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| Jujube metabolome selection determined the edible properties acquired during domestication | |
Zhang, Zhong; Shi, Qianqian; Wang, Bin1; Ma, Aimin2; Wang, Yongkang3; Xue, Qingtun; Shen, Bingqi; Hamaila, Halina; Tang, Tang1; Qi, Xiaoquan2 ; Fernie, Alisdair R.; Luo, Jie5; Li, Xingang
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| 2022 | |
| 发表期刊 | PLANT JOURNAL
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| ISSN | 0960-7412 |
| 卷号 | 109期号:5页码:1116-1133 |
| 摘要 | Plants supply both food and medicinal compounds, which are ascribed to diverse metabolites produced by plants. However, studies on domestication-driven changes in the metabolome and genetic basis of bioactive molecules in perennial fruit trees are generally lacking. Here, we conducted multidimensional analyses revealing a singular domestication event involving the genomic and metabolomic selection of jujube trees (Ziziphus jujuba Mill.). The genomic selection for domesticated genes was highly enriched in metabolic pathways, including carbohydrates and specialized metabolism. Domesticated metabolome profiling indicated that 187 metabolites exhibited significant divergence as a result of directional selection. Malic acid was directly selected during domestication, and the simultaneous selection of specialized metabolites, including triterpenes, consequently lead to edible properties. Cyclopeptide alkaloids (CPAs) were specifically targeted for the divergence between dry and fresh cultivars. We identified 1080 significantly associated loci for 986 metabolites. Among them, 15 triterpenes were directly selected at six major loci, allowing the identification of a homologous cluster containing seven 2,3-oxidosqualene cyclases (OSCs). An OSC gene was found to contribute to the reduction in the content of triterpenes during domestication. The complete pathway for synthesizing ursolic acid was dissected by integration of the metabolome and transcriptome. Additionally, an N-methyltransferase involved in the biosynthesis of CPA and responsible for inter-cultivar content variation was identified. The present study promotes our understanding of the selection process of the global metabolome subsequent to fruit tree domestication and facilitates the genetic manipulation of specialized metabolites to enhance their edible traits. |
| 关键词 | domestication metabolome genome-wide association study specialized metabolites fruit tree jujube |
| 学科领域 | Plant Sciences |
| DOI | 10.1111/tpj.15617 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS关键词 | OXIDOSQUALENE CYCLASES ; TRITERPENE SYNTHASE ; NATURAL VARIATION ; FRUIT ; BIOSYNTHESIS ; GENOME ; EVOLUTION ; CLONING |
| WOS研究方向 | Science Citation Index Expanded (SCI-EXPANDED) |
| WOS记录号 | WOS:000770103400008 |
| 出版者 | WILEY |
| 文献子类 | Article |
| 出版地 | HOBOKEN |
| EISSN | 1365-313X |
| 资助机构 | National Key Research and Development Program of China [2018YFD1000607] ; National Natural Science Foundation of China [32001343, 32171839] ; Industrial System Program of Xinjiang Uygur Autonomous Region [XJCYTX-01-07-2021] ; Shaanxi Province Science and Technology Innovation Project [2021XYF-11] |
| 作者邮箱 | jie.luo@hainu.edu.cn ; xingangle@nwsuaf.edu.cn |
| 作品OA属性 | Bronze |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ibcas.ac.cn/handle/2S10CLM1/28475 |
| 专题 | 中科院植物分子生理学重点实验室 |
| 作者单位 | 1.Northwest A&F Univ, Coll Forestry, Res Ctr Jujube Engn & Technol, Key Comprehens Lab Forestry Shaanxi Prov,State Fo, Yangling 712100, Shaanxi, Peoples R China 2.Wuhan Metware Biotechnol Co Ltd, Wuhan 430070, Peoples R China 3.Chinese Acad Sci, Physiol Inst Bot, Key Lab Plant Mol, Beijing 100093, Peoples R China 4.Shanxi Acad Agr Sci, Pomol Inst, Taigu 030815, Peoples R China 5.Fernie, Alisdair R.] Max Planck Inst Mol Plant Physiol, D-14476 Potsdam, Germany 6.Hainan Univ, Coll Trop Crops, Haikou 572208, Hainan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Zhong,Shi, Qianqian,Wang, Bin,et al. Jujube metabolome selection determined the edible properties acquired during domestication[J]. PLANT JOURNAL,2022,109(5):1116-1133. |
| APA | Zhang, Zhong.,Shi, Qianqian.,Wang, Bin.,Ma, Aimin.,Wang, Yongkang.,...&Li, Xingang.(2022).Jujube metabolome selection determined the edible properties acquired during domestication.PLANT JOURNAL,109(5),1116-1133. |
| MLA | Zhang, Zhong,et al."Jujube metabolome selection determined the edible properties acquired during domestication".PLANT JOURNAL 109.5(2022):1116-1133. |
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| 1705385893_4ddef9082（2707KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
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