Knowledge Management System Of Institute Of Botany,CAS
Natural products for infectious microbes and diseases: an overview of sources, compounds, and chemical diversities | |
Luo, Lu; Yang, Jun; Wang, Cheng1; Wu, Jie; Li, Yafang2; Zhang, Xu3; Li, Hui4; Zhang, Hui5; Zhou, Yumei6; Lu, Aiping7; Chen, Shilin | |
2022 | |
发表期刊 | SCIENCE CHINA-LIFE SCIENCES |
ISSN | 1674-7305 |
卷号 | 65期号:6页码:1123-1145 |
摘要 | As coronavirus disease 2019 (COVID-19) threatens human health globally, infectious disorders have become one of the most challenging problem for the medical community. Natural products (NP) have been a prolific source of antimicrobial agents with widely divergent structures and a range vast biological activities. A dataset comprising 618 articles, including 646 NP-based compounds from 672 species of natural sources with biological activities against 21 infectious pathogens from five categories, was assembled through manual selection of published articles. These data were used to identify 268 NP-based compounds classified into ten groups, which were used for network pharmacology analysis to capture the most promising lead-compounds such as agelasine D, dicumarol, dihydroartemisinin and pyridomycin. The distribution of maximum Tanimoto scores indicated that compounds which inhibited parasites exhibited low diversity, whereas the chemistries inhibiting bacteria, fungi, and viruses showed more structural diversity. A total of 331 species of medicinal plants with compounds exhibiting antimicrobial activities were selected to classify the family sources. The family Asteraceae possesses various compounds against C. neoformans, the family Anacardiaceae has compounds against Salmonella typhi, the family Cucurbitacea against the human immunodeficiency virus (HIV), and the family Ancistrocladaceae against Plasmodium. This review summarizes currently available data on NP-based antimicrobials against refractory infections to provide information for further discovery of drugs and synthetic strategies for anti-infectious agents. |
关键词 | natural product infectious pathogen drug discovery drug development in silico analysis |
学科领域 | Biology |
DOI | 10.1007/s11427-020-1959-5 |
收录类别 | SCI |
语种 | 英语 |
WOS关键词 | TRADITIONAL CHINESE MEDICINE ; DRUG DISCOVERY ; IN-VITRO ; CRYPTOCOCCAL MENINGITIS ; ANTIVIRAL ACTIVITY ; DATABASE ; PRION ; INHIBITION ; ANTIFUNGAL ; DESIGN |
WOS研究方向 | Science Citation Index Expanded (SCI-EXPANDED) |
WOS记录号 | WOS:000712497300002 |
出版者 | SCIENCE PRESS |
文献子类 | Review |
出版地 | BEIJING |
EISSN | 1869-1889 |
资助机构 | Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences [CI2021A04013] ; Fundamental Research Funds for the Central Public Welfare Research Institutes [L2021029] |
作者邮箱 | slchen@icmm.ac.cn |
作品OA属性 | Green Published, Bronze |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ibcas.ac.cn/handle/2S10CLM1/28476 |
专题 | 中科院北方资源植物重点实验室 |
作者单位 | 1.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China 2.Chinese Acad Med Sci & Peking Union Med Coll, Inst Basic Med Sci, Beijing 100006, Peoples R China 3.Chinese Acad Med Sci & Peking Union Med Coll, Inst Hematol & Blood Dis Hosp, Tianjin 300020, Peoples R China 4.weMED Hlth, Houston, TX 77054 USA 5.Chinese Acad Sci, Inst Bot, Beijing 100093, Peoples R China 6.Akupunktur Akademiet, DK-8230 Aabyhoej, Denmark 7.Guangzhou Univ Chinese Med, Clin Med Coll 4, Guangzhou 518033, Peoples R China 8.Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China |
推荐引用方式 GB/T 7714 | Luo, Lu,Yang, Jun,Wang, Cheng,et al. Natural products for infectious microbes and diseases: an overview of sources, compounds, and chemical diversities[J]. SCIENCE CHINA-LIFE SCIENCES,2022,65(6):1123-1145. |
APA | Luo, Lu.,Yang, Jun.,Wang, Cheng.,Wu, Jie.,Li, Yafang.,...&Chen, Shilin.(2022).Natural products for infectious microbes and diseases: an overview of sources, compounds, and chemical diversities.SCIENCE CHINA-LIFE SCIENCES,65(6),1123-1145. |
MLA | Luo, Lu,et al."Natural products for infectious microbes and diseases: an overview of sources, compounds, and chemical diversities".SCIENCE CHINA-LIFE SCIENCES 65.6(2022):1123-1145. |
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