Pharmacophylogenetic study of Scutellaria baicalensis and its substitute medicinal species based on the chloroplast genomics, metabolomics, and active ingredient

doi:10.3389/fpls.2022.951824

	Pharmacophylogenetic study of Scutellaria baicalensis and its substitute medicinal species based on the chloroplast genomics, metabolomics, and active ingredient
	Shen, Jie 1; Li, Pei ; Wang, Yue ; Yang, Kailing ; Li, Yue ; Yao, Hui ; Wang, Qiang 2; Xiao, Peigen ; He, Chunnian
	2022
发表期刊	FRONTIERS IN PLANT SCIENCE
ISSN	1664-462X
卷号	13
摘要	The genetic relationships among the species in Scutellaria genus remain unclear because of the variation in the number of species and complex trait. The usage of S. baicalensis and its four substitute medicinal species (S. amoena, S. hypericifolia, S. likiangensis, and S. viscidula) in traditional medicines make their specialized metabolism important in China, but interspecific genetic and chemical differences have rarely been reported for these species. In this study, the chloroplast genomes of four substitute species for S. baicalensis were assembled, and comparative and phylogenetic analyses were performed with these species and other Scutellaria relatives. In addition, metabolomics analyses were performed and the contents of the main active compounds were determined to reveal the interspecific chemical diversity of S. baicalensis and its four substitute species. The full lengths of their chloroplast genomes ranged from 151,574 to 151,816 bp with an average GC content of 38.34%, and a total of 113 genes were annotated. In the chloroplast genomes of S. baicalensis and its four substitutes, one hypervariable region (petA-psbL) is proposed as a potential DNA barcode. Phylogenetic analysis showed that the subdivision of the genus Scutellaria should be reconsidered. The metabolomics and content determination analyses showed that the four species exhibit a metabolism similar to that of S. baicalensis in different parts. Except for the roots of S. likiangensis, all parts of the substitute species showed high contents of baicalin. Genetic and chemical analyses of four substitute medicinal species for S. baicalensis were performed here for the first time, and their pharmacophylogenetic relationships were further explored, providing a scientific basis for the subsequent development of the medicinal value and resource utilization of Scutellaria.
关键词	Scutellaria baicalensis pharmacophylogeny substitute medicinal species chloroplast genomics metabolomics
学科领域	Plant Sciences
DOI	10.3389/fpls.2022.951824
收录类别	SCI
语种	英语
WOS关键词	DIFFERENT PARTS ; LAMIACEAE ; PHYTOCHEMISTRY ; BIOSYNTHESIS ; FLAVONOIDS ; DISCOVERY ; VISTA ; TREE
WOS研究方向	Science Citation Index Expanded (SCI-EXPANDED)
WOS记录号	WOS:000864739700001
出版者	FRONTIERS MEDIA SA
文献子类	Article
出版地	LAUSANNE
资助机构	National Administration of Traditional Chinese Medicine [ZYYCXTD-D-202005] ; CAMS Innovation Fund for Medical Sciences (CIFMS) [2021-I2M-1-071] ; Major Scientific and Technological Special Project for The Drug Innovation Major project [2018ZX09711001-008]
作者邮箱	cnhe@implad.ac.cn
作品OA属性	gold, Green Published
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/29039
专题	系统与进化植物学国家重点实验室
作者单位	1.Chinese Acad Med Sci, Peking Union Med Coll, Inst Med Plant Dev, Minist Educ,Key Lab Bioact Subst & Resources Utili, Beijing, Peoples R China 2.Weifang Med Univ, Sch Med Lab, Weifang, Peoples R China 3.Chinese Acad Sci, Inst Bot, State Key Lab Systemat & Evolutionary Bot, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Shen, Jie,Li, Pei,Wang, Yue,et al. Pharmacophylogenetic study of Scutellaria baicalensis and its substitute medicinal species based on the chloroplast genomics, metabolomics, and active ingredient[J]. FRONTIERS IN PLANT SCIENCE,2022,13.
APA	Shen, Jie.,Li, Pei.,Wang, Yue.,Yang, Kailing.,Li, Yue.,...&He, Chunnian.(2022).Pharmacophylogenetic study of Scutellaria baicalensis and its substitute medicinal species based on the chloroplast genomics, metabolomics, and active ingredient.FRONTIERS IN PLANT SCIENCE,13.
MLA	Shen, Jie,et al."Pharmacophylogenetic study of Scutellaria baicalensis and its substitute medicinal species based on the chloroplast genomics, metabolomics, and active ingredient".FRONTIERS IN PLANT SCIENCE 13(2022).

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