Recent advances and safety issues of transgenic plant-derived vaccines

doi:10.1007/s00253-012-4566-2

	Recent advances and safety issues of transgenic plant-derived vaccines
	Guan, Zheng-jun ; Guo, Bin ; Huo, Yan-lin ; Guan, Zheng-ping ; Dai, Jia-kun ; Wei, Ya-hui
	2013
发表期刊	APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
ISSN	0175-7598
卷号	97 期号:7 页码:2817-2840
摘要	Transgenic plant-derived vaccines comprise a new type of bioreactor that combines plant genetic engineering technology with an organism's immunological response. This combination can be considered as a bioreactor that is produced by introducing foreign genes into plants that elicit special immunogenicity when introduced into animals or human beings. In comparison with traditional vaccines, plant vaccines have some significant advantages, such as low cost, greater safety, and greater effectiveness. In a number of recent studies, antigen-specific proteins have been successfully expressed in various plant tissues and have even been tested in animals and human beings. Therefore, edible vaccines of transgenic plants have a bright future. This review begins with a discussion of the immune mechanism and expression systems for transgenic plant vaccines. Then, current advances in different transgenic plant vaccines will be analyzed, including vaccines against pathogenic viruses, bacteria, and eukaryotic parasites. In view of the low expression levels for antigens in plants, high-level expression strategies of foreign protein in transgenic plants are recommended. Finally, the existing safety problems in transgenic plant vaccines were put forward will be discussed along with a number of appropriate solutions that will hopefully lead to future clinical application of edible plant vaccines.
关键词	Transgenic Plant Vaccine Safety
学科领域	Biotechnology & Applied Microbiology
DOI	10.1007/s00253-012-4566-2
收录类别	SCI
语种	英语
WOS关键词	TOXIN-B-SUBUNIT ; HEAT-LABILE ENTEROTOXIN ; MOUTH-DISEASE VIRUS ; EPIDEMIC DIARRHEA VIRUS ; TRANSMISSIBLE GASTROENTERITIS VIRUS ; SYNTHETIC NEUTRALIZING EPITOPE ; PROTECTIVE ANTIBODY-RESPONSE ; STRUCTURAL PROTEIN VP1 ; INSULIN FUSION PROTEIN ; HIGH-LEVEL EXPRESSION
WOS研究方向	Science Citation Index Expanded (SCI-EXPANDED)
WOS记录号	WOS:000316481800005
出版者	SPRINGER
文献子类	Review
出版地	NEW YORK
EISSN	1432-0614
资助机构	National Natural ScienceFoundation of China(National Natural Science Foundation of China (NSFC)) ; Opening Foundation of Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University) ; Specialized Foundation of Department of Education of Shaanxi Province, China ; Northwestern university graduate self-innovation project ; Yuncheng University Doctor Scientific research project
作品OA属性	Green Published, Bronze
引用统计	被引频次：29[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/28057
专题	植被与环境变化国家重点实验室
作者单位	1.[Guan, Zheng-jun 2.Guo, Bin 3.NW Univ Xian, Key Lab Resource Biol & Biotechnol Western China, Minist Educ, Sch Life Sci, Xian 710069, Peoples R China 4.Yuncheng Univ, Dept Life Sci, Yuncheng 044000, Shanxi, Peoples R China 5.Chinese Acad Sci, Inst Bot, State Key Lab Vegetat & Environm Change, Beijing 100093, Peoples R China 6.Yuncheng Univ, Ctr Biol & Chem Exiperiment, Yuncheng 044000, Shanxi, Peoples R China 7.Nanjing Agr Univ, Dept Anim Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China 8.Acad Sci, Enzyme Engn Inst Shaanxi, Xian 710600, Shaanxi, Peoples R China
推荐引用方式 GB/T 7714	Guan, Zheng-jun,Guo, Bin,Huo, Yan-lin,et al. Recent advances and safety issues of transgenic plant-derived vaccines[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2013,97(7):2817-2840.
APA	Guan, Zheng-jun,Guo, Bin,Huo, Yan-lin,Guan, Zheng-ping,Dai, Jia-kun,&Wei, Ya-hui.(2013).Recent advances and safety issues of transgenic plant-derived vaccines.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,97(7),2817-2840.
MLA	Guan, Zheng-jun,et al."Recent advances and safety issues of transgenic plant-derived vaccines".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 97.7(2013):2817-2840.

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