Reorganization of three-dimensional chromatin architecture in Medicago truncatula under phosphorus deficiency

doi:10.1093/jxb/erac517

	Reorganization of three-dimensional chromatin architecture in Medicago truncatula under phosphorus deficiency
	Wang, Tianzuo ; Wang, Jing ; Chen, Li ; Yao, Jiaying 2; Yuan, Zan ; Zhang, Dong ; Zhang, Wen-Hao
	2023
发表期刊	JOURNAL OF EXPERIMENTAL BOTANY
ISSN	0022-0957
卷号	74 期号:6 页码:2005-2015
摘要	Emerging evidence reveals that the three-dimensional (3D) chromatin architecture plays a key regulatory role in various biological processes of plants. However, information on the 3D chromatin architecture of the legume model plant Medicago truncatula and its potential roles in the regulation of response to mineral nutrient deficiency are very limited. Using high-resolution chromosome conformation capture sequencing, we identified the 3D genome structure of M. truncatula in terms of A/B compartments, topologically associated domains (TADs) and chromatin loops. The gene density, expressional level, and active histone modification were higher in A compartments than in B compartments. Moreover, we analysed the 3D chromatin architecture reorganization in response to phosphorus (P) deficiency. The intra-chromosomal cis-interaction proportion was increased by P deficiency, and a total of 748 A/B compartment switch regions were detected. In these regions, density changes in H3K4me3 and H3K27ac modifications were associated with expression of P deficiency-responsive genes involved in root system architecture and hormonal responses. Furthermore, these genes enhanced P uptake and mobilization by increasing root surface area and strengthening signal transduction under P deficiency. These findings advance our understanding of the potential roles of 3D chromatin architecture in responses of plants in general, and in particular in M. truncatula, to P deficiency. Reorganization of the 3D chromatin architecture is associated with transcriptional regulation to enhance phosphorus uptake and mobilization in Medicago truncatulaunder phosphorus deficiency.
关键词	3D chromatin architecture histone modification hormonal response Medicago truncatula phosphorus deficiency root system architecture transcriptional regulation
学科领域	Plant Sciences
DOI	10.1093/jxb/erac517
收录类别	SCI
语种	英语
WOS关键词	3D GENOME ARCHITECTURE ; HI-C ; ARABIDOPSIS ; REVEAL ; TRANSPORTERS ; CONFORMATION ; PRINCIPLES ; CAPTURE ; DOMAINS
WOS研究方向	Science Citation Index Expanded (SCI-EXPANDED)
WOS记录号	WOS:000918996900001
出版者	OXFORD UNIV PRESS
文献子类	Article
出版地	OXFORD
EISSN	1460-2431
资助机构	Science and Technology Innovation 2030-Major Project of China [2022ZD04012] ; National Natural Science Foundation of China [32070351, 31830011] ; Science and Technology Program of Inner Mongolia, China [2021GG0372]
作者邮箱	tzwang@ibcas.ac.cn
作品OA属性	hybrid, Green Published
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ibcas.ac.cn/handle/2S10CLM1/29086
专题	植被与环境变化国家重点实验室
作者单位	1.Chinese Acad Sci, Inst Bot, State Key Lab Vegetat & Environm Change, Beijing 100093, Peoples R China 2.Univ Chinese Acad Sci, Chinese Acad Sci, Beijing 100049, Peoples R China 3.Annoroad Gene Technol Beijing Co Ltd, Beijing 100180, Peoples R China
推荐引用方式 GB/T 7714	Wang, Tianzuo,Wang, Jing,Chen, Li,et al. Reorganization of three-dimensional chromatin architecture in Medicago truncatula under phosphorus deficiency[J]. JOURNAL OF EXPERIMENTAL BOTANY,2023,74(6):2005-2015.
APA	Wang, Tianzuo.,Wang, Jing.,Chen, Li.,Yao, Jiaying.,Yuan, Zan.,...&Zhang, Wen-Hao.(2023).Reorganization of three-dimensional chromatin architecture in Medicago truncatula under phosphorus deficiency.JOURNAL OF EXPERIMENTAL BOTANY,74(6),2005-2015.
MLA	Wang, Tianzuo,et al."Reorganization of three-dimensional chromatin architecture in Medicago truncatula under phosphorus deficiency".JOURNAL OF EXPERIMENTAL BOTANY 74.6(2023):2005-2015.

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