MHC II DRB variation and trans-species polymorphism in the golden snub-nosed monkey (Rhinopithecus roxellana)

doi:10.1007/s11434-013-5713-6

	MHC II DRB variation and trans-species polymorphism in the golden snub-nosed monkey (Rhinopithecus roxellana)
	Luo MaoFang 1,2; Pan HuiJuan
	2013
发表期刊	CHINESE SCIENCE BULLETIN
ISSN	1001-6538
卷号	58 期号:18 页码:2119-2127
摘要	Genetic variation is generally believed to be important in studying endangered species' adaptive potential. Early studies assessed genetic diversity using nearly neutral markers, such as microsatellite loci and mitochondrial DNA (mtDNA), which are very informative for phylogenetic and phylogeographic reconstructions. However, the variation at these loci cannot provide direct information on selective processes involving the interaction of individuals with their environment, or on the capability to resist continuously evolving pathogens and parasites. The importance of genetic diversity at informative adaptive markers, such as major histocompatibility complex (MHC) genes, is increasingly being realized, especially in endangered, isolated species. Small population size and isolation make the golden snub-nosed monkey (Rhinopithecus roxellana) particularly susceptible to genetic variation losses through inbreeding and restricted gene flow. In this study, we compared the genetic variation and population structure of microsatellites, mtDNA, and the most relevant adaptive region of the MHC II-DRB genes in the golden snub-nosed monkey. We examined three Chinese R. roxellana populations and found the same variation patterns in all gene regions, with the population from Shennongjia population, Hubei Province, showing the lowest polymorphism among three populations. Genetic drift that outweighed balancing selection and the founder effect in these populations may explain the similar genetic variation pattern found in these neutral and adaptive genes.
关键词	golden snub-nosed monkey major histocompatibility complex microsatellite mitochondrial D-loop
学科领域	Multidisciplinary Sciences
DOI	10.1007/s11434-013-5713-6
收录类别	SCI
语种	英语
WOS关键词	HISTOCOMPATIBILITY COMPLEX VARIATION ; LONG-TERM SURVIVAL ; GENETIC DIVERSITY ; LINKAGE DISEQUILIBRIUM ; PHYLOGENETIC ANALYSIS ; SELECTION ; RECOMBINATION ; POPULATIONS ; EVOLUTION ; ALLELES
WOS研究方向	Science Citation Index Expanded (SCI-EXPANDED)
WOS记录号	WOS:000321629800005
出版者	SCIENCE PRESS
Special Issue	SI
文献子类	Article
出版地	BEIJING
EISSN	1861-9541
资助机构	National Natural Science Foundation of China(National Natural Science Foundation of China (NSFC)) ; Project of Public Benefit ; Beijing Forestry University Young Scientist Fund ; State Forestry Administration of China
作品OA属性	Bronze
引用统计	被引频次：9[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/28098
专题	植被与环境变化国家重点实验室
作者单位	1.Beijing Forestry Univ, Coll Nat Conservat, Beijing 100083, Peoples R China 2.Chinese Acad Sci, Inst Zool, Key Lab Anim Ecol & Conservat Biol, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Inst Bot, Key Lab Vegetat & Environm Change, Beijing 100093, Peoples R China
推荐引用方式 GB/T 7714	Luo MaoFang,Pan HuiJuan. MHC II DRB variation and trans-species polymorphism in the golden snub-nosed monkey (Rhinopithecus roxellana)[J]. CHINESE SCIENCE BULLETIN,2013,58(18):2119-2127.
APA	Luo MaoFang,&Pan HuiJuan.(2013).MHC II DRB variation and trans-species polymorphism in the golden snub-nosed monkey (Rhinopithecus roxellana).CHINESE SCIENCE BULLETIN,58(18),2119-2127.
MLA	Luo MaoFang,et al."MHC II DRB variation and trans-species polymorphism in the golden snub-nosed monkey (Rhinopithecus roxellana)".CHINESE SCIENCE BULLETIN 58.18(2013):2119-2127.

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