Requirement for A-type cyclin-dependent kinase and cyclins for the terminal division in the stomatal lineage of Arabidopsis

doi:10.1093/jxb/eru139

	Requirement for A-type cyclin-dependent kinase and cyclins for the terminal division in the stomatal lineage of Arabidopsis
	Yang, Kezhen; Wang, Hongzhe; Xue, Shan; Qu, Xiaoxiao; Zou, Junjie; Le, Jie
	2014
发表期刊	JOURNAL OF EXPERIMENTAL BOTANY
ISSN	0022-0957
卷号	65 期号:9 页码:2449-2461
摘要	The Arabidopsis stoma is a specialized epidermal valve made up of a pair of guard cells around a pore whose aperture controls gas exchange between the shoot and atmosphere. Guard cells (GCs) are produced by a symmetric division of guard mother cells (GMCs). The R2R3-MYB transcription factor FOUR LIPS (FLP) and its paralogue MYB88 restrict the division of a GMC to one. Previously, the upstream regions of several core cell cycle genes were identified as the direct targets of FLP/MYB88, including the B-type cyclin-dependent kinase CDKB1;1 and A2-type cyclin CYCA2;3. Here we show that CDKA;1 is also an immediate direct target of FLP/MYB88 through the binding to cis-regulatory elements in the CDKA;1 promoter region. CDKA;1 activity is required not only for normal GMC divisions but also for the excessive cell overproliferation in flp myb88 mutant GMCs. The impaired defects of GMC division in cdkb1;1 1;2 mutants could be partially rescued by a stage-specific expression of CDKA;1. Although targeted overexpression of CDKA;1 does not affect stomatal development, ectopic expression of the D3-type cyclin CYCD3;2 induces GC subdivision, resulting in a stoma with 3-4 GCs instead of the normal two. Co-overexpression of CDKA;1 with CYCD3;2, but not with CYCA2;3, confers a synergistic effect with respect to GC subdivision. Thus, in addition to a role in stomatal formative asymmetric divisions at early developmental stages, CDKA;1 is needed in triggering GMC symmetric divisions at the late stage of stomatal development. However, timely down-regulation of CDKA;1-CYCD3 activity is required for restriction of GC proliferation.
关键词	Arabidopsis cell cycle stomatal development symmetric division transcription factor
学科领域	Plant Sciences
DOI	10.1093/jxb/eru139
收录类别	SCI
语种	英语
WOS关键词	ASYMMETRIC CELL DIVISIONS ; PLANT DEVELOPMENT ; 4 LIPS ; PROLIFERATION ; ENDOREDUPLICATION ; DIFFERENTIATION ; EXPRESSION ; GENES ; PERSPECTIVE ; TRANSITION
WOS研究方向	Plant Sciences
WOS记录号	WOS:000337978800018
出版者	OXFORD UNIV PRESS
文献子类	Article
出版地	OXFORD
EISSN	1460-2431
资助机构	National Natural Science Foundation of China [30971652, 31271463, 31071198] ; Chinese Academy of Sciences [KSCX2-YW-N-073]
作者邮箱	lejie@ibcas.ac.cn
作品OA属性	Green Submitted, Green Published, hybrid
引用统计	被引频次：38[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/27141
专题	中科院植物分子生理学重点实验室
作者单位	Chinese Acad Sci, Inst Bot, Key Lab Plant Mol Physiol, Beijing 100093, Peoples R China
推荐引用方式 GB/T 7714	Yang, Kezhen,Wang, Hongzhe,Xue, Shan,et al. Requirement for A-type cyclin-dependent kinase and cyclins for the terminal division in the stomatal lineage of Arabidopsis[J]. JOURNAL OF EXPERIMENTAL BOTANY,2014,65(9):2449-2461.
APA	Yang, Kezhen,Wang, Hongzhe,Xue, Shan,Qu, Xiaoxiao,Zou, Junjie,&Le, Jie.(2014).Requirement for A-type cyclin-dependent kinase and cyclins for the terminal division in the stomatal lineage of Arabidopsis.JOURNAL OF EXPERIMENTAL BOTANY,65(9),2449-2461.
MLA	Yang, Kezhen,et al."Requirement for A-type cyclin-dependent kinase and cyclins for the terminal division in the stomatal lineage of Arabidopsis".JOURNAL OF EXPERIMENTAL BOTANY 65.9(2014):2449-2461.

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