α-Linolenic acid induces apoptosis, inhibits the invasion and metastasis, and arrests cell cycle in human breast cancer cells by inhibiting fatty acid synthase

doi:10.1016/j.jff.2022.105041

	α-Linolenic acid induces apoptosis, inhibits the invasion and metastasis, and arrests cell cycle in human breast cancer cells by inhibiting fatty acid synthase
	Huang, Wenyuan ; Guo, Xing ; Wang, Chunyan ; Alzhan, Amantay ; Liu, Zhengan1,2 ; Ma, Xiaofeng ; Shu, Qingyan 1,2
	2022
发表期刊	JOURNAL OF FUNCTIONAL FOODS
ISSN	1756-4646
卷号	92
摘要	Fatty acid synthase (FASN) is an enzyme that synthesizes endogenous fatty acids. FASN overexpressed in various cancers, which indicates the involvement of FASN in cancer progression. alpha-Linolenic acid (ALA) is an omega-3 fatty acid with many biological activities, including anti-cancer effects. The aim of the present study was to investigate the inhibitory effect of ALA on fatty acid synthesis pathway and breast cancer cells apoptosis. We found FASN expression decreased significantly in ALA treated breast cancer cells. Compared with palmitic acid (PA), ALA reduced cell viability in a dose-dependent manner. ALA showed a higher affinity with the TE domain than PA. ALA induced breast cancer cells apoptosis, which effects were similar with the knockdown of FASN. In addition, ALA inhibited the invasion and metastasis, and arrested cell cycle in breast cancer cells. We propose a hypothesis that ALA could contribute to the treatment of human breast cancer by inhibiting FASN.
关键词	Fatty acid synthase alpha-Linolenic acid Inhibitor Breast cancer cells Cell apoptosis
学科领域	Food Science & Technology ; Nutrition & Dietetics
DOI	10.1016/j.jff.2022.105041
收录类别	SCI
语种	英语
WOS关键词	ENDOPLASMIC-RETICULUM STRESS ; GROWTH ; FASN ; METABOLISM ; EXPRESSION ; AUTOPHAGY ; HER2
WOS研究方向	Science Citation Index Expanded (SCI-EXPANDED)
WOS记录号	WOS:000792001100001
出版者	ELSEVIER
文献子类	Article
出版地	AMSTERDAM
EISSN	2214-9414
资助机构	Strategic Priority Research Program of the Chinese Academy of Sciences [XDA23080601] ; Fundamental Research Funds for the Central Universities [2012315] ; Youth Innovation Promotion Association, CAS
作者邮箱	huangwenyuan16@mails.ucas.ac.cn ; guoxing19@mails.ucas.ac.cn ; wangchunyan20@mails.ucas.ac.cn ; alzhan.zh@mail.ru ; liuzhengan@ibcas.ac.cn ; maxiaofeng@ucas.ac.cn ; shuqy@ibcas.ac.cn
作品OA属性	gold
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/29063
专题	中科院北方资源植物重点实验室
作者单位	1.Univ Chinese Acad Sci, Coll Life Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Bot, Key Lab Plant Resources, Beijing 100093, Peoples R China 3.Chinese Acad Sci, Inst Bot, Beijing Bot Garden, Beijing 100093, Peoples R China
推荐引用方式 GB/T 7714	Huang, Wenyuan,Guo, Xing,Wang, Chunyan,et al. α-Linolenic acid induces apoptosis, inhibits the invasion and metastasis, and arrests cell cycle in human breast cancer cells by inhibiting fatty acid synthase[J]. JOURNAL OF FUNCTIONAL FOODS,2022,92.
APA	Huang, Wenyuan.,Guo, Xing.,Wang, Chunyan.,Alzhan, Amantay.,Liu, Zhengan.,...&Shu, Qingyan.(2022).α-Linolenic acid induces apoptosis, inhibits the invasion and metastasis, and arrests cell cycle in human breast cancer cells by inhibiting fatty acid synthase.JOURNAL OF FUNCTIONAL FOODS,92.
MLA	Huang, Wenyuan,et al."α-Linolenic acid induces apoptosis, inhibits the invasion and metastasis, and arrests cell cycle in human breast cancer cells by inhibiting fatty acid synthase".JOURNAL OF FUNCTIONAL FOODS 92(2022).

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