC) can affect the circadian clock, and the associated underlying molecular mechanisms, remains largely unexplored in many organisms. Here we demonstrate that global genome DNA hypomethylation can significantly lengthen the circadian period of Arabidopsis. Transcriptomic and genetic evidence demonstrate that SUPPRESSOR OF drm1 drm2 cmt3 (SDC), encoding an F-box containing protein, is required for the DNA hypomethylation-tuned circadian clock. Moreover, SDC can physically interact with another F-box containing protein ZEITLUPE (ZTL) to diminish its accumulation. Genetic analysis further revealed that ZTL and its substrate TIMING OF CAB EXPRESSION 1 (TOC1) likely act downstream of DNA methyltransferases to control circadian rhythm. Together, our findings support the notion that DNA methylation is important to maintain proper circadian pace in Arabidopsis, and further established that SDC links DNA hypomethylation with a proteolytic cascade to assist in tuning the circadian clock. |
学科领域 | Biochemistry & Molecular Biology |
DOI | 10.1093/nar/gkab128 |
收录类别 | SCI |
语种 | 英语 |
WOS关键词 | PSEUDO-RESPONSE REGULATORS ; NATURAL ALLELIC VARIATION ; CIRCADIAN CLOCK ; POSTTRANSLATIONAL REGULATION ; TARGETED DEGRADATION ; LEAF SENESCENCE ; COMPLEX ; PLANT ; GROWTH ; TOC1 |
WOS研究方向 | Science Citation Index Expanded (SCI-EXPANDED) |
WOS记录号 | WOS:000649006000019 |
出版者 | OXFORD UNIV PRESS |
文献子类 | Article |
出版地 | OXFORD |
EISSN | 1362-4962 |
资助机构 | Strategic Priority Research Program of the Chinese Academy of Sciences [XDB27030206] ; National Natural Science Foundation of China [31570292] ; Chinese Academy of Sciences [XDB27030206] ; Priority Research Program of the Chinese Academy of Sciences [XDB27030206] |
作者邮箱 | wanglei@ibcas.ac.cn |
作品OA属性 | Green Published, gold |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ibcas.ac.cn/handle/2S10CLM1/26440 |
专题 | 中科院植物分子生理学重点实验室 |
作者单位 | 1.Chinese Acad Sci, CAS Ctr Excellence Mol Plant Sci, Inst Bot, Key Lab Plant Mol Physiol, Beijing 100093, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Gyeongsang Natl Univ, Res Inst Life Sci RILS, Div Appl Life Sci BK21Plus, Jinju 52828, South Korea 4.Gyeongsang Natl Univ, Inst Agr & Life Sci IALS, Jinju 52828, South Korea |
推荐引用方式 GB/T 7714 | Tian, Wenwen,Wang, Ruyi,Bo, Cunpei,et al. SDC mediates DNA methylation-controlled clock pace by interacting with ZTL in Arabidopsis[J]. NUCLEIC ACIDS RESEARCH,2021,49(7):3764-3780. |
APA | Tian, Wenwen.,Wang, Ruyi.,Bo, Cunpei.,Yu, Yingjun.,Zhang, Yuanyuan.,...&Wang, Lei.(2021).SDC mediates DNA methylation-controlled clock pace by interacting with ZTL in Arabidopsis.NUCLEIC ACIDS RESEARCH,49(7),3764-3780. |
MLA | Tian, Wenwen,et al."SDC mediates DNA methylation-controlled clock pace by interacting with ZTL in Arabidopsis".NUCLEIC ACIDS RESEARCH 49.7(2021):3764-3780. |
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Tian-2021-SDC mediat(10974KB) | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 |
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