Callicarpa japonica Thunb. ameliorates allergic airway inflammation by suppressing NF-kappa B activation and upregulating HO-1 expression

doi:10.1016/j.jep.2020.113523

	Callicarpa japonica Thunb. ameliorates allergic airway inflammation by suppressing NF-kappa B activation and upregulating HO-1 expression
	Kim, Seong-Man ; Ryu, Hyung Won ; Kwon, Ok-Kyoung ; Hwang, Daseul ; Kim, Min Gu ; Min, Jae-Hong ; Zhang, Zhiyun 3; Kim, Soo-Yong ; Paik, Jin-Hyub ; Oh, Sei-Ryang ; Ahn, Kyung-Seop ; Lee, Jae-Won
	2021
发表期刊	JOURNAL OF ETHNOPHARMACOLOGY
ISSN	0378-8741
卷号	267
摘要	Ethnopharmacological relevance: Callicarpa japonica Thunb., as an herbal medicine has been used for the treatment of inflammatory diseases in China and Korea. Materials and methods: Ultra performance liquid chromatography-photodiode array-quadrupole time-of-flight mass spectrometer (UPLC-PDA-QTof MS) was used to detect the major phenylethanoid glycosides in the C. japonica extract. BALB/c mice were intraperitoneally sensitized by ovalbumin (OVA) (on days 0 and 7) and challenged by OVA aerosol (on days 11-13) to induce airway inflammatory response. The mice were also administered with C. japonica Thunb. (CJT) (20 and 40 mg/kg Per oral) on days 9-13. CJT pretreatment was conducted in lipopolysaccharide (LPS)-stimulated RAW264.7 or phorbol 12-myristate 13-acetate (PMA)-stimulated A549 cells. Results: CJT administration significantly reduced the secretion of Th2 cytokines, TNF-alpha, IL-6, immunoglobulin E (IgE) and histamine, and the recruitment of eosinophils in an OVA-exposed mice. In histological analyses, the amelioration of inflammatory cell influx and mucus secretion were observed with CJT. The OVA-induced airway hyperresponsiveness (AHR), iNOS expression and NF-kappa B activation were effectively suppressed by CJT administration. In addition, CJT led to the upregulation of HO-1 expression. In an in vitro study, CJT pretreatment suppressed the LPS-induced TNF-alpha secretion in RAW264.7 cells and attenuated the PMA-induced IL-6, IL-8 and MCP-1 secretion in A549 cells. These effects were accompanied by downregulated NF-kappa B phosphorylation and by upregulated HO-1 expression. Conclusion: These results suggested that CJT has protective activity against OVA-induced airway inflammation via downregulation of NF-kappa B activation and upregulation of HO-1, suggesting that CJT has preventive potential for the development of allergic asthma.
关键词	Allergic asthma Callicarpa japonica Thunb. Th2 cytokines Eosinophil NF-kappa B HO-1
学科领域	Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
DOI	10.1016/j.jep.2020.113523
收录类别	SCI
语种	英语
WOS关键词	BRONCHIAL HYPERRESPONSIVENESS ; INDUCED ASTHMA ; TH2 CYTOKINES ; RESPONSES ; EXTRACT ; ALPHA ; MODEL ; CORTICOSTEROIDS ; INTERLEUKIN-6 ; PATHWAY
WOS研究方向	Science Citation Index Expanded (SCI-EXPANDED)
WOS记录号	WOS:000606369500003
出版者	ELSEVIER IRELAND LTD
文献子类	Article
出版地	CLARE
EISSN	1872-7573
资助机构	Korea Research Institute of Bioscience and Biotechnology Research Initiative Program [KGM 5522012] ; Ministry of Health and Welfare of Republic of Korea [HI14C1277]
作者邮箱	ksm2906@kribb.re.kr ; ryuhw@kribb.re.kr ; dooli@kribb.re.kr ; seul3104@kribb.re.kr ; alsrn0520@kribb.re.kr ; 01020835969@kribb.re.kr ; zhangzy@ibcas.ac.cn ; soodole@kribb.re.kr ; jpaik@kribb.re.kr ; seiryang@kribb.re.kr ; ksahn@kribb.re.kr ; suc369@kribb.re.kr
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/26622
专题	系统与进化植物学国家重点实验室
作者单位	1.Korea Res Inst Biosci & Biotechnol KRIBB, Nat Med Res Ctr, Chungbuk 28116, South Korea 2.Chungnam Natl Univ, Coll Pharm, 99 Daehak Ro, Daejeon 305764, South Korea 3.Chungbuk Natl Univ, Coll Pharm, Cheongju 28160, Chungcheongbuk, South Korea 4.Chinese Acad Sci, Inst Bot, State Key Lab Systemat & Evolutionary Bot, Beijing 100093, Peoples R China 5.Korea Res Inst Biosci & Biotechnol, Int Biol Mat Res Ctr, 125 Gwahak Ro, Daejeon 34141, Peoples R China
推荐引用方式 GB/T 7714	Kim, Seong-Man,Ryu, Hyung Won,Kwon, Ok-Kyoung,et al. Callicarpa japonica Thunb. ameliorates allergic airway inflammation by suppressing NF-kappa B activation and upregulating HO-1 expression[J]. JOURNAL OF ETHNOPHARMACOLOGY,2021,267.
APA	Kim, Seong-Man.,Ryu, Hyung Won.,Kwon, Ok-Kyoung.,Hwang, Daseul.,Kim, Min Gu.,...&Lee, Jae-Won.(2021).Callicarpa japonica Thunb. ameliorates allergic airway inflammation by suppressing NF-kappa B activation and upregulating HO-1 expression.JOURNAL OF ETHNOPHARMACOLOGY,267.
MLA	Kim, Seong-Man,et al."Callicarpa japonica Thunb. ameliorates allergic airway inflammation by suppressing NF-kappa B activation and upregulating HO-1 expression".JOURNAL OF ETHNOPHARMACOLOGY 267(2021).

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