The Chloroplast Epitranscriptome: Factors, Sites, Regulation, and Detection Methods

doi:10.3390/genes12081121

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	The Chloroplast Epitranscriptome: Factors, Sites, Regulation, and Detection Methods
	Manavski, Nikolay ; Vicente, Alexandre ; Chi, Wei 1; Meurer, Jorg
	2021
发表期刊	GENES
卷号	12 期号:8
摘要	Modifications in nucleic acids are present in all three domains of life. More than 170 distinct chemical modifications have been reported in cellular RNAs to date. Collectively termed as epitranscriptome, these RNA modifications are often dynamic and involve distinct regulatory proteins that install, remove, and interpret these marks in a site-specific manner. Covalent nucleotide modifications-such as methylations at diverse positions in the bases, polyuridylation, and pseudouridylation and many others impact various events in the lifecycle of an RNA such as folding, localization, processing, stability, ribosome assembly, and translational processes and are thus crucial regulators of the RNA metabolism. In plants, the nuclear/cytoplasmic epitranscriptome plays important roles in a wide range of biological processes, such as organ development, viral infection, and physiological means. Notably, recent transcriptome-wide analyses have also revealed novel dynamic modifications not only in plant nuclear/cytoplasmic RNAs related to photosynthesis but especially in chloroplast mRNAs, suggesting important and hitherto undefined regulatory steps in plastid functions and gene expression. Here we report on the latest findings of known plastid RNA modifications and highlight their relevance for the post-transcriptional regulation of chloroplast gene expression and their role in controlling plant development, stress reactions, and acclimation processes.
关键词	chloroplast RNA metabolism epitranscriptome RNA methylation posttranscriptional regulation development acclimation stress response
学科领域	Genetics & Heredity
DOI	10.3390/genes12081121
收录类别	SCI
语种	英语
WOS关键词	PENTATRICOPEPTIDE REPEAT PROTEIN ; TRANSFER-RNA MODIFICATION ; 25S RIBOSOMAL-RNA ; MESSENGER-RNA ; NUCLEOTIDE-SEQUENCE ; ESCHERICHIA-COLI ; ARABIDOPSIS ; POLYADENYLATION ; METHYLATION ; GENE
WOS研究方向	Science Citation Index Expanded (SCI-EXPANDED)
WOS记录号	WOS:000689207400001
出版者	MDPI
文献子类	Review
出版地	BASEL
EISSN	2073-4425
资助机构	DAAD [91692277] ; DFG [TR175]
作者邮箱	n.manavski@biologie.uni-muenchen.de ; a.vicente@campus.lmu.de ; chiweimr@ibcas.ac.cn ; meurer@bio.lmu.de
作品OA属性	Green Published
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/26676
专题	中科院光生物学重点实验室
作者单位	1.Ludwig Maximilians Univ Munchen, Plant Mol Biol, Fac Biol, Grosshaderner St 2-4, D-82152 Planegg, Germany 2.Chinese Acad Sci, Inst Bot, Photosynth Res Ctr, Key Lab Photobiol, Beijing 100093, Peoples R China
推荐引用方式 GB/T 7714	Manavski, Nikolay,Vicente, Alexandre,Chi, Wei,et al. The Chloroplast Epitranscriptome: Factors, Sites, Regulation, and Detection Methods[J]. GENES,2021,12(8).
APA	Manavski, Nikolay,Vicente, Alexandre,Chi, Wei,&Meurer, Jorg.(2021).The Chloroplast Epitranscriptome: Factors, Sites, Regulation, and Detection Methods.GENES,12(8).
MLA	Manavski, Nikolay,et al."The Chloroplast Epitranscriptome: Factors, Sites, Regulation, and Detection Methods".GENES 12.8(2021).

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