Quantitative analysis of resveratrol derivatives in the seed coats of tree peonies and their hypoglycemic activities in vitro/vivo

doi:10.1039/d1fo03412j

	Quantitative analysis of resveratrol derivatives in the seed coats of tree peonies and their hypoglycemic activities in vitro/vivo
	Wang, Weidong 1; Liu, Zenggen 1; Kong, Fan 2,3; He, Lixia 4; Fang, Linghao 5; Shu, Qingyan 2,3
	2022
发表期刊	FOOD & FUNCTION
ISSN	2042-6496
卷号	13 期号:2 页码:846-856
摘要	Tree peonies are well-known horticultural and medicinal plants. The tree peony seeds, as emerging woody oil crops, recently have attracted great attention for their metabolites and bioactivities. In this study, the phytochemicals isolated from tree peony seed coats were systematically investigated. Seven polyphenolics were separated and prepared, mainly belonging to resveratrol derivatives. There was a great variation in the seed coat polyphenolic content among eight Paeonia species, and the contents of the resveratrol trimers and dimers were significantly higher in the seed coats of Paeonia ostii than other species. Based on the HPLC fingerprint characteristics and chemometric analysis, a clear discrimination among Paeonia plants was found, including the composition patterns and contents of the constituents. Moreover, the characteristic phytochemicals (vateriferol and trans-epsilon-viniferin) could significantly reduce the starch-mediated levels of postprandial blood glucose in diabetic/normal mice. In addition, in vitro enzyme tests showed that the two compounds could effectively and competitively inhibit alpha-glucosidase, with the IC50 values of 3.01 and 7.75 mu M, respectively, indicating that vateriferol and trans-epsilon-viniferin could be therapeutic potential agents for hyperglycemia and diabetes mellitus.
学科领域	Biochemistry & Molecular Biology ; Food Science & Technology
DOI	10.1039/d1fo03412j
收录类别	SCI
语种	英语
WOS关键词	ALPHA-GLUCOSIDASE INHIBITORS ; POSTPRANDIAL HYPERGLYCEMIA ; ROOT
WOS研究方向	Science Citation Index Expanded (SCI-EXPANDED)
WOS记录号	WOS:000739563500001
出版者	ROYAL SOC CHEMISTRY
文献子类	Article
出版地	CAMBRIDGE
EISSN	2042-650X
资助机构	Strategic Priority Research Program of CAS [XDA23080601] ; Science and Technology of Qinghai Province [2019-ZJ-7082] ; National Natural Science Foundation of China [32170394] ; CAS Light of West China Program A (2019) ; Ruilaiyin (Beijing) Biotechnology Co., Ltd. [2021C037]
作者邮箱	lzg@nwipb.ac.cn ; shuqy@ibcas.ac.cn
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/28674
专题	中科院北方资源植物重点实验室
作者单位	1.Chinese Acad Sci, Qinghai Prov Key Lab Tibetan Med Res, Northwest Inst Plateau Biol, Xining 810001, Peoples R China 2.Chinese Acad Sci, Key Lab Tibetan Med Res, Northwest Inst Plateau Biol, Xining 810001, Peoples R China 3.Chinese Acad Sci, Key Lab Plant Resources, Inst Bot, Beijing 100093, Peoples R China 4.Chinese Acad Sci, Beijing Bot Garden, Inst Bot, Beijing 100093, Peoples R China 5.Forestry Sci Tech Extens Stn Gansu Prov, Lanzhou 730046, Peoples R China 6.Ruilaiyin Beijing Biotechnol Co Ltd, Beijing 100094, Peoples R China
推荐引用方式 GB/T 7714	Wang, Weidong,Liu, Zenggen,Kong, Fan,et al. Quantitative analysis of resveratrol derivatives in the seed coats of tree peonies and their hypoglycemic activities in vitro/vivo[J]. FOOD & FUNCTION,2022,13(2):846-856.
APA	Wang, Weidong,Liu, Zenggen,Kong, Fan,He, Lixia,Fang, Linghao,&Shu, Qingyan.(2022).Quantitative analysis of resveratrol derivatives in the seed coats of tree peonies and their hypoglycemic activities in vitro/vivo.FOOD & FUNCTION,13(2),846-856.
MLA	Wang, Weidong,et al."Quantitative analysis of resveratrol derivatives in the seed coats of tree peonies and their hypoglycemic activities in vitro/vivo".FOOD & FUNCTION 13.2(2022):846-856.

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