Mapping causal genes and genetic interactions for agronomic traits using a large F-2 population in rice

doi:10.1093/g3journal/jkab318

	Mapping causal genes and genetic interactions for agronomic traits using a large F-2 population in rice
	Feng, Laibao 1,2; Ma, Aimin 2; Song, Bo 2; Yu, Sibin 3; Qi, Xiaoquan2
	2021
发表期刊	G3-GENES GENOMES GENETICS
ISSN	2160-1836
卷号	11 期号:11
摘要	Dissecting the genetic mechanisms underlying agronomic traits is of great importance for crop breeding. Agronomic traits are usually controlled by multiple quantitative trait loci (QTLs) and genetic interactions, and mapping the underlying causal genes is still labor-intensive and time-consuming. Here, we present a genetic tool for directly targeting the specific causal genes by using a single-gene resolution linkage map that was constructed from 3756 F-2 rice plants via targeted sequencing technology and Tukey-Kramer multiple comparisons test. Three large- and moderate-effect QTLs, qHD6-2, qGL3-1, and qGW5-2, were successfully mapped to their specific causal genes, Hd1, GS3, and GW5, respectively. A complex genetic interaction network containing 30 QTL-QTL interactions was constructed, revealing that the alternative allele of hub QTL, qHD6-2, can hide or release the genetic contributions of the alleles at interacting loci. Moreover, arranging genetic interactions in the models lead to more accurate phenotypic predictions. These results provide a community resource and new feasible strategy for deciphering the genetic mechanisms of complex agronomic traits and accelerating crop breeding.
关键词	quantitative trait loci large F-2 population rice causal gene genetic interactions
学科领域	Genetics & Heredity
DOI	10.1093/g3journal/jkab318
收录类别	SCI
语种	英语
WOS关键词	GENOME-WIDE ASSOCIATION ; NATURAL VARIATION ; READ ALIGNMENT ; FLOWERING TIME ; GRAIN LENGTH ; REVEALS ; HETEROSIS ; PROTEIN ; IDENTIFICATION ; EPISTASIS
WOS研究方向	Science Citation Index Expanded (SCI-EXPANDED)
WOS记录号	WOS:000735905700043
出版者	OXFORD UNIV PRESS INC
文献子类	Article
出版地	CARY
资助机构	National Transgenic Megaproject of China [2016ZX08009001-006] ; Strategic Priority Research Program of the Chinese Academy of Sciences [XDB27010202] ; Nation Key Research and Development Program of China [2016YFD0100904]
作者邮箱	xqi@ibcas.ac.cn
作品OA属性	Green Published, gold
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/26739
专题	中科院植物分子生理学重点实验室
作者单位	1.Chinese Acad Sci, Inst Bot, Key Lab Plant Mol Physiol, Beijing 100093, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Innovat Acad Seed Design, Beijing 100049, Peoples R China 4.Huazhong Agr Univ, Coll Plant Sci & Technol, Natl Key Lab Crop Genet Improvement, Wuhan 430070, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Feng, Laibao,Ma, Aimin,Song, Bo,et al. Mapping causal genes and genetic interactions for agronomic traits using a large F-2 population in rice[J]. G3-GENES GENOMES GENETICS,2021,11(11).
APA	Feng, Laibao,Ma, Aimin,Song, Bo,Yu, Sibin,&Qi, Xiaoquan.(2021).Mapping causal genes and genetic interactions for agronomic traits using a large F-2 population in rice.G3-GENES GENOMES GENETICS,11(11).
MLA	Feng, Laibao,et al."Mapping causal genes and genetic interactions for agronomic traits using a large F-2 population in rice".G3-GENES GENOMES GENETICS 11.11(2021).

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