Comparison of hypoglycemic and antioxidative effects of polysaccharides from four different Dendrobium species

doi:10.1016/j.ijbiomac.2013.12.024

	Comparison of hypoglycemic and antioxidative effects of polysaccharides from four different Dendrobium species
	Pan, Li-Hua ; Li, Xiu-Fang ; Wang, Mei-Na ; Zha, Xue-Qiang ; Yang, Xue-Fei ; Liu, Zhong-Jian ; Luo, Yi-Bo; Luo, Jian-Ping
	2014
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN	0141-8130
卷号	64 页码:420-427
摘要	Four polysaccharides from Dendrobium huoshanense (DHP), D. officinale (DOP), D. nobile (DNP) and D. chrysotoxum (DCP), which had obvious differences in intrinsic viscosities and monosaccharide compositions, were extracted to compare their hypoglycemic and antioxidative activities in alloxan-induced diabetic mice by oral administration. The analysis of fasting blood glucose, glycosylated serum protein and serum insulin levels showed that DHP, DOP and DNP, but not DCP, possessed significant hypoglycemic effect with the decreasing order of DHP > DNP > DOP. Histopathological observation confirmed the capability of DHP, DOP and DNP to intervene the damage in pancreas tissues. The determination of superoxide dismutase, catalase, malonaldehyde and t-glutathione levels in the liver and kidney displayed that DHP, DOP and DNP had protective effects against alloxan-induced oxidative damage and the effect of DHP ranked first. These results suggested that there were significant differences in hypoglycemic and antioxidative activities between four Dendrobium polysaccharides, which may be contributed to their physicochemical properties. (C) 2013 Elsevier B.V. All rights reserved.
关键词	Dendrobium polysaccharides Hypoglycemic activity Antioxidative activity
学科领域	Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
DOI	10.1016/j.ijbiomac.2013.12.024
收录类别	SCI
语种	英语
WOS关键词	ANTI-HYPERGLYCEMIC ACTIVITY ; OXIDATIVE STRESS ; NOBILE LINDL ; PECTIC POLYSACCHARIDE ; STRUCTURAL-ANALYSIS ; STEMS ; MICE ; COMPLICATIONS ; HUOSHANENSE ; MECHANISM
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS记录号	WOS:000334147300062
出版者	ELSEVIER SCIENCE BV
文献子类	Article
出版地	AMSTERDAM
EISSN	1879-0003
资助机构	National Natural Science Foundation of China [20872024, 21006019] ; Key Science and Technology Program of Anhui Province [12010402088] ; Development Funds for Emerging Industries of Strategic Importance of Shenzhen Municipality [CXZZ 20120830103025851]
作者邮箱	liuzj@sinicaorchid.org ; jianpingluo@hfut.edu.cn
引用统计	被引频次：153[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/27210
专题	系统与进化植物学国家重点实验室
作者单位	1.[Pan, Li-Hua 2.Li, Xiu-Fang 3.Zha, Xue-Qiang 4.Yang, Xue-Fei 5.Hefei Univ Technol, Sch Biotechnol & Food Engn, Hefei 230009, Peoples R China 6.[Wang, Mei-Na 7.Orchid Conservat & Res Ctr Shenzhen, Natl Orchid Conservat Ctr China, Shenzhen 518114, Peoples R China 8.Chinese Acad Sci, Inst Bot, State Key Lab Systemat & Evolutionary Bot, Beijing 100093, Peoples R China
推荐引用方式 GB/T 7714	Pan, Li-Hua,Li, Xiu-Fang,Wang, Mei-Na,et al. Comparison of hypoglycemic and antioxidative effects of polysaccharides from four different Dendrobium species[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2014,64:420-427.
APA	Pan, Li-Hua.,Li, Xiu-Fang.,Wang, Mei-Na.,Zha, Xue-Qiang.,Yang, Xue-Fei.,...&Luo, Jian-Ping.(2014).Comparison of hypoglycemic and antioxidative effects of polysaccharides from four different Dendrobium species.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,64,420-427.
MLA	Pan, Li-Hua,et al."Comparison of hypoglycemic and antioxidative effects of polysaccharides from four different Dendrobium species".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 64(2014):420-427.

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