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Arginine Methyltransferase PeRmtC Regulates Development and Pathogenicity of Penicillium expansum via Mediating Key Genes in Conidiation and Secondary Metabolism
Xu, Xiaodi1; Chen, Yong; Li, Boqiang; Tian, Shiping1
2021
发表期刊JOURNAL OF FUNGI
卷号7期号:10
摘要Penicillium expansum is one of the most common and destructive post-harvest fungal pathogens that can cause blue mold rot and produce mycotoxins in fruit, leading to significant post-harvest loss and food safety concerns. Arginine methylation by protein arginine methyltransferases (PRMTs) modulates various cellular processes in many eukaryotes. However, the functions of PRMTs are largely unknown in post-harvest fungal pathogens. To explore their roles in P. expansum, we identified four PRMTs (PeRmtA, PeRmtB, PeRmtC, and PeRmt2). The single deletion of PeRmtA, PeRmtB, or PeRmt2 had minor or no impact on the P. expansum phenotype while deletion of PeRmtC resulted in decreased conidiation, delayed conidial germination, impaired pathogenicity and pigment biosynthesis, and altered tolerance to environmental stresses. Further research showed that PeRmtC could regulate two core regulatory genes, PeBrlA and PeAbaA, in conidiation, a series of backbone genes in secondary metabolism, and affect the symmetric omega-N-G, N'(G)-dimethylarginine (sDMA) modification of proteins with molecular weights of primarily 16-17 kDa. Collectively, this work functionally characterized four PRMTs in P. expansum and showed the important roles of PeRmtC in the development, pathogenicity, and secondary metabolism of P. expansum.

关键词Penicillium expansum protein arginine methyltransferase development pathogenicity metabolism regulation
学科领域Microbiology ; Mycology
DOI10.3390/jof7100807
收录类别SCI
语种英语
WOS关键词DISTINCT STAGES ; METHYLATION ; EXPRESSION ; PATULIN ; BIOSYNTHESIS ; REVEALS ; CULTURE ; ABAA
WOS研究方向Science Citation Index Expanded (SCI-EXPANDED)
WOS记录号WOS:000713191500001
出版者MDPI
文献子类Article
出版地BASEL
EISSN2309-608X
资助机构National Natural Science Foundation of China [31930086, 32072273, 32002099] ; Youth Innovation Promotion Association CAS [Y201919] ; China Postdoctoral Science Foundation [2020M670523]
作者邮箱xuxiaodi@ibcas.ac.cn ; chenyong@ibcas.ac.cn ; bqli@ibcas.ac.cn ; tsp@ibcas.ac.cn
作品OA属性Green Published, gold
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ibcas.ac.cn/handle/2S10CLM1/26555
专题中科院北方资源植物重点实验室
作者单位1.Chinese Acad Sci, Innovat Acad Seed Design, Inst Bot, Key Lab Plant Resources, Beijing 100093, Peoples R China
2.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China
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Xu, Xiaodi,Chen, Yong,Li, Boqiang,et al. Arginine Methyltransferase PeRmtC Regulates Development and Pathogenicity of Penicillium expansum via Mediating Key Genes in Conidiation and Secondary Metabolism[J]. JOURNAL OF FUNGI,2021,7(10).
APA Xu, Xiaodi,Chen, Yong,Li, Boqiang,&Tian, Shiping.(2021).Arginine Methyltransferase PeRmtC Regulates Development and Pathogenicity of Penicillium expansum via Mediating Key Genes in Conidiation and Secondary Metabolism.JOURNAL OF FUNGI,7(10).
MLA Xu, Xiaodi,et al."Arginine Methyltransferase PeRmtC Regulates Development and Pathogenicity of Penicillium expansum via Mediating Key Genes in Conidiation and Secondary Metabolism".JOURNAL OF FUNGI 7.10(2021).
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