Human coding RNA editing is generally nonadaptive

doi:10.1073/pnas.1321745111

	Human coding RNA editing is generally nonadaptive
	Xu, Guixia1 ; Zhang, Jianzhi 1
	2014
发表期刊	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN	0027-8424
卷号	111 期号:10 页码:3769-3774
摘要	Impairment of RNA editing at a handful of coding sites causes severe disorders, prompting the view that coding RNA editing is highly advantageous. Recent genomic studies have expanded the list of human coding RNA editing sites by more than 100 times, raising the question of how common advantageous RNA editing is. Analyzing 1,783 human coding A-to-G editing sites, we show that both the frequency and level of RNA editing decrease as the importance of a site or gene increases; that during evolution, edited As are more likely than unedited As to be replaced with Gs but not with Ts or Cs; and that among nonsynonymously edited As, those that are evolutionarily least conserved exhibit the highest editing levels. These and other observations reveal the overall nonadaptive nature of coding RNA editing, despite the presence of a few sites in which editing is clearly beneficial. We propose that most observed coding RNA editing results from tolerable promiscuous targeting by RNA editing enzymes, the original physiological functions of which remain elusive.
关键词	deleterious neutral synonymous
学科领域	Multidisciplinary Sciences
DOI	10.1073/pnas.1321745111
收录类别	SCI
语种	英语
WOS关键词	DNA-SEQUENCE DIFFERENCES ; HIGHLY EXPRESSED PROTEINS ; HUMAN TRANSCRIPTOME ; WIDESPREAD RNA ; SEQ DATA ; GLUR-B ; GENES ; EVOLUTION ; SITES ; IDENTIFICATION
WOS研究方向	Science & Technology - Other Topics
WOS记录号	WOS:000332564800038
出版者	NATL ACAD SCIENCES
文献子类	Article
出版地	WASHINGTON
资助机构	National Institutes of Health [R01GM103232] ; National Natural Science Foundation of China [31100170] ; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM103232] Funding Source: NIH RePORTER
作者邮箱	jianzhi@umich.edu
作品OA属性	Green Published
引用统计	被引频次：94[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/27192
专题	系统与进化植物学国家重点实验室
作者单位	1.Chinese Acad Sci, Inst Bot, State Key Lab Systemat & Evolutionary Bot, Beijing 100093, Peoples R China 2.Univ Michigan, Dept Ecol & Evolutionary Biol, Ann Arbor, MI 48109 USA
推荐引用方式 GB/T 7714	Xu, Guixia,Zhang, Jianzhi. Human coding RNA editing is generally nonadaptive[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2014,111(10):3769-3774.
APA	Xu, Guixia,&Zhang, Jianzhi.(2014).Human coding RNA editing is generally nonadaptive.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,111(10),3769-3774.
MLA	Xu, Guixia,et al."Human coding RNA editing is generally nonadaptive".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111.10(2014):3769-3774.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
24567376.pdf（1055KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览请求全文