Control of stem cell homeostasis via interlocking microRNA and microProtein feedback loops

doi:10.1016/j.mod.2012.06.007

	Control of stem cell homeostasis via interlocking microRNA and microProtein feedback loops
	Brandt, Ronny ; Xie, Yakun ; Musielak, Thomas ; Graeff, Moritz ; Stierhof, York-Dieter ; Huang, Hai 1; Liu, Chun-Ming; Wenkel, Stephan
	2013
发表期刊	MECHANISMS OF DEVELOPMENT
ISSN	0925-4773
卷号	130 期号:1 页码:25-33
摘要	Stem cells in the shoot apex of plants produce cells required for the formation of new leaves. Adult leaves are composed of multiple tissue layers arranged along the dorso-ventral (adaxial/abaxial) axis. Class III homeodomain leucine zipper (HD-ZIPIII) transcription factors play an important role in the set-up of leaf polarity in plants. Loss of HD-ZIPIII function results in strongly misshapen leaves and in severe cases fosters the consumption of the apical stem cells, thus causing a growth arrest in mutant plants. HD-ZIPIII mRNA is under tight control by microRNAs 165/166. In addition to the microRNA-action a second layer of regulation is established by LITTLE ZIPPER (ZPR)-type microProteins, which can interact with HD-ZIPIII proteins, forming attenuated protein complexes. Here we show that REVOLUTA (REV, a member of the HD-ZIPIII family) directly regulates the expression of ARGONAUTE10 (AGO10), ZPR1 and ZPR3. Because AGO10 was shown to dampen microRNA165/6 function, REV establishes a positive feedback loop on its own activity. Since ZPR-type microProteins are known to reduce HD-ZIPIII protein activity, REV concomitantly establishes a negative feedback loop. We propose that the interconnection of these microRNA/microProtein feedback loops regulates polarity set-up and stem cell activity in plants. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
关键词	Shoot apical meristem HD-ZIPIII transcription factors LITTLE ZIPPER AGO10 microRNAs microProteins
学科领域	Developmental Biology
DOI	10.1016/j.mod.2012.06.007
收录类别	SCI
语种	英语
WOS关键词	LEAF POLARITY ; GENE ; WUSCHEL ; FATE ; ESTABLISHMENT ; ARGONAUTE1 ; PHABULOSA ; TARGET ; ZIPPER ; ACTS
WOS研究方向	Science Citation Index Expanded (SCI-EXPANDED)
WOS记录号	WOS:000313699900004
出版者	ELSEVIER
文献子类	Article
出版地	AMSTERDAM
EISSN	1872-6356
资助机构	Deutsche Forschungsgemeinschaft (DFG)(German Research Foundation (DFG)) ; European Union (FP7)(European Commission) ; Robert Bosch Foundation ; Ministry for Agriculture (Bundesanstalt fur Landwirtschaft und Ernahrung
作者邮箱	Graeff, Moritz/AAL-8758-2020 ; 刘, 春明/GLU-4320-2022 ; Liu, Chun-Ming/G-1006-2010 ; Graeff, Moritz/A-6423-2015
作品OA属性	Bronze
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/28070
专题	中科院植物分子生理学重点实验室
作者单位	1.Univ Tubingen, Ctr Plant Mol Biol ZMBP, D-72076 Tubingen, Germany 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Plant Physiol & Ecol, Natl Lab Plant Mol Genet, Shanghai 200032, Peoples R China 3.Chinese Acad Sci, Inst Bot, Key Lab Mol Physiol, Ctr Signal Transduct & Metabol, Beijing 100093, Peoples R China
推荐引用方式 GB/T 7714	Brandt, Ronny,Xie, Yakun,Musielak, Thomas,et al. Control of stem cell homeostasis via interlocking microRNA and microProtein feedback loops[J]. MECHANISMS OF DEVELOPMENT,2013,130(1):25-33.
APA	Brandt, Ronny.,Xie, Yakun.,Musielak, Thomas.,Graeff, Moritz.,Stierhof, York-Dieter.,...&Wenkel, Stephan.(2013).Control of stem cell homeostasis via interlocking microRNA and microProtein feedback loops.MECHANISMS OF DEVELOPMENT,130(1),25-33.
MLA	Brandt, Ronny,et al."Control of stem cell homeostasis via interlocking microRNA and microProtein feedback loops".MECHANISMS OF DEVELOPMENT 130.1(2013):25-33.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
22781836.pdf（979KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览请求全文