Biosynthesis, regulation, and domestication of bitterness in cucumber

doi:10.1126/science.1259215

	Biosynthesis, regulation, and domestication of bitterness in cucumber
	Shang, Yi 1; Ma, Yongshuo 2; Zhou, Yuan 3; Zhang, Huimin 2; Duan, Lixin 4; Chen, Huiming 5; Zeng, Jianguo 3; Zhou, Qian ; Wang, Shenhao ; Gu, Wenjia 6; Liu, Min 2; Ren, Jinwei 7; Gu, Xingfang ; Zhang, Shengping ; Wang, Ye ; Yasukawa, Ken 8; Bouwmeester, Harro J.; Qi, Xiaoquan4 ; Zhang, Zhonghua ; Lucas, William J.; Huang, Sanwen 1
	2014
发表期刊	SCIENCE
ISSN	0036-8075
卷号	346 期号:6213 页码:1084-1088
摘要	Cucurbitacins are triterpenoids that confer a bitter taste in cucurbits such as cucumber, melon, watermelon, squash, and pumpkin. These compounds discourage most pests on the plant and have also been shown to have antitumor properties. With genomics and biochemistry, we identified nine cucumber genes in the pathway for biosynthesis of cucurbitacin C and elucidated four catalytic steps. We discovered transcription factors Bl (Bitter leaf) and Bt (Bitter fruit) that regulate this pathway in leaves and fruits, respectively. Traces in genomic signatures indicated that selection imposed on Bt during domestication led to derivation of nonbitter cucurbits from their bitter ancestors.
学科领域	Multidisciplinary Sciences
DOI	10.1126/science.1259215
收录类别	SCI
语种	英语
WOS关键词	SPECIALIZED METABOLISM ; BIOLOGICAL-ACTIVITIES ; CUCURBITACIN-C ; CANCER-CELLS ; SATIVUS L ; PLANTS ; GENE ; RESISTANCE ; PATHWAY
WOS研究方向	Science & Technology - Other Topics
WOS记录号	WOS:000345763400035
出版者	AMER ASSOC ADVANCEMENT SCIENCE
文献子类	Article
出版地	WASHINGTON
EISSN	1095-9203
资助机构	Spanish Consolider-Ingenio program [CPAN CSD2007-00042, MultiDark CSD2009-00064] ; Academy of Finland [127740] ; DFG Cluster of Excellence ; Croatian Science Foundation (HrZZ) [09/176] ; University of Rijeka [13.12.1.3.02] ; DFG Collaborative Research Centers [SFB823/C4, SFB876/C3] ; Polish MNiSzW grant [745/N-HESS-MAGIC/2010/0] ; DFG [WI 1860/10-1] ; ERDF ; Spanish MINECO [FPA2012-39502, JCI-2011-10019, AYA2009-13036-C02-02, AYA2012-38491-C02-01] ; Generalitat Valenciana [PROMETEO/2009/104] ; COST [MP0905] ; national research councils ; European Commission [283393]
作者邮箱	huangsanwen@caas.cn
引用统计	被引频次：309[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/27044
专题	中科院植物分子生理学重点实验室
作者单位	1.Chinese Acad Agr Sci, Key Lab Biol & Genet Improvement Hort Crops, Sinodutch Joint Lab Hort Genom, Inst Vegetables & Flowers,Minist Agr, Beijing 100081, Peoples R China 2.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Shenzhen 518124, Peoples R China 3.Nanjing Agr Univ, Coll Life Sci, Nanjing 210095, Jiangsu, Peoples R China 4.Hunan Agr Univ, Hort & Landscape Coll, Natl Chinese Med Herbs Technol Ctr, Changsha 410128, Hunan, Peoples R China 5.Chinese Acad Sci, Inst Bot, Beijing 100093, Peoples R China 6.Hunan Acad Agr Sci, Hunan Vegetable Res Inst, Changsha 410125, Hunan, Peoples R China 7.Wuhan Univ, Coll Life Sci, Wuhan 430072, Peoples R China 8.Chinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R China 9.Nihon Univ, Sch Pharm, Tokyo 1018308, Japan 10.Bouwmeester, Harro J.] Wageningen Univ, Lab Plant Physiol, NL-6700 Wageningen, Netherlands 11.Lucas, William J.] Univ Calif Davis, Coll Biol Sci, Dept Plant Biol, Davis, CA 95616 USA
推荐引用方式 GB/T 7714	Shang, Yi,Ma, Yongshuo,Zhou, Yuan,et al. Biosynthesis, regulation, and domestication of bitterness in cucumber[J]. SCIENCE,2014,346(6213):1084-1088.
APA	Shang, Yi.,Ma, Yongshuo.,Zhou, Yuan.,Zhang, Huimin.,Duan, Lixin.,...&Huang, Sanwen.(2014).Biosynthesis, regulation, and domestication of bitterness in cucumber.SCIENCE,346(6213),1084-1088.
MLA	Shang, Yi,et al."Biosynthesis, regulation, and domestication of bitterness in cucumber".SCIENCE 346.6213(2014):1084-1088.

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