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| Quantitative analysis of resveratrol derivatives in the seed coats of tree peonies and their hypoglycemic activities in vitro/vivo | |
| Wang, Weidong1; Liu, Zenggen1; Kong, Fan2,3; He, Lixia4; Fang, Linghao5; Shu, Qingyan2,3 | |
| 2022 | |
| Source Publication | FOOD & FUNCTION
 |
| ISSN | 2042-6496 |
| Volume | 13Issue:2Pages:846-856 |
| Abstract | Tree peonies are well-known horticultural and medicinal plants. The tree peony seeds, as emerging woody oil crops, recently have attracted great attention for their metabolites and bioactivities. In this study, the phytochemicals isolated from tree peony seed coats were systematically investigated. Seven polyphenolics were separated and prepared, mainly belonging to resveratrol derivatives. There was a great variation in the seed coat polyphenolic content among eight Paeonia species, and the contents of the resveratrol trimers and dimers were significantly higher in the seed coats of Paeonia ostii than other species. Based on the HPLC fingerprint characteristics and chemometric analysis, a clear discrimination among Paeonia plants was found, including the composition patterns and contents of the constituents. Moreover, the characteristic phytochemicals (vateriferol and trans-epsilon-viniferin) could significantly reduce the starch-mediated levels of postprandial blood glucose in diabetic/normal mice. In addition, in vitro enzyme tests showed that the two compounds could effectively and competitively inhibit alpha-glucosidase, with the IC50 values of 3.01 and 7.75 mu M, respectively, indicating that vateriferol and trans-epsilon-viniferin could be therapeutic potential agents for hyperglycemia and diabetes mellitus. |
| Subject Area | Biochemistry & Molecular Biology ; Food Science & Technology |
| DOI | 10.1039/d1fo03412j |
| Indexed By | SCI |
| Language | 英语 |
| WOS Keyword | ALPHA-GLUCOSIDASE INHIBITORS ; POSTPRANDIAL HYPERGLYCEMIA ; ROOT |
| WOS Research Area | Science Citation Index Expanded (SCI-EXPANDED) |
| WOS ID | WOS:000739563500001 |
| Publisher | ROYAL SOC CHEMISTRY |
| Subtype | Article |
| Publication Place | CAMBRIDGE |
| EISSN | 2042-650X |
| Funding Organization | Strategic Priority Research Program of CAS [XDA23080601] ; Science and Technology of Qinghai Province [2019-ZJ-7082] ; National Natural Science Foundation of China [32170394] ; CAS Light of West China Program A (2019) ; Ruilaiyin (Beijing) Biotechnology Co., Ltd. [2021C037] |
| Corresponding Author Email | lzg@nwipb.ac.cn ; shuqy@ibcas.ac.cn |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ibcas.ac.cn/handle/2S10CLM1/28674 |
| Collection | 中科院北方资源植物重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Qinghai Prov Key Lab Tibetan Med Res, Northwest Inst Plateau Biol, Xining 810001, Peoples R China 2.Chinese Acad Sci, Key Lab Tibetan Med Res, Northwest Inst Plateau Biol, Xining 810001, Peoples R China 3.Chinese Acad Sci, Key Lab Plant Resources, Inst Bot, Beijing 100093, Peoples R China 4.Chinese Acad Sci, Beijing Bot Garden, Inst Bot, Beijing 100093, Peoples R China 5.Forestry Sci Tech Extens Stn Gansu Prov, Lanzhou 730046, Peoples R China 6.Ruilaiyin Beijing Biotechnol Co Ltd, Beijing 100094, Peoples R China |
| Recommended Citation GB/T 7714 | Wang, Weidong,Liu, Zenggen,Kong, Fan,et al. Quantitative analysis of resveratrol derivatives in the seed coats of tree peonies and their hypoglycemic activities in vitro/vivo[J]. FOOD & FUNCTION,2022,13(2):846-856. |
| APA | Wang, Weidong,Liu, Zenggen,Kong, Fan,He, Lixia,Fang, Linghao,&Shu, Qingyan.(2022).Quantitative analysis of resveratrol derivatives in the seed coats of tree peonies and their hypoglycemic activities in vitro/vivo.FOOD & FUNCTION,13(2),846-856. |
| MLA | Wang, Weidong,et al."Quantitative analysis of resveratrol derivatives in the seed coats of tree peonies and their hypoglycemic activities in vitro/vivo".FOOD & FUNCTION 13.2(2022):846-856. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| _Applet_2022-05-17_f（3134KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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