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| The discovery of a key prenyltransferase gene assisted by a chromosome-level Epimedium pubescens genome | |
| Shen, Guoan; Luo, Yanjiao1; Yao, Yu; Meng, Guoqing2,3; Zhang, Yixin; Wang, Yuanyue; Xu, Chaoqun; Liu, Xiang4; Zhang, Cheng5; Ding, Gang; Pang, Yongzhen1; Zhang, Hui2; Guo, Baolin | |
| 2022 | |
| 发表期刊 | FRONTIERS IN PLANT SCIENCE
 |
| ISSN | 1664-462X |
| 卷号 | 13 |
| 摘要 | Epimedium pubescens is a species of the family Berberidaceae in the basal eudicot lineage, and a main plant source for the traditional Chinese medicine Herba Epimedii. The current study achieved a chromosome-level genome assembly of E. pubescens with the genome size of 3.34 Gb, and the genome guided discovery of a key prenyltransferase (PT) in E. pubescens. Our comparative genomic analyses confirmed the absence of Whole Genome Triplication (WGT-gamma) event shared in core eudicots and further revealed the occurrence of an ancient Whole Genome Duplication (WGD) event approximately between 66 and 81 Million Years Ago (MYA). In addition, whole genome search approach was successfully applied to identify 19 potential flavonoid PT genes and an important flavonoid PT (EpPT8) was proven to be an enzyme for the biosynthesis of medicinal compounds, icaritin and its derivatives in E. pubescens. Therefore, our results not only provide a good reference genome to conduct further molecular biological studies in Epimedium genus, but also give important clues for synthetic biology and industrial production of related prenylated flavonoids in future. |
| 关键词 | Epimedium pubescens genome assembly prenyltransferase prenylated flavonoids whole genome duplication |
| 学科领域 | Plant Sciences |
| DOI | 10.3389/fpls.2022.1034943 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS关键词 | FLAVONOIDS ; BERBERIDACEAE ; CONTRIBUTES ; DIVERGENCE ; INSIGHTS ; ICARITIN ; SIZE |
| WOS研究方向 | Science Citation Index Expanded (SCI-EXPANDED) |
| WOS记录号 | WOS:000890407300001 |
| 出版者 | FRONTIERS MEDIA SA |
| 文献子类 | Article |
| 出版地 | LAUSANNE |
| 资助机构 | CAMS Innovation Fund for Medical Sciences (CIFMS) ; National Natural Science Foundation of China ; Chongqing Science and Technology Commission ; [2021-I2M-1-031] ; [2017-I2M-3-013] ; [31570306] ; [U20A2004] ; [81473302] ; [cstc2018jcyjAX0316] ; [cc-cstc-CA-19-2] ; [cstc2019jcyj-msxmx0464] ; [cstc2019jxjl-jbky10007] ; [cstc2020jxjl10004] |
| 作者邮箱 | pangyongzhen@caas.cn ; zhhui12@ibcas.ac.cn ; blguo@implad.ac.cn |
| 作品OA属性 | gold, Green Published |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ibcas.ac.cn/handle/2S10CLM1/29040 |
| 专题 | 中科院植物分子生理学重点实验室 |
| 作者单位 | 1.Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Key Lab Bioact Subst & Resources Utilizat Chinese, Minist Educ, Beijing, Peoples R China 2.Chinese Acad Agr Sci, Inst Anim Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Bot, Key Lab Plant Mol Physiol, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China 5.Chongqing Acad Chinese Mat Med, Chongqing Key Lab Tradit Chinese Med Resource, Chongqing, Peoples R China 6.Beijing Normal Univ, Coll Life Sci, Key Lab Biodivers Sci & Ecol Engn, Minist Educ, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shen, Guoan,Luo, Yanjiao,Yao, Yu,et al. The discovery of a key prenyltransferase gene assisted by a chromosome-level Epimedium pubescens genome[J]. FRONTIERS IN PLANT SCIENCE,2022,13. |
| APA | Shen, Guoan.,Luo, Yanjiao.,Yao, Yu.,Meng, Guoqing.,Zhang, Yixin.,...&Guo, Baolin.(2022).The discovery of a key prenyltransferase gene assisted by a chromosome-level Epimedium pubescens genome.FRONTIERS IN PLANT SCIENCE,13. |
| MLA | Shen, Guoan,et al."The discovery of a key prenyltransferase gene assisted by a chromosome-level Epimedium pubescens genome".FRONTIERS IN PLANT SCIENCE 13(2022). |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| 1704954528_1b775a973（10718KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
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