Aschoff's rule on circadian rhythms orchestrated by blue light sensor CRY2 and clock component PRR9

doi:10.1038/s41467-022-33568-3

	Aschoff's rule on circadian rhythms orchestrated by blue light sensor CRY2 and clock component PRR9
	He, Yuqing 1; Yu, Yingjun 1; Wang, Xiling 1; Qin, Yumei 1; Su, Chen 1; Wang, Lei1
	2022
发表期刊	NATURE COMMUNICATIONS
卷号	13 期号:1
摘要	Circadian pace is modulated by light intensity, known as the Aschoff's rule, with largely unrevealed mechanisms. Here we report that photoreceptor CRY2 mediates blue light input to the circadian clock by directly interacting with clock core component PRR9 in blue light dependent manner. This physical interaction dually blocks the accessibility of PRR9 protein to its co-repressor TPL/TPRs and the resulting kinase PPKs. Notably, phosphorylation of PRR9 by PPKs is critical for its DNA binding and repressive activity, hence to ensure proper circadian speed. Given the labile nature of CRY2 in strong blue light, our findings provide a mechanistic explanation for Aschoff's rule in plants, i.e., blue light triggers CRY2 turnover in proportional to its intensity, which accordingly releasing PRR9 to fine tune circadian speed. Our findings not only reveal a network mediating light input into the circadian clock, but also unmask a mechanism by which the Arabidopsis circadian clock senses light intensity.
学科领域	Multidisciplinary Sciences
DOI	10.1038/s41467-022-33568-3
收录类别	SCI
语种	英语
WOS关键词	TRANSCRIPTIONAL REPRESSION ; HYPOCOTYL ELONGATION ; ARABIDOPSIS ; CRYPTOCHROMES ; GROWTH ; CCA1 ; PHYTOCHROMES ; DEGRADATION ; PROTEINS ; TIMELESS
WOS研究方向	Science Citation Index Expanded (SCI-EXPANDED)
WOS记录号	WOS:000864193100006
出版者	NATURE PORTFOLIO
文献子类	Article
出版地	BERLIN
EISSN	2041-1723
资助机构	Strategic Priority Research Program of the Chinese Academy of Sciences [XDB27030206] ; National Natural Science Foundation of China [31770287]
作者邮箱	wanglei@ibcas.ac.cn
作品OA属性	Green Published, gold
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/28862
专题	中科院植物分子生理学重点实验室
作者单位	1.Chinese Acad Sci, Inst Bot, Key Lab Plant Mol Physiol, Beijing 100093, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	He, Yuqing,Yu, Yingjun,Wang, Xiling,et al. Aschoff's rule on circadian rhythms orchestrated by blue light sensor CRY2 and clock component PRR9[J]. NATURE COMMUNICATIONS,2022,13(1).
APA	He, Yuqing,Yu, Yingjun,Wang, Xiling,Qin, Yumei,Su, Chen,&Wang, Lei.(2022).Aschoff's rule on circadian rhythms orchestrated by blue light sensor CRY2 and clock component PRR9.NATURE COMMUNICATIONS,13(1).
MLA	He, Yuqing,et al."Aschoff's rule on circadian rhythms orchestrated by blue light sensor CRY2 and clock component PRR9".NATURE COMMUNICATIONS 13.1(2022).

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