Knowledge Management System Of Institute Of Botany,CAS
| Heavy Metal Contaminations in Herbal Medicines: Determination, Comprehensive Risk Assessments, and Solutions | |
| Luo, Lu; Wang, Bo1; Jiang, Jingwen2; Fitzgerald, Martin3; Huang, Qin; Yu, Zheng4; Li, Hui5; Zhang, Jiqing; Wei, Jianhe6; Yang, Chenyuyan7; Zhang, Hui8; Dong, Linlin; Chen, Shilin | |
| 2021 | |
| 发表期刊 | FRONTIERS IN PHARMACOLOGY
 |
| 卷号 | 11 |
| 摘要 | Heavy metal contamination in herbal medicines is a global threat to human beings especially at levels above known threshold concentrations. The concentrations of five heavy metals cadmium (Cd), lead (Pb), arsenic (As), mercury (Hg) and copper (Cu) were investigated using Inductively Coupled Plasma Optical Mass Spectrometry (ICP-MS) with 1773 samples around the world. According to Chinese Pharmacopoeia, 30.51% (541) samples were detected with at least one over-limit metal. The over-limit ratio for Pb was 5.75% (102), Cd at 4.96% (88), As at 4.17% (74), Hg at 3.78% (67), and of Cu, 1.75% (31). For exposure assessment, Pb, Cd, As, and Hg have resulted in higher than acceptable risks in 25 kinds of herbs. The maximal Estimated Daily Intake of Pb in seven herbs, of Cd in five, of Hg in four, and As in three exceeded their corresponding Provisional Tolerable Daily Intakes. In total 25 kinds of herbs present an unacceptable risk as assessed with the Hazard Quotient or Hazard Index. Additionally, the carcinogenic risks were all under acceptable limits. Notably, As posed the highest risk in all indicators including Estimated Daily Intake, Hazard Index, and carcinogenic risks. Therefore further study on enrichment effect of different states of As and special attention to monitoring shall be placed on As related contamination. |
| 关键词 | heavy metal risk assessment safety and quality herbal mecidine extrinsic contamination |
| 学科领域 | Pharmacology & Pharmacy |
| DOI | 10.3389/fphar.2020.595335 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS关键词 | ICP-MS ; PLANTS ; HAZARDS ; SOILS |
| WOS研究方向 | Science Citation Index Expanded (SCI-EXPANDED) |
| WOS记录号 | WOS:000612207900001 |
| 出版者 | FRONTIERS MEDIA SA |
| 文献子类 | Article |
| 出版地 | LAUSANNE |
| EISSN | 1663-9812 |
| 资助机构 | Beijing Nova Program [Z181100006218020] ; Fundamental Research Funds for the central public welfare research institutes [ZZ13-AQ-049] ; Major science and technology projects of Yunnan province [2018ZF011] ; National Key RD Plan [2018YFC1706302] ; National Science and Technology Major Project for Significant New Drugs Development [2019ZX09201005-006001] ; National Natural Science Foundation [81973429] |
| 作者邮箱 | lldong@icmm.ac.cn ; slchen@icmm.ac.cn |
| 作品OA属性 | Green Submitted, gold, Green Published |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ibcas.ac.cn/handle/2S10CLM1/26614 |
| 专题 | 中科院北方资源植物重点实验室 |
| 作者单位 | 1.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing, Peoples R China 2.Hubei Inst Drug Control, Wuhan, Peoples R China 3.Sichuan Univ, West China Hosp, West China Biomed Big Data Ctr, Chengdu, Peoples R China 4.Univ Westminster, Dept Life Sci, London, England 5.Chengdu Univ Tradit Chinese Med, Coll Med Informat & Engn, Chengdu, Peoples R China 6.Chinese Acad Sci, Inst Bot, Beijing, Peoples R China 7.Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Hainan Branch, Hainan Prov Key Lab Resources Conservat & Dev Sou, Haikou, Hainan, Peoples R China 8.Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Informat, Beijing, Peoples R China 9.Akupunktur Akad, Hovedgaard, Denmark |
| 推荐引用方式 GB/T 7714 | Luo, Lu,Wang, Bo,Jiang, Jingwen,et al. Heavy Metal Contaminations in Herbal Medicines: Determination, Comprehensive Risk Assessments, and Solutions[J]. FRONTIERS IN PHARMACOLOGY,2021,11. |
| APA | Luo, Lu.,Wang, Bo.,Jiang, Jingwen.,Fitzgerald, Martin.,Huang, Qin.,...&Chen, Shilin.(2021).Heavy Metal Contaminations in Herbal Medicines: Determination, Comprehensive Risk Assessments, and Solutions.FRONTIERS IN PHARMACOLOGY,11. |
| MLA | Luo, Lu,et al."Heavy Metal Contaminations in Herbal Medicines: Determination, Comprehensive Risk Assessments, and Solutions".FRONTIERS IN PHARMACOLOGY 11(2021). |
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| S16639812_S166398122（2462KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
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