Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis

doi:10.1038/s41589-022-01196-z

IB-CAS > 中科院光生物学重点实验室

	Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis
	Wang, Boyu ; Zhang, Honghong ; Huai, Junling 1; Peng, Fangyu ; Wu, Jie ; Lin, Rongcheng1 ; Fang, Xiaofeng
	2022
Source Publication	NATURE CHEMICAL BIOLOGY
ISSN	1552-4450
Volume	18 Issue:12
Abstract	Osmotic stress imposed by drought and high salinity inhibits plant growth and crop yield. However, our current knowledge on the mechanism by which plants sense osmotic stress is still limited. Here, we identify the transcriptional regulator SEUSS (SEU) as a key player in hyperosmotic stress response in Arabidopsis. SEU rapidly coalesces into liquid-like nuclear condensates when extracellular osmolarity increases. The intrinsically disordered region 1 (IDR1) of SEU is responsible for its condensation. IDR1 undergoes conformational changes to adopt more compact states after an increase in molecular crowding both in vitro and in cells, and two predicted alpha-helical peptides are required. SEU condensation is indispensable for osmotic stress tolerance, and loss of SEU dramatically compromises the expression of stress tolerance genes. Our work uncovers a critical role of biomolecular condensates in cellular stress perception and response and expands our understanding of the osmotic stress pathway.
Subject Area	Biochemistry & Molecular Biology
DOI	10.1038/s41589-022-01196-z
Indexed By	SCI
Language	英语
WOS Keyword	REGULATORY PROTEINS ; PHASE-SEPARATION ; GENE-EXPRESSION ; DYNAMICS ; FAMILY ; LEUNIG ; VOLUME
WOS Research Area	Science Citation Index Expanded (SCI-EXPANDED)
WOS ID	WOS:000883236000001
Publisher	NATURE PORTFOLIO
Subtype	Article
Publication Place	BERLIN
EISSN	1552-4469
Funding Organization	National Natural Science Foundation of China [32161133001, 31800235, 32030009] ; Beijing Natural Science Foundation [JQ21020] ; Strategic Priority Research Program of the Chinese Academy of Sciences [XDB27030205]
Corresponding Author Email	rclin@ibcas.ac.cn ; xffang@tsinghua.edu.cn
Citation statistics	Cited Times:44[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.ibcas.ac.cn/handle/2S10CLM1/28912
Collection	中科院光生物学重点实验室
Affiliation	1.Tsinghua Univ, Ctr Plant Biol, Sch Life Sci, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Bot, Key Lab Photobiol, Beijing, Peoples R China
Recommended Citation GB/T 7714	Wang, Boyu,Zhang, Honghong,Huai, Junling,et al. Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis[J]. NATURE CHEMICAL BIOLOGY,2022,18(12).
APA	Wang, Boyu.,Zhang, Honghong.,Huai, Junling.,Peng, Fangyu.,Wu, Jie.,...&Fang, Xiaofeng.(2022).Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis.NATURE CHEMICAL BIOLOGY,18(12).
MLA	Wang, Boyu,et al."Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis".NATURE CHEMICAL BIOLOGY 18.12(2022).

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