Protective Function of Malus baccata (L.) Borkh Methanol Extract against UVB/Hydrogen Peroxide-Induced Skin Aging via Inhibition of MAPK and NF-κB Signaling

doi:10.3390/plants11182368

	Protective Function of Malus baccata (L.) Borkh Methanol Extract against UVB/Hydrogen Peroxide-Induced Skin Aging via Inhibition of MAPK and NF-κB Signaling
	Song, Chaoran ; Lee, Chae Young ; Lee, Hwa Pyoung ; Hossain, Mohammad Amjad ; Zhang, Zhiyun 2; Kim, Soo-Yong ; Song, Minkyung ; Kim, Jong-Hoon ; Cho, Jae Youl
	2022
发表期刊	PLANTS-BASEL
卷号	11 期号:18
摘要	Ultraviolet (UV) irradiation induces ROS production, which activates activator protein (AP)-1 and nuclear factor (NF)-kappa B signaling and downstream molecules, ultimately triggering the generation of matrix metalloproteinases (MMPs) and degradation of collagen. The aim of this study was to investigate the protective effect of methanol extract from Malus baccata (L.) Borkh (Mb-ME) against aging. DPPH and ABTS assays showed that Mb-ME had a significant antioxidant capacity. Flow cytometry results indicated that Mb-ME attenuated UVB and H2O2-stimulated apoptosis and reactive oxygen species (ROS) generation. RT-PCR analysis in HaCaT and HDF cells suggested that Mb-ME treatment blocked the expression of MMPs, COX-2, IL-1 beta, IL-6, HYALs, and p53 while promoting the levels of TGM1, FLG, HASs, Sirt1, and Col1A1. Mechanically, Mb-ME inhibited the phosphorylation of MAP kinases and NF-KB signaling. Overall, these results strongly suggest that Mb-ME can be developed as an antiaging therapy.
关键词	Malus baccata antioxidant anti-inflammatory aging
学科领域	Plant Sciences
DOI	10.3390/plants11182368
收录类别	SCI
语种	英语
WOS关键词	CANCER CELLS ; PROMOTES ; STRESS ; DEGRADATION ; METASTASIS ; KERATINOCYTES ; RESISTANCE ; APOPTOSIS ; INJURY
WOS研究方向	Science Citation Index Expanded (SCI-EXPANDED)
WOS记录号	WOS:000856715000001
出版者	MDPI
文献子类	Article
出版地	BASEL
EISSN	2223-7747
资助机构	Medical Device Technology Development Program - Ministry of Trade, Industry, and Energy (MOTIE) [20008861] ; Korea Basic Science Institute (National Research Facilities and Equipment Center) - Ministry of Education, Republic of Korea [2020R1A6C101A191]
作者邮箱	piscesmk@skku.edu ; jhkim1@jbnu.ac.kr ; jaecho@skku.edu
作品OA属性	Green Published, gold
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/28772
专题	系统与进化植物学国家重点实验室
作者单位	1.Sungkyunkwan Univ, Coll Biotechnol & Bioengn, Dept Integrat Biotechnol, Suwon 16419, South Korea 2.Chonbuk Natl Univ, Coll Vet Med, Iksan 54596, South Korea 3.Chinese Acad Sci, Inst Bot, State Key Lab Systemat & Evolutionary Bot, Beijing 100093, Peoples R China 4.Korea Res Inst Biosci & Biotechnol, Int Biol Mat Res Ctr, Daejeon 34141, Peoples R China
推荐引用方式 GB/T 7714	Song, Chaoran,Lee, Chae Young,Lee, Hwa Pyoung,et al. Protective Function of Malus baccata (L.) Borkh Methanol Extract against UVB/Hydrogen Peroxide-Induced Skin Aging via Inhibition of MAPK and NF-κB Signaling[J]. PLANTS-BASEL,2022,11(18).
APA	Song, Chaoran.,Lee, Chae Young.,Lee, Hwa Pyoung.,Hossain, Mohammad Amjad.,Zhang, Zhiyun.,...&Cho, Jae Youl.(2022).Protective Function of Malus baccata (L.) Borkh Methanol Extract against UVB/Hydrogen Peroxide-Induced Skin Aging via Inhibition of MAPK and NF-κB Signaling.PLANTS-BASEL,11(18).
MLA	Song, Chaoran,et al."Protective Function of Malus baccata (L.) Borkh Methanol Extract against UVB/Hydrogen Peroxide-Induced Skin Aging via Inhibition of MAPK and NF-κB Signaling".PLANTS-BASEL 11.18(2022).

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